|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected smal hepatocel ular carcinomas显示文摘BACKGROUND:Hepatocellular carcinoma(HCC)is a highly malignant tumor with a poor prognosis.Because small HCCs possess most of the characteristics of early HCC,we investigated small HCCs to screen potential biomarkers for early diagnosis.METHODS:Proteins were extracted from 10 sets of paired tissue samples from HBV-infected small-HCC patients.The extracted proteins were well resolved by two-dimensional electrophoresis.These HCC-associated proteins were then identified by MALDI-TOF/TOF MS following image analysis.Western blotting and immunohistochemistry were used to assess glutamine synthetase(GS)and phenazine biosynthesislike domain-containing protein(PBLD)expression in liver tissue.Enzyme-linked immunosorbent assays in 152 serum samples(from 49 healthy donors,24 patients with liver cirrhosis,and 79 with HCC)were used to further assess the significance of GS clinically.RESULTS:Fifteen up-regulated and three down-regulated proteins were identified.Western blotting confirmed GS overexpression and decreased PBLD expression in liver tissue.Immunohistochemistry showed that GS was expressed in 70.0%(84/120)of HCCs and 35.8%(43/120)of nontumor tissues;PBLD was expressed in 74.2%(89/120) of nontumor tissues and 40.8%(49/120)of HCCs.The Chi-square test showed significant expression differences between HCCs and adjacent tissues.Consistent with this,serum GS levels in HCC patients were significantly higher than those in liver cirrhosis patients and healthy donors,while the latter two groups were also significantly different.In addition, a diagnostic cutoff value of 2.6 mg/ml was used for GS;it was elevated in 19(76.0%)of 25 HCC patients with AFP≤20 ng/ml and 47(88.7%)of 53 HCC patients with AFP≤200 ng/ml.CONCLUSION:GS and PBLD are abnormally expressed in most HCCs.GS may be a novel serum marker for early HCC, especially for those patients with low AFP levels(≤200 ng/ml). | Jiang Long,Zhen-Wei Lang,Hua-Guang Wang,Tai-Ling Wang,Bao-En Wang and Si-Qi Liu Liver Research Center,Beijing Friendship Hospital, Capital Medical University,Beijing 100050,China Department of Hepatology,Department of Pathology, Beijing Youan Hospital,Capital Medical University,Beijing 100069,China Department of Pharmaceutical Affairs,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China Department of Pathology,China-Japan Friendship Hospital,Beijing 100029,China Beijing Genomics Institute,Chinese Academy of Science,Beijing Airport Industrial Zone B-6,Shunyi,Beijing 101300,China | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 21 |
| 2 | EFFECTS OF SPECIFIED BLANK SIZE ON BODY WRINKLING DURING HYDRODYNAMIC DEEP DRAWING OF TAPERED RECTANGULAR BOX显示文摘In this paper, the forming features of tapered rectangular box during hydrodynamic deep drawing are studied by means of FEM.The effect rules of square blank corner corner amount on body wrinkling are recognized and corresponding methods are discussed. At last, the results of FEM are verified by experi- ment. | L. H. Lang, D. C. Kang, S. H. Zhang, Z. R. Wang, S. J. Yuan, K. B. Nielsen and J. Dancket 1) Department of Materials Engineering, Harbin Institute of Technology, Harbin 150001, China 2) Aalberg University, Denmark | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 21 |
| 3 | Effects of chlorothalonil and carbendazim on nitrification and denitrification in soils显示文摘The effects of chlorothalonil and carbendazim on nitrification and denitrification in six soils in upland and rice paddy environments were investigated. Laboratory aerobic (60% water holding capacity) and anaerobic (flooded) conditions were studied at 25°C and fungicide addition rates of 5.5 mg/kg A. I. (field rate, FR), 20 times (20FR) and 40 times (40FR) field rate, respectively. The results indicated that chlorothalonil at the field rate had a slight inhibitory effect on one soil only, and that soil did not nitrify much in the first place. But chlorothalonil at higher rates inhibited nitrification significantly in all soils. For soils JXP and JXU with a pH of less than 5.0, chlorothalonil almost completely stopped their nitrification at 20FR and 40FR during the whole 14 d incubation period. For soils HNP and HNU with a pH of greater than 8.0, chlorothalonil also significantly inhibit nitrification at 20FR and 40FR (p < 0.05). However, NH4+ that was added to the soil was also almost completely nitrified by the end of the incubation period in these two soils. The effects of chlorothalonil at 20FR and 40FR on the nitrification of JSP and JSU soils, with a pH of 5.4 and 7.2, respectively, were intermediate between the other soil types. Chlorothalonil had no effect on denitrification at the field rate and had little effect at the higher rates of application in some soils. Carbendazim had essentially no effect on nitrification and denitrification in soils assessed. | LANG Man, CAI Zucong State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences,Nanjing 210008, China | 2009 | Journal of Environmental Sciences2009，21，4： | 14 |
