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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Studies of Aβ pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the γ-secretase inhibitor N^2- -N^1 - azepine-7-yl ] -L-alaninamide ( LY411, 575) 显示文摘 | LANZ T A HOSLEY J D ADAMS W J | 2004 | J Pharmacol Exp Ther2004，309，1： | 1 |
| 3 | Characterization of the stereoselective metabolism of methadone and its primary metabolite via cyclodextrin capillary electrophoretic determination of their urinary enantiomers显示文摘 | Lanz M Thormann W | 1996 | Electrophoresis1996，17，： | 1 |
| 4 | Nuclear Receptor Coregulators:Cellular and Molecularn显示文摘 | Lanz B Bert W O'Maller | 1997 | Biology Endocrine Reviews1997，20，3： | 1 |
| 5 | Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2--N 1-azepin-7-yl]-L-alaninamide (LY-411575)显示文摘 | LANZ TA HOSLEY JD ADAMS W J | 2004 | J Pharmacol Exp Ther2004，309，1： | 1 |
| 6 | Rapid determination of gemcitabine in plasma and serum using reversed-phase HPLC显示文摘 | Lanz C Fruh M Thormann W | 2007 | J Sep Sci2007，30，12： | 1 |
| 7 | Optical stethoscopy:Image recording with resolution λ/20显示文摘 | Pohl D W Denk W Lanz M | 1984 | Appl Phys Lett1984，44，7： | 1 |
| 8 | Capillary zone electrophoresis with a dynamic double coating for analysis of carbohydratedeficient transferrin in human serum:Impact of resolution between disialo- and trisialotransferrin on reference limits显示文摘 | Thormann W | 2003 | Electrophoresis2003，24，： | 1 |
| 9 | Nuclear receptor coregulators: cellular and molecularn显示文摘 | Lanz B Bert W O | 1997 | Biology Endocrine Reviews1997，20，3： | 1 |
| 10 | Optical Stethoscopy: Im- age Recording With Resolution /20 显示文摘 | Pohl D W Denk W Lanz M | 1984 | Applied PhysicsLetter1984，44，65： | 1 |
| 11 | Nuclear receptor coregulators:cellular and molecular biology显示文摘 | Mckenna N J Lanz R B O'alley B W | | 0，，3： | 1 |
| 12 | Characterization of the stereoselective metabolism of methadone and its primary metabolite via cyclodextrin capillary electrophoretic determination of their urinary enantiomers 显示文摘 | Lanz M Thormann W | 1996 | Electrophoresis1996，17，12： | 1 |
| 13 | Optical stethoscopy:image recording with resolution λ/20 显示文摘 | Pohl D W Denk W Lanz M | 1984 | Applied Physics Letters1984，44，： | 1 |
| 14 | Optical stethoscopy-image recording with resolution lambda/20显示文摘 | Pohl D W Denk W Lanz M | 1984 | Appl Phys Lett1984，44，7： | 1 |
| 15 | Partial discharge-part x:PD in gas-insulated substations-measurement and practical considerations显示文摘 | BAUMGARTNER R FRUTH B LANZ W | 1992 | IEEE Electrical Insulation Magazine1992，8，1： | 1 |
| 16 | Nuclear receptor coregulators and human disease显示文摘 | Lonard D M Lanz R B O'Malley B W | 2007 | Endocrine Reviews2007，28，5： | 1 |
| 17 | Very small ganglia as the cause of wrist pain显示文摘 | Lanz U Romen W | 1980 | Handchirurgie1980，12，12： | 1 |
| 18 | Opoical stethoscopy: image recording with resolution λ/20显示文摘 | Pohl D W Denk W Lanz M | 1984 | Appl Phys Lett1984，44，7： | 1 |
| 19 | Optical stethoscopy image recording with resolution λ/20显示文摘 | Pohl D W Denk W Lanz M | 1984 | Applied Physics Letters1984，44，65： | 1 |
| 20 | Optical stethoscopy:Image recording with resolution λ/20 显示文摘 | Pohl D W Denk W Lanz M | 1984 | Appl Phys lett1984，44，7： | 1 |
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