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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Why total knees fail-A modern perspective review显示文摘Historically, the most common mechanism of total kneearthroplasty(TKA) failures included aseptic loosening, instability and malalignment. As polyethylene production improved, modes of failure from polyethylene wear and subsequent osteolysis became less prevalent. Newer longitudinal studies report that infection has become the primary acute cause of failure with loosening and instability remaining as the overall greatest reasons for revision. Clinical database and worldwide national registries confirm these reports. With an increasing amount of TKA operations performed in the United States, and with focus on value-based healthcare, it is imperative to understand why total knees fail. | Zachary C Lum Alvin K Shieh Lawrence D Dorr | 2018 | World Journal of Orthopedics2018，9，4： | 9 |
| 3 | ERCC2诱导表达在人脑胶质瘤细胞对BCNU耐药中的作用显示文摘目的 探讨BCNU诱导ERCC2表达在胶质瘤细胞耐药中的作用。方法 选用ERCC2基础表达在蛋白水平相同 ,而mRNA水平不同的 2株人脑胶质瘤细胞T98 G和SK MG 4(在mRNA水平 ,T98 G比SK MG 4高 2 5倍 ) ,在体外培养时用BCNU处理 ,随后采用WesternBlot测定肿瘤细胞的ERCC2蛋白水平变化。结果 对BCNU耐药的T98 G在BCNU处理后 6h ,ERCC2蛋白水平上升 6倍 ,随后逐渐下降 ,48h回复到基础水平。而对BCNU敏感的SK MG 4,BCNU处理后ERCC2蛋白水平没有增加。结论 本研究提示 ,mRNA基础水平与胶质瘤耐药密切相关 ,在mRNA基础水平较高的肿瘤细胞 ,BCNU能诱导ERCC2蛋白表达 ,并直接与肿瘤耐药相关。 | 陈忠平 Grard Mohr Lawrence C Panasci | 2003 | 中华神经外科杂志2003，19，1： | 5 |
| 4 | Microstructure and mechanical properties of Ti-6Al-4V-5% hydroxyapatite composite fabricated using electron beam powder bed fusion显示文摘A novel, Ti-6 Al-4 V(Ti64)/Hydroxyapatite(HA at 5% by weight concentration) metal/ceramic composite has been fabricated using electron beam powder bed fusion(EPBF) additive manufacturing(AM): specifically, the commercial electron beam melting(EBM?) process. In addition to solid Ti64 and Ti64/5% HA samples, four different unit cell(model) open-cellular mesh structures for the Ti64/5% HA composite were fabricated having densities ranging from 0.68 to 1.12 g/cm^3, and corresponding Young's moduli ranging from 2.9 to 8.0 GPa, and compressive strengths ranging from ~3 to 11 MPa. The solid Ti64/5%HA composite exhibited an optimal tensile strength of 123 MPa, and elongation of 5.5% in contrast to a maximum compressive strength of 875 MPa. Both the solid composite and mesh samples deformed primarily by brittle deformation, with the mesh samples exhibiting erratic, brittle crushing. Solid, EPBF-fabricated Ti64 samples had a Vickers microindentation hardness of 4.1 GPa while the Ti64/5%HA solid composite exhibited a Vickers microindentation hardness of 6.8 GPa. The lowest density Ti64/5%HA composite mesh strut sections had a Vickers microindentation hardness of 7.1 GPa. Optical metallography(OM) and scanning electron microscopy(SEM) analysis showed the HA dispersoids to be highly segregated along domain or grain boundaries, but homogeneously distributed along alpha(hcp) platelet boundaries within these domains in the Ti64 matrix for both the solid and mesh composites. The alpha platelet width varied from ~5 μm in the EPBF-fabricated Ti64 to ~1.1 m for the Ti64/5%HA mesh strut. The precursor HA powder diameter averaged 5 μm, in contrast to the dispersed HA particle diameters in the Ti64/5%HA composite which averaged 0.5 m. This work highlights the use of EPBF AM as a novel process for fabrication of a true composite structure, consisting of a Ti64 matrix and interspersed and exposed HA domains, which to the authors' knowledge has not been reported before. The results also illustrate the prospects not only for fabricating specialized, novel composite bone replacement scaffolds and implants, through the combination of Ti64 and HA, but also prospects for producing a variety of related metal/ceramic composites using EPBF AM. | César A.Terrazas Lawrence E.Murr Diego Bermudez Edel Arrieta David A.Roberson Ryan B.Wicker | 2019 | Journal of Materials Science & Technology2019，35，2： | 4 |
| 5 | Lithologic mapping in the Mountain Pass, California area using Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data显示文摘 | Lawrence C Rowan John C Mars | 2002 | Remote Sensing of Environment2002，，3： | 2 |