| 4 | Extraseasonal ensemble numerical predictions of winter climate over China显示文摘Using the nine-level Atmospheric General Circulation Model developed at the Institute of Atmospheric Physics (IAP9L-AGCM) under the Chinese Academy of Sciences, 30-year extraseasonal short-term ensemble hincast of winter climate is performed, with integrations starting from annual autumn during 1969—1998. Winter climate predictability over China is then evaluated for the first time. It follows that the predictability is higher in tropics than in extratropics. Also, it is higher over ocean compared with land, especially for surface air temperature. With height increasing in troposphere, the predictability of geopotential height slightly changes zonally, but for weakening of band-ship distribution and dropping near the date line. Of all analyzed variables, the prediction skill of air temperature and geopotential height (precipitation) is the highest (smallest). In addition, the predictability of winter climate over China and even East Asia enhances obviously during ENSO cycle, especially during La Nia phase. Simulation comparison against verifying analysis for surface temperature anomaly exhibits the model抯 skill in predicting surface temperature抯 interannual variation trend in winter. | LANG Xianmei, WANG Huijun & JIANG Dabang Nansen-Zhu International Research Center and LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2003 | Chinese Science Bulletin2003，48，19： | 14 |
| 5 | A tetrahedral data model for unstructured data management显示文摘This paper proposes a tetrahedral data model for unstructured data management. The model defines the four components of unstructured data including: basic attributes, semantic characteristics, low-level features and raw data on its four facets, and the relations between these components. The internal implementation structure of the model and the data query language are designed and briefly introduced. This model provides a unified, integrated and associated description for different kinds of unstructured data, and supports intelligent data services such as associated retrieval and data mining. An example is given to demonstrate how to use the model for describing and manipulating data from a sample video base. | LI Wei & LANG Bo State Key Laboratory of Software Development Environment, Beihang University, Beijing 100191, China | 2010 | Science China(Information Sciences)2010，53，8： | 13 |
| 6 | Changes in serum and histology of patients with chronic hepatitis B after interferon alpha-2b treatment显示文摘AIM: Chronic hepatitis B is a serious health problem.Interferon has long been used to treat Chronic hepatitis B.To evaluate the effects of interferon on chronic hepatitis Bbetter, we designed the study to investigate the changes insera and liver histology of patients with chronic hepatitis Bafter interferon alpha-2b treatment.METHODS: Twenty-four patients with chronic hepatitis Bwere enrolled in this study. They all received interferon alpha-2b treatment as following: 3 million units, i.m.. t.i.w., for 18weeks. Sera of all patients were obtained respectively forevaluation of ALT, HBsAg, HBcAg, HBeAg, HBV DNA andTIMP-1 before and afterinterferon treatment, also a liverbiopsy pre- and post-treatment was performed forcomparison of HAI, HBsAg, HBcAg, HBeAg, TIMP-1 andactivated HSC in the liver tissue.RESULTS: Patients who had normalization of serum ALTand seroconversion of HBeAg and/or HBV DNA (blothybridization) after treatment were defined as responders.The response rate in this study group was 37.5 % (7/24).Compared to pretreatment, the serum HBV DNA and TIMP-1 decreased significantly (P<0.05), so did the HAI, HBo Ag,HBeAg, TIMP-1 and activated HSC (P<0.05).CONCLUSION: The significant decrease in HBV DNA insera, the seroconversion of HBeAg, and the decrease ofviral expression in liver indicated that interferon alpha-2btreatment can inhibit viral replication. The normalization ofALT in sera and the improvement of HAI in liver showedthat interferon alpha-2b can improve the liver histology ofpatients with chronic hepatitis B. At the same time, interferonalpha-2b treatment can reduce the TIMP-1 in serum andliver and decrease the number of activated HSC, which mayallievate or inhibit hepatic fibrosis. Although the responserate was unsatisfactory, interferon play a benefical role onpatients with chronic hepatitis B in other respects. We stillneed further studies to improve the therapy effects. | Hong-Lei Han Zhen-Wei Lang Department of Pathology,Beijing Youan Hospital,Beijing 100054,Beijng City,China | 2003 | World Journal of Gastroenterology2003，9，1： | 12 |
