|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants显示文摘 | Svetlana V Garkina Tatiana V Vavilova Dmitry S Lebedev Evgeny N Mikhaylov | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 3 | Morphology and surface electronic structure of MBE grown InN 显示文摘 | Himmerlich M Krischok S Lebedev V | 2007 | J Cryst Growth2007，306，： | 1 |
| 4 | Pt/GaN Schottky diodes for hydrogen gas sensors显示文摘 | Ali M Cimalla V Lebedev V | 2006 | Sensors and Actuators B2006，113，： | 1 |
| 5 | Transesterification of rapeseed oil under fiow conditions catalyzed by basic solids: M - AI(La) -O (M =Sr, Ba), M-Mg-O (M=Y, La) 显示文摘 | SHERSTYUK O V IVANOVA A S LEBEDEV M Y | 2012 | Appl Catal A- Gen2012，，： | 1 |
| 6 | Segmental dynamics in stars of poly( ethylene oxide) chains grafted to fullerene 显示文摘 | LEBEDEV V T TOROL GY CSER L | 2000 | Physica B:Condensed Matter2000，，： | 1 |
| 7 | Structure and water sorption of polyurethane nanocomposites based on organic and inorganic components显示文摘 | Mamunya Ye P ShtompelV I Lebedev E V | 2004 | European Polym J2004，40，： | 1 |
| 8 | Chronic asympto-matic hyperuricemia as a marker of atherogenic risk in children 显示文摘 | Maliavskaia S I Lebedev A V Temovskaia V A | 2007 | Kardiologiia2007，47，3： | 1 |
| 9 | Characteristics and scaling of tungsten-wire array Z pinch implosion dynamics at 20 MA显示文摘 | Cuneo M E Waisman E M Lebedev S V | 2005 | Physical Review E2005，71，04： | 1 |
| 10 | The phylogeny and systematics of the endemic Ethiopian Lophuromys flavopunctatus species complex based upon random amplified polymorphic DNA (RAPD) analysis显示文摘 | Lavrenchenko L A Potapov S G Lebedev V S | 2001 | Bioch Syst Ecol2001，29，11： | 1 |
| 11 | Cold Crucible Inductive Melting Technology Application to Vitrification and Ceramization of High Level and Actinide Wastes显示文摘 | Stefanovsky S V Lebedev V V Ptashkin A G | 2010 | Advances in Science and Technology2010，73，： | 1 |
| 12 | Broadband neutron spin-flippers on magnetized foils显示文摘 | LEBEDEV V T TRK G | 2002 | Nuclear Instruments and Methods in Physics Research A2002，195，： | 1 |
| 13 | Fihn-Cooling Efficiency in a Laval Nozzle Under Conditions of High Freestream Turbulence 显示文摘 | Lebedev V P Lemanov V V Terekhov V I | 2006 | Journal of Heat Transfer2006，28，： | 1 |
| 14 | Plasma formation and implosion structure in wire array Z pinches显示文摘 | Chittenden J P LebedevS V Bell A R | 1999 | PhysRev Lett1999，83，： | 1 |
| 15 | One-, two-, and three-dimensional modeling of the different phases of wire array Z-pinch evolution显示文摘 | Chittenden J P Lebedev S V Bland S N el al | 2001 | Phys Plasmas2001，8，： | 1 |
| 16 | Crossed products by endomorphisms and reduction of relations in relative Cuntz-Pimsner algebras显示文摘 | Kwasniewski B K Lebedev A V | 2013 | J Func Anal2013，264，： | 1 |
| 17 | Equilibrium flow structures and scaling of implosion trajectories in wire array Z pinches 显示文摘 | Chittenden J P Lebedev S V Oliver B V | 2004 | PhysPlasmas2004，11，： | 1 |
| 18 | Epitaxial growth of AlN and GaN on Si(111)by plasmaassisted molecular beam epitaxy显示文摘 | Schenk H P D Kipshidze G D Lebedev V B | 1999 | J Cryst Grow1999，，： | 1 |
| 19 | OXYS rats as a model of senile cataract显示文摘 | KOLOSOVA N G LEBEDEV P A AIDAGULOVA S V | 2003 | Bull Exp Biol Med2003，136，41： | 1 |
| 20 | Possible absorption of solar energy by the Earth's crystalline matter显示文摘 | Lebedev V I | 1954 | Izv AN SSSR Ser Geol1954，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员