| 6 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 7 | 基于颜色特征的含黄曲霉毒素玉米颗粒的检出方法显示文摘为快速准确识别出感染黄曲霉毒素的玉米颗粒,基于黄曲霉毒素在365 nm紫外光照射下可发出黄绿色荧光(bright greenish-yellow fluorescence,BGYF)的特性,提出了一种以颜色为特征量的感染毒素颗粒的检出方法。首先针对同一组玉米颗粒样本分别获取其在紫外光和可见光下的2幅图像,对可见光图像进行二值化、颗粒区域填充等预处理操作,得到玉米颗粒的轮廓与位置信息;然后将进行彩色增强后的紫外光图像与预处理后的可见光图像掩膜;最后在掩膜图像中通过RGB模型中G通道下的阈值作为分割参数识别玉米颗粒上的感染区域。结果表明,所提出的识别方法对能够发出荧光的含黄曲霉菌玉米颗粒识别准确率达到84%以上,对含有黄曲霉毒素的正确检出率可达77.8%以上,能够达到区分检测的要求。 | 褚璇 王伟 Lawrence Kurt C Ni Xinzhi Heitschmidt Gerald W 张楠楠 彭彦昆 | 2015 | 中国粮油学报2015，30，4： | 2 |
| 8 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 9 | Morphology and orientation evolution of Cu_(6)Sn_(5)grains on(001)Cu and(011)Cu single crystal substrates under temperature gradient显示文摘The morphology and orientation evolution of Cu_(6)Sn_(5)grains formed on(001)Cu and(011)Cu single crystal substrates under temperature gradient(TG)were investigated.The initial orientated prism-type Cu_(6)Sn_(5)grains transformed to non-orientated scallop-type after isothermal reflow.However,the Cu_(6)Sn_(5)grains with strong texture were revealed on cold end single crystal Cu substrates by imposing TG.The Cu_(6)Sn_(5)grains on(001)Cu grew along their c-axis parallel to the substrate and finally merged into one grain to form a fully IMC joint,while those on(011)Cu presented a strong texture and merged into a few dominant Cu_(6)Sn_(5)grains showing about 30°angle with the substrate.The merging between neighboring Cu_(6)Sn_(5)grain pair was attributed to the rapid grain growth and grain boundary migration.Accordingly,a model was put forward to describe the merging process.The different morphology and orientation evolutions of the Cu_(6)Sn_(5)grains on single crystal and polycrystal Cu substrates were revealed based on crystallographic relationship and Cu flux.The method for controlling the morphology and orientation of Cu_(6)Sn_(5)grains is really benefitial to solve the reliability problems caused by anisotropy in 3 D packaging. | Yuanyuan Qiao Xiaoying Liu Ning Zhao Lawrence C M Wu Chunying Liu Haitao Ma | 2021 | Journal of Materials Science & Technology2021，，36： | 2 |
| 10 | Texture development during cheese ripening显示文摘 | LAWRENCE R C | 1987 | Dairy Sci1987，74，： | 2 |
| 11 | The behaviour and ecology of the zebrafish, Danio rerio 显示文摘 | Spence R Gerlach G Lawrence C | 2008 | Biol Rev Camb Philos Soc2008，83，： | 1 |
| 12 | Odour - taste interactions: A way to enhance saltiness in low-sah content solutions 显示文摘 | Lawrence G Salles C Septier C | 2009 | Food Quality and Preference2009，20，： | 1 |
| 13 | Immunolocalization of type III collagen in human articular cartilage prepared by high- pressure eryofixation, freeze-substitution, and low-temperature embedding显示文摘 | Young R D Lawrence P A Duanee V C | 1995 | J Histochem Cytochem1995，43，4： | 1 |
| 14 | Global elemental maps of the Moon: The lunar prospector gamma ray spectromet er显示文摘 | Lawrence D J Feldman W C Barraclough B L | 1998 | Science1998，281，： | 1 |
| 15 | Subaperture testing of aspheres with annular zones显示文摘 | Liu Y M Lawrence G N Koliopoulos C L | 1988 | Appl Opt1988，27，21： | 1 |
| 16 | Fluid flow along a channel with an asymmetric oscillating constriction显示文摘 | Stephanoff K D Pedley T J Lawrence C J Secomb T W | 1983 | Nature1983，305，20： | 1 |
| 17 | Context and Page Analysis for Improved Web Search显示文摘 | Lawrence S Giles C L | 1998 | IEEE Internet Computing1998，2，4： | 1 |
| 18 | The association of glutenin subunits with gliadin composition and grain quality in wheat显示文摘 | WRIGLEY C W LAWRENCE G J SHEPHERD K W | 1982 | Aust J Plant Physiol1982，，9： | 1 |
| 19 | Effects of a single pre-oper- ative dexmedetomidine dose on isoflurane requirements and peri-operative haemodynamic stability 显示文摘 | Lawrence C J Lange SD | 1997 | Anaes- thesia1997，52，8： | 1 |
| 20 | Cyclic stretch in- duced oxidative stress increases pulmonary alveolar epithelial perme- ability显示文摘 | Davidovich N Di Paolo B C Lawrence G G | 2013 | Am J Respir Cell Mol Biol2013，49，1： | 1 |
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