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| 1 | Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis显示文摘AIM:To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.METHODS:We performed a prospective study of 127patients who underwent endoscopic retrograde cholangiopancreatography,for various biliary disorders,at 3 tertiary referral centers in Germany from July 2011through July 2012(ClinicalTrials.gov:NCT01109550).Bile,buccal,and stool samples were collected.When indicated,endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.RESULTS:Candida species were detected in 38 of the 127 bile samples(29.9%).By multivariate analysis patients’age and previous endoscopic sphincterotomy were independent risk factors for biliary candidiasis(P<0.05).Patients with immunosuppression(P=0.058)and recent long-term antibiotic therapy(>7 d)(P=0.089)tend to be at risk for biliary candidiasis.One patient was negative in mycological culture of bile fluid but invasive biliary candidiasis was diagnosed histologically.Of Candida subspecies detected,36.7%were azole-resistant,such as C glabrata.Eight patients received anti-mycotic therapy,based on our algorithm.Of these,3 had cancer with biliary tract involvement,2had secondary sclerosing cholangitis,1 had retroperitoneal fibrosis,and 5 had septicemia.In all patients contamination was ruled out by smears of the endoscope channel.CONCLUSION:Gastroenterologists should be aware of frequent candida colonization in patients with cholangitis and biliary disorders.Our suggested algorithm facilitates the further clinical management. | Philipp Lenz Franziska Eckelskemper Thomas Erichsen Tim Lankisch Alexander Dechêne Gabriele Lubritz Frank Lenze Torsten Beyna Hansjorg Ullerich Andre Schmedt Dirk Domagk | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 2 | Growth-differentiation factor-15:a novel biomarker in patients with diastolic dysfunction?显示文摘 | Dinh W Füth R Lankisch M | 2011 | Arq Bras Cardiol2011，97，1： | 1 |
| 3 | Acute pancreatitis 显示文摘 | Lankisch PG Apte M Banks PA | 2015 | Lancet2015，386，9988： | 1 |
| 4 | Drug induced acute pancreatitis:incidence and severity 显示文摘 | Lankisch PG Droge M Gottesleben F | 1995 | Gut1995，37，4： | 1 |
| 5 | The Effect of Small Amounts of Alcohol on the Clinical Course of Chronic Pancreatitis显示文摘 | Mark R. Lankisch Mami Imoto Peter Layer Eugene P. DiMagno | 2001 | Mayo Clinic Proceedings2001，，3： | 1 |
| 6 | Treatment of acute pancreatitis: an attempted historical review显示文摘 | Lankisch PG | 2010 | Pathophysiology2010，10，2： | 1 |
| 7 | Do we need a computed tomography examination in all patients with acute pancreatitis within 72 h after admission to hospital for the detection of pancreatic neerosis显示文摘 | Lankisch P G Struckmann K Assmus C | 2001 | Scand J Gastroenterol2001，36，4： | 1 |
| 8 | The APACHE II score is unreliable to diagnose necrotizing pancreatitis on admission to hospital显示文摘 | Lankisch PG Warnecke B Bruns D | 2002 | Pancreas2002，24，3： | 1 |
| 9 | Hemoconcentration : an early marker of severe and/ornecrotizing pancreatitis? A critical appraisal 显示文摘 | Lankisch PG Mahlke R Blum T | 2001 | Am JGastroenterol2001，96，7： | 1 |
| 10 | Rapid Allelic Discrimination by TaqMan PCR for the Detection of the Gilbert’s Syndrome Marker UGT1A1*28显示文摘 | Ursula Ehmer Tim O. Lankisch Thomas J. Erichsen Sandra Kalthoff Nicole Freiberg Michael Wehmeier Michael P. Manns Christian P. Strassburg | 2008 | The Journal of Molecular Diagnostics2008，，6： | 1 |
| 11 | Pleural effusion:A new negative prognostic parameter for acute pancreas显示文摘 | Lankisch PG Droge M Becher R | 1994 | Am J Gastroenterol1994，89，： | 1 |
| 12 | Bile-induced acute experimental pancreatitis 显示文摘 | Lankisch PG lhse I | 1987 | Stand J Gastroenterol1987，22，2： | 1 |
| 13 | Bile-induced acute experimental pancre- atitis显示文摘 | Lankisch PG Ihse I | 1987 | Scand J Gastroenterol1987，22，3： | 1 |
| 14 | Recovery of the pancreas after acute pancreatitis is not necessarily complete显示文摘 | Frank Seidensticker Jutta Otto Paul G. Lankisch | 1995 | International Journal of Pancreatology1995，，3： | 1 |
| 15 | Exocrine pancreatic function in insulin-dependent diabetes mellitus显示文摘 | Lankisch P G Manthey G Otto J | 1982 | Digestion1982，25，3： | 1 |
| 16 | lAP Guidelines for the Surgical Management of Acute Pancreatitis显示文摘 | Uhl W Warshaw A Imrie C Bassi C McKay C J Lankisch PG Carter R Di Magno E Banks PA Whitcomb DC | 2002 | Panereatology2002，2，6： | 1 |
| 17 | Medical and endoscopictherapy of primary sclerosing cholangitis显示文摘 | Weismiiller TJ Lankisch TO | 2011 | Best Pract ResClin Gastroenterol2011，25，6： | 1 |
| 18 | Acute pancreatitis : does gender matter 显示文摘 | Lankisch PG Assmus C Lehnick D | 2001 | Dig Dis Sci2001，46，11： | 1 |
| 19 | Do we need a computed to mograp by examination in all patients with acute pancreatitis with in 72h after admission to hospital for the detection of pancreatic necrosis?显示文摘 | Lankisch PG Struckmann K Assmus C | 2001 | Scand J Gastroenterol2001，36，4： | 1 |
| 20 | G factor-15 : a novel biomarker in patients with diastolic dysfunction? 显示文摘 | Dinh W Futh R Lankisch M | 2011 | Arq Bras Cardiol2011，97，1： | 1 |
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