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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 3 | Synthesis of cation exchange resin-supported iron and magnesium oxides/hydroxides composite for nitrate removal in water显示文摘In this study,we reported on the concept and practical use of cation exchange resin(CER)for removing anions in water via pretreating the CER with metal salts.The cation exchange resinsupported iron and magnesium oxides/hydroxides composite(FeMg/CER)was synthesized and introduced as a new and potential adsorbent for selective removal of nitrate ion in the water environment.Characteristics of FeMg/CER were determined by techniques such as Fouriertransform infrared spectroscopy,scanning electron microscopy,and Xray diffraction.The results showed that FeMg/CER material had a high nitrate adsorption capacity of 200 mg NO_(3)^()·g^(1)with a fast equilibrium adsorption time of 30 min at pH 5.In addition,it had good durability of at least 10 times of regeneration,which could be applied to practical water and wastewater treatment. | Trung Thanh Nguyen Vu Anh Khoa Tran Le Ba Tran Phuoc Toan Phan Minh Tan Nguyen Long Giang Bach Surapol Padungthon Cong Khiem Ta Nhat Huy Nguyen | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 4 | Clinical evaluation of patients with temporomandibular joint implants显示文摘 | Ta LE | 2002 | J Oral Maxillofac Surg2002，60，12： | 1 |
| 5 | Characterization of vas- cular development in the mouse retina显示文摘 | Connolly SE Hores TA Smith LE | 1988 | Microvase Res1988，36，3： | 1 |
| 6 | Association of diabetes with mammographic breast density and breast caneer in the Minnesota breast cancer family study显示文摘 | Sellers TA Jensen LE Vierkant RA | 2007 | Cancer Causes Contr2007，18，5： | 1 |
| 7 | Cytokine milieu modulates re- lease of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA 显示文摘 | Kinoshita H Takai T Le TA | 2009 | J Allergy Clin Immu- nol2009，123，17： | 1 |
| 8 | Fatal blunt aortic injuries:a review of 242 autopsy cases显示文摘 | Burkhart HM Gomez GA Jacobson LE Pless JE Broadie TA | | 0，，： | 1 |
| 9 | Age-specific Trends in mammographic Density: the Minnesota Breast Cancer Family Study显示文摘 | Kelemen LE Pankratz VS Sellers TA | 2008 | Am J Epidemiol2008，167，9： | 1 |
| 10 | Mouse model of SCN5A-linked hereditary Lenegre's disease: age-related conduction slowing and myocardial fibrosis显示文摘 | Royer A van Veen TA Le Bouter S | 2005 | Circulation2005，111，： | 1 |
| 11 | Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding 显示文摘 | Ta LE Espeset L Podratz J | 2006 | Neurotoxicology2006，27，6： | 1 |
| 12 | Clonal expansion and microevolution of quinolone-resistant Salmonella enterica serotype typhi in Vietnam from 1996 to 2004 显示文摘 | Le TA Fabre L Roumagnac P | 2007 | J Clin Microbiol2007，45，11： | 1 |
| 13 | HER-2overexpression is an independent marker of poor prognosis of advanced primary ovarian carci-noma:a multicenter study of the GINECO group显示文摘 | Camilleri-Broet S Hardy-Bessard AC Le TA | 2004 | Ann Oncol2004，15，： | 1 |
| 14 | Characterization of cell membrane response to ultrasound activated microbubbles显示文摘 | Tran TA Le Guennec JY Bougnoux P | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，1： | 1 |
| 15 | Effect of ultrasound-activated microbubbles on the cell electrophysiological properties显示文摘 | Tran TA Roger S Le Guennec JY | | 0，，01： | 1 |
| 16 | Axonal injury in the optic nerve: a model simulating diffuse axonal injury in the brain 显示文摘 | Gennarelli TA Thibauh LE Tipperman R | 1989 | J Neurosurg1989，71，2： | 1 |
| 17 | Crystal structure of Pseudomonas aeruginosa SPM-1 provides insightsinto variable zinc affinity of metallo-β-1actamases显示文摘 | Murphy TA Catto LE Halford SE | 2006 | J Molecular Biology Biol2006，357，： | 1 |
| 18 | Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03) 显示文摘 | Le Clerc S Limou S Coulonges C Carpentier W Dina C Taing L Delaneau O Labib T Sladek R ANRS Genomic Group Deveau C Guillemain H Ratsimandresy R Montes M Spadoni JL Therwath A Schichter F Matsuda F Gut I Leli6vre JD L6vy Y Froguel P Delfraissy JF Hercberg S Zagury JF | 2009 | Infect Dis2009，200，8： | 1 |
| 19 | Diffuse axonal injury and traumatic coma in the primate 显示文摘 | Gennarelli TA Thibauh LE Adams JH | 1982 | Ann Neurol1982，12，6： | 1 |
| 20 | Electroconvulsive therapy for depression after temporal lobectomy for epilepsy显示文摘 | Krahn LE Rummans TA Peterson GC | 1993 | Convuls Ther1993，9，： | 1 |
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