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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Irritable bowel syndrome symptom severity improves equally with probiotic and placebo显示文摘AIM To determine the effects of Lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited according to Rome Ⅲ criteria received 109 or 1010 colony-forming units of NCFM or placebo daily for 12 wk. IBS Symptom Severity Score(IBS-SSS), which constituted the primary outcome, and secondary outcomes, including individual IBS symptoms, IBS-related QoL questionnaire, anxiety and depression, defecation frequency, and stool consistency, were assessed at baseline at the end of the 8-wk runin period, after 4 and 12 wk of intervention, and after a 4-wk washout.RESULTS A total of 340 of 391 randomized volunteers completed the trial. IBS-SSS improved over 12 wk of treatment in all treatment groups, decreasing by a mean ± SD of 44.0 ± 80.2, 50.8 ± 82.4, and 48.3 ± 72.2 in the placebo, active low-dose, and active high-dose groups, respectively. Similarly, secondary outcomes did not differ between treatment groups. However, in a post hoc analysis of volunteers with moderate to severe abdominal pain at baseline(VAS > 35/100), the treatment significantly reduced the sensation of abdominal pain. Pain scores fell by 20.8 ± 22.8, 29.4 ± 17.9, and 31.2 ± 21.9 in the placebo, active low-dose, and active high-dose groups, respectively(P value for placebo vs combined active doses = 0.0460).CONCLUSION NCFM alleviates moderate to severe abdominal pain, consistent with earlier observations of this strain mitigating visceral pain through increased analgesic receptor expression. | Anna Lyra Markku Hillila Teppo Huttunen Sofia Mannikko Mikko Taalikka Julia Tennila Anneli Tarpila Sampo Lahtinen Arthur C Ouwehand Lea Veijola | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 3 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 4 | Cytokines and the regulation of apoptosis in reproductive tissues: a review显示文摘 | Lea RG Riley SC Antipatis C | 1999 | Am J Reprod Immunol1999，42，： | 2 |
| 5 | Mechanism and importance of post-translational regulation of nitrate reductase 显示文摘 | Lillo C Meyer C Lea U S Provan F Oltedal S | 2004 | J Exp Bot2004，55，401： | 1 |
| 6 | The JAK2 V617F mutation is rare in RARS but common in RARS - T 显示文摘 | CEESAY M M LEA N C INGRAM W | 2006 | Leukemia2006，20，11： | 1 |
| 7 | Cytokines and the regulation of apoptosis in reproductive tissues: a review显示文摘 | Riley S C Antipatis C | 1999 | Am J Reprod Immunol1999，42，2： | 1 |
| 8 | Barium and strontium uptake into larval pro-toconchs and statoliths of the marine neogastropod Kelletia Kelletii显示文摘 | Danielle C Zacherl Georges Paradis David W Lea | 2003 | Geochimica et Cosmo-chimica Acta2003，67，21： | 1 |
| 9 | Reality check: augmentedreality for school libraries显示文摘 | Green M Lea J H Mcnair C L | 2014 | Teacher Librarian2014，1，5： | 1 |
| 10 | Routing and Time-Slot Assignment in Photonic Circuit Switching Networks显示文摘 | Yu W W Wong A K Lea C T | 2002 | IEEE GIOBECOM2002，，： | 1 |
| 11 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 12 | Inhibition of growth and in- duction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides 显示文摘 | Lea MA Ibeh C Deutsch JK | 2010 | Anticancer Res2010，30，9： | 1 |
| 13 | Mortalities of pond-cultured juvenile shrimp, Penaeus monodon, associated with dominance of luminescent Vibrios in the rearing environment显示文摘 | Lavilla-Pitogo C R Lea?o E M Paner M G | 1998 | Aquaculture1998，164，14： | 1 |
| 14 | Differential expression of four Arabidopsis PAL genes; PAL1 and PAL2 have functional specialization in abiotic environmental-triggered flavonoid synthesis 显示文摘 | OLSEN K M LEA U S LILLO C | 2008 | Journal of Plant Physiology2008，，165： | 1 |
| 15 | Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells 显示文摘 | Lea MA Ibeh C Han L | 2010 | Anticancer Res2010，30，2： | 1 |
| 16 | Effect of stress and dexamethasone treatment on circadian rhythms of melatonin and corticosterone in ring dove (Streptopelia risoria)显示文摘 | Barriga C Marchena J M Lea R W | 2002 | Mol Cell Biochem2002，232，12： | 1 |
| 17 | Commitment point during GOG1 that controls entry into the cell cycle 显示文摘 | LEA N C ORR S J STOEBER K | 2003 | Mol Cell Biol2003，23，7： | 1 |
| 18 | The phenolic cinnamates of white grapes and wine显示文摘 | Timberlake C F Lea A G H | 1978 | J Sci Food Agric1978，29，： | 1 |
| 19 | Absolute frequency measurements of 633nm iodine-stableized helium-neon lasers 显示文摘 | Lea S N Rowley W R C Margolis H S | 2005 | Metrologia2005，40，2： | 1 |
| 20 | Quantitative solderability measurement of electronic components, part 3:surfaces of standard solderability 显示文摘 | LEA C DENCH W A | 1990 | Soldering Surf Mt Technol1990，5，： | 1 |
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