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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Establishment,characterization,karyotyping,and comparative genomic hybridization analysis of HKESC-2 and HKESC-3:two newly established human esophageal squamous cell carcinoma cell lines显示文摘 | Hu YC Lam KY Law SY | | 0，，02： | 1 |
| 3 | Multiple primary cancers in esophageal squamous cell carcinoma:incidence and implications 显示文摘 | Poon RT Law SY Chu KM | 1998 | Ann Thorac Surg1998，65，6： | 1 |
| 4 | Multiple primary cancer in esophapeal sequamous cell carcinoma:incidence and implications显示文摘 | Poon RT Law Sy Chu KM | 1998 | Ann Thoracic Surg1998，65，6： | 1 |
| 5 | Establishment,characterization,karyotyping,and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines显示文摘 | Hu YC Lam KY Law SY | 2002 | Cancer Genet Cytogenet2002，135，2： | 1 |
| 6 | Esophagectomy for carcinoma of the esophagus in the elderly:results of current surgical management显示文摘 | Law SY Chu KM | 1998 | Ann Surg1998，227，3： | 1 |
| 7 | Multiple primary cancers in esophageal squamous cell carcinoma, incidence and implication显示文摘 | Poon R T Law SY Chu KM | 1998 | Ann Thorae Surg1998，65，： | 1 |
| 8 | Esophagectomy for carcinoma of the esophagus in the elderly:results of current surgical management显示文摘 | Poon RT Law SY Chu KM | 1998 | Ann Surg1998，227，3： | 1 |
| 9 | Multiple primary cancer in esophageal sequamous cell carcinoma : incidence and implications显示文摘 | Poon RT Law SY Chu KM | 1998 | Ann Thorac Surg1998，65，6： | 1 |
| 10 | Soluble E-cadherin is a valid prognostie marker in gastric carcinoma显示文摘 | Chan AO Lam SK Chu KM Lam CM Kwok E Leung SY Yuen ST Law SY Hui WM Lai KC Wong CY Hu HC Lai CL Wong J | | 0，，： | 1 |
| 11 | A comparison of outcome after resection for squamous cell carcinomas and adenocarcinomas of the esophagus and cardia 显示文摘 | LAW SY FOK M CHENG SW | 1992 | Stag Gynecol Obstet1992，175，2： | 1 |
| 12 | Small cell carcinoma of the esophagus 显示文摘 | Law SY Fok M Lain KY | 1994 | Cancer1994，73，12： | 1 |
| 13 | Randomized double- masked controlled trial comparing pain scores with and without the use of supplementary 2% lidocaine gel in LASIK 显示文摘 | Lam DS Law RW Anita SY | 2011 | Am J Ophthalmol2011，153，4： | 1 |
| 14 | Comparison of handewn andstapled esophagogastrie anastomosjs after esophageal resection forcancer显示文摘 | Law SY Fok M Chu KM | 1997 | Ann Surg1997，226，2： | 1 |
| 15 | Establishment,characterization,karyotyping,and comparative genomic hybridization analysis of HKESC-2 and HKESC-3:two newly established human esophageal squamous cell carcinoma cell lines显示文摘 | Hu YC Lam KY Law SY | 2002 | Cancer Genet Cytogenet2002，135，2： | 1 |
| 16 | Baerveldt-350 implant versus Ahmed valve for refractory glaucoma:a case-controlled comparison显示文摘 | Syed HM Law SK Nam SH | | 0，，01： | 1 |
| 17 | Baerveldt-350 implant versus Ahmed valve for refractory glaucoma:a case-controlled comparison显示文摘 | Syed HM Law SK Nam SH Li G Caprioli J Coleman A | | 0，，01： | 1 |
| 18 | Pattern of recurrence after oesophageal resection for cancer:clinical implication显示文摘 | Law SY Fok M Wong J | 1996 | Br J Surg1996，83，1： | 1 |
| 19 | Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines 显示文摘 | Hu YC Lam KY Law SY | 2002 | Cancer Genet Cytogenet2002，135，2： | 1 |
| 20 | Multiple primary cancer in esophageal seqeamous cell carcinoma: incidence and implications 显示文摘 | Poon RJ Law SY Chu KM | 1998 | Ann Thoracic surg1998，65，： | 1 |
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