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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | Smad3 knock-out mice as a useful model to study intestinal fibrogenesis显示文摘瞄准:为了在形态学和免疫评估可能的差别, CD3,转变生长因素 beta1 (TGF-beta1 ) , Smad7, alpha 光滑的肌肉肌动朊(alpha-Sma ) ,和骨胶原的组织化学的表示打 I-VII 小并且在 Smad3 空、野类型的老鼠的大肠。方法:十 0 和十只野类型的成年老鼠在年龄和机关的 4 瞬间被牺牲(食管,小、大的肠,输尿管) 为组织学被收集(苏木精和曙红,马森 thrichrome,染色的银) ,形态测定法和免疫组织化学分析。肠的织物 homogenates 的 TGF-beta1 层次被 ELISA 估计。结果:没有宏观的肠的损害在空、野类型的老鼠两个都被检测。组织学并且 morphometric 评估在肌肉层厚度揭示了重要减小小并且在空老鼠的大肠同样与野类型的老鼠相比。Immunohistochemistry 评估显示出染色在的 CD3+ T 房间, TGF-beta1 和 Smad7 的重要增加小并且 Smad3 空老鼠的大肠粘膜同样与野类型的老鼠相比。染色的 Alpha-Sma 和骨胶原 I-VII 小并且大肠没在二组老鼠之间不同。结肠的织物 homogenates 的 TGF-beta1 层次比在野类型的老鼠在空老鼠是显著地更高的。在初步的实验,导致 TNBS 的肠的纤维变性的重要减小作为与野类型的老鼠相比在空老鼠被观察。结论:Smad3 空老鼠是一个有用模型调查在肠的发炎和纤维变性表明小径的 TGF-beta/Smad 的在活体内角色。 | Giuliana Zanninelli Antonella Vetuschi Roberta Sferra Angela D'Angelo Amato Fratticci Maria Adelaide Continenza Maria Chiaramonte Eugenio Gaudio Renzo Caprilli Giovanni Latella | 2006 | World Journal of Gastroenterology2006，12，8： | 3 |
| 3 | Automatic verification of a behavioural subset of UML Statechart digrams using the SPIN model-checker显示文摘 | Latella D Majzik I Massink M | 1999 | Formal Aspects of Computing1999，11，6： | 1 |
| 4 | Predictive ability of a predis-charge hour - specific serum bilirubin for hyperbilirubinemia in full terminfants 显示文摘 | Tiberi E Latella C Parenti D | 2007 | Minerva Pediatr2007，59，3： | 1 |
| 5 | Automatic verification of a behavioural subset of UML stateehart diagrams using the SPIN modelcheeker显示文摘 | Latella D Majzik I Massink M | 1999 | Formal Aspects of Computing1999，11，6： | 1 |
| 6 | Automatic verification of a behavioral subset of UML statechart diagrams using the SPIN model-checker显示文摘 | LATELLA D MAJZIK I MASSINK M | 1999 | Formal Aspects of Computing1999，11，6： | 1 |
| 7 | Reactiva tion and risk of sequelae in langerhans cell histioeyto sis显示文摘 | POLLONO D REY G LATELLA A | 2007 | Pediatr Blood Cancer2007，48，： | 1 |
| 8 | Automatic verification of a behavioural subset of UML Statechart diagrams using the SPIN model-checker显示文摘 | Latella D Majzik I Massink M | 1999 | Formal Aspects of Computing1999，11，6： | 1 |
| 9 | Automatic Verification of a Behavioral Subset of UML Statechart Diagrams Using the SPIN Model-checker显示文摘 | LATELLA D MAJZIK I MASSINK M | 1999 | Formal Aspects of Computing1999，，11： | 1 |
| 10 | Reactivation and Risk of sequelae in Langerhans cell histiocytosis显示文摘 | Pollono D Rey G Latella A | | 0，，： | 1 |
| 11 | Importance of multi-lineage hematologic involvement and hypoalbuminemia at diagnosis in patients with'riskorgan'multi-system Langerhans cell histiocytosis显示文摘 | BRAIER J L ROSSO D LATELLA A | 2010 | J Pediatr Hematol Oncol2010，32，： | 1 |
| 12 | Automatic Verification of a Behavioral Subset of UML Statechart Diagrams Using the SPIN Modelchecker显示文摘 | Latella D Majzik I Massink M | 1999 | Formal Aspects of Computing1999，，11： | 1 |
| 13 | Adhesion of glass to steel using a geopolymer显示文摘 | Latella B A Perera D S Escott T R | 2006 | Mater Sci2006，，41： | 1 |
| 14 | Increased prevalence of Helicobacter pylori in patients with diabetes mellitus显示文摘 | Marrollo M Latella G Melideo D | 2001 | Dig Liver Dis2001，33，1： | 1 |
| 15 | p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci显示文摘 | Simone C Forcales S V Hill D A Imbalzano A N Latella L Puri P L | | 0，，7： | 1 |
| 16 | Reduction in corticospinal inhibi- tion in the trained and untrained limb following unilateral leg strength training显示文摘 | Latella C Kidgell D J Pearee AJ | 2012 | Eur J App1 Physiol2012，112，8： | 1 |
| 17 | Increased prevalence of Helicobacter pylori in patients with diabetes mellitus显示文摘 | Marrollo M Latella G Melideo D | 2001 | Dig Liver Dis2001，33，1： | 1 |
| 18 | Increased prevalence of Helicobacter pylori in patients with diabetes mellitus显示文摘 | Marrollo M Latella G Melideo D | 2008 | Dig Liver Dis2008，33，1： | 1 |
| 19 | Virtual reality for Parkinson disease显示文摘BACKGROUND AND OBJECTIVE The prevalence of Parkinson's disease ( PD) in industrialized countries is 0.3% in the general population. This study evaluated the effects of virtual reality training ( VRT) on motor and cognitive recovery in patients with PD. | Maggio MG De Cola MC Latella D | 2019 | 中华物理医学与康复杂志2019，41，5： | 0 |
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