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| 1 | 圆锥角膜的诊断和治疗显示文摘圆锥角膜以角膜扩张为特征,能致角膜前凸和不规则近视散光。较晚期病例出现角膜水肿,大多在数周至数月内愈合,伴有瘢痕形成。其它体征有基质神经纤维显见、Vogt条纹和基底瘢痕。轻症可戴眼镜矫正视力。软性角膜接触镜很少或没有治疗价值。硬性角膜接触镜的主要受力面应置于较坚韧的周边角膜上,以尽量减少与圆锥顶端的接触,防止瘢痕形成,减少泪液积聚和增加圆锥周围的泪液交换。若不能耐受角膜接触镜或戴镜不能显著提高视力,应行角膜移植。穿透性角膜移植可降低角膜畸变,去除中央瘢痕,增加对比视敏度。角膜热成形术光学效果不好。板层角膜移植操作困难。角膜表面镜片术的作用有待于进一步研究。 | Michael Lawless 高翔 | 1990 | 国外医学(眼科学分册)1990，14，4： | 5 |
| 2 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 3 | Control of volatile organic compounds by an AC energized ferroelectric pellet reactor and a pulsed corona reactor显示文摘 | Yamamoto K Ramanathan P A Lawless | 1992 | IEEE Trans Ind Applicat1992，28，2： | 2 |
| 4 | Risk factors for repeated cerebrospinal shunt failures in pediatric patients with hydrocephalus显示文摘 | Tuli S Drake J Lawless J | 2000 | J Neurosurg2000，92，1： | 1 |
| 5 | Using concept sorting and concept mapping in business and public administration,and in education: an overview显示文摘 | Lawless C Smee P O'Shea T | 1998 | Educ Res1998，40，2： | 1 |
| 6 | Flavor description of white wine by‘expert’and nonexpert wine consumers显示文摘 | Lawless H T | 1984 | Journal of Food Science1984，49，1： | 1 |
| 7 | Corona discharge processes显示文摘 | Chang J Lawless P A Yamamoto T | 1991 | IEEE Transactions on Plasma Science1991，19，6： | 1 |
| 8 | Combined Effects of Carbon Dioxide Addition and Barrier Films on Microbial and Sensory Changes in Pasteurized Milk显示文摘 | HOTCHKISS J H CHEN J H LAWLESS H T | 1999 | J Dairy Sci1999，82，： | 1 |
| 9 | Control of volatile organic compounds by an ac energized ferroelectric pellet reactor and a pulsed corona reactor显示文摘 | YamamotoT Ramanathan K Lawless P A | 1992 | IEEE Transactions Industry Application1992，28，5： | 1 |
| 10 | Dissociation of tau toxicity and phosphorylation:role of GSK-3beta MARK and Cdk5 in a Drosophila model显示文摘 | Chatterjee S Sang TK Lawless GM | | 0，，： | 1 |
| 11 | Steroidal guani- dinium receptors for the enantioselective recognition of N-acyl c-amino acids 显示文摘 | Anthony P Davis Laurence J Lawless | 1999 | Chemical Communica- tions1999，，1： | 1 |
| 12 | Conjugated linoleic acid in bovine milk fat:a food -based approach to cancer chemoprevention 显示文摘 | M OShea F Lawless C Stanton R Devery | 1998 | Trends in Food Science & Technology1998，，9： | 1 |
| 13 | Toll-like receptor signalling in liver disease: ER stress the missing link? 显示文摘 | Lawless MW Greene CM | 2012 | Cytokine2012，59，2： | 1 |
| 14 | Marginal Distance: Does Export Experience Reduce Firm Trade Costs?显示文摘 | Martina Lawless | 2013 | Open Economies Review2013，，5： | 1 |
| 15 | Pervaporation with chitosan membranes: separation of dimethyl carbonate/methanol/water mixtures 显示文摘 | Won Wooyoung Feng Xianshe Lawless Darren | 2002 | J Membr Sci2002，209，： | 1 |
| 16 | A wheat canopy model linking leaf area and phenology 显示文摘 | Lawless C Semenov M A Jamieson P D | 2005 | European Journal of Agronomy2005，22，： | 1 |
| 17 | Comprehensive kinetic model for electron-beam-excited(Xe Cs)+ ionic excimens显示文摘 | Lo D | 1995 | Appl Phys1995，60，103： | 1 |
| 18 | Separation of dimethyl carbonate/methanol/water mixtures by pervaporation using crosslinked chitosan membranes显示文摘 | Won Wooyoung Feng Xianshe Lawless Darren | 2003 | Sep Pur Technol2003，31，： | 1 |
| 19 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Timothy V Roberts Michael Lawless Colin CK Chan Mark Jacobs David Ng Shveta J Bali Chris Hodge Gerard Sutton | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 20 | Effect of FM-receiver gain on speech-recognition performance of adults with cochlear implants显示文摘 | Schafer EC Wolfe J Lawless T | 2009 | Int J Audiol2009，48，4： | 1 |
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