| 7 | Prediction model for spring dust weather frequency in North China显示文摘It is of great social and scientific importance and also very difficult to make reliable prediction for dust weather frequency (DWF) in North China. In this paper, the correlation between spring DWF in Beijing and Tianjin observation stations, taken as examples in North China, and seasonally averaged surface air temperature, precipitation, Arctic Oscillation, Antarctic Oscillation, South Oscillation, near surface meridional wind and Eurasian westerly index is respectively calculated so as to construct a prediction model for spring DWF in North China by using these climatic factors. Two prediction models, i.e. model-I and model-II, are then set up respectively based on observed climate data and the 32-year (1970 -2001) extra-seasonal hindcast experiment data as reproduced by the nine-level Atmospheric General Circulation Model developed at the Institute of Atmospheric Physics (IAP9L-AGCM). It is indicated that the correlation coefficient between the observed and predicted DWF reaches 0.933 in the model-I, suggesting a high prediction skill one season ahead. The corresponding value is high up to 0.948 for the subsequent model-II, which involves synchronous spring climate data reproduced by the IAP9L-AGCM relative to the model-I. The model-II can not only make more precise prediction but also can bring forward the lead time of real-time prediction from the model-I’s one season to half year. At last, the real-time predictability of the two models is evaluated. It follows that both the models display high prediction skill for both the interannual variation and linear trend of spring DWF in North China, and each is also featured by different advantages. As for the model-II, the prediction skill is much higher than that of original approach by use of the IAP9L-AGCM alone. Therefore, the prediction idea put forward here should be popularized in other regions in China where dust weather occurs frequently. | LANG XianMei Center for Disastrous Climate Research and Prediction, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2008 | Science China Earth Sciences2008，51，5： | 10 |
| 8 | The discrete multiple-parameter fractional Fourier transform显示文摘As a generalization of the Fourier transform (FT), the fractional Fourier transform (FRFT) has many applications in the areas of optics, signal processing, information security, etc. Therefore, the efficient discrete computational method is the vital fundament for the application of the fractional Fourier transform. The multiple-parameter fractional Fourier transform (MPFRFT) is a generalized fractional Fourier transform, which not only includes FRFT as special cases, but also provides a unified framework for the study of FRFT. In this paper, we present in detail the discretization method of the MPFRFT and define the discrete multiple-parameter fractional Fourier transform (DMPFRFT). Then, we utilize the tensor product to define two-dimensional multiple-parameter fractional Fourier transform (2D-MPFRFT) and the corresponding two-dimensional discrete multiple-parameter fractional Fourier transform (2D-DMPFRFT). Finally, as an application, a novel image encryption method based on 2D-DMPFRFT is proposed. Numerical simulations are performed to demonstrate that the proposed method is reliable and more robust to blind decryption than several existing methods. | LANG Jun, TAO Ran& WANG Yue Department of Electronic Engineering, Beijing Institute of Technology, Beijing 100081, China | 2010 | Science China(Information Sciences)2010，53，11： | 8 |
| 9 | Clinicopathological study on TTV infection in hepatitis of unknown etiology显示文摘AIM: To investigate the state of infection, replication site,pathogenicity and clinical significance of transfusiontransmitted virus (TTV) in patients with hepatitis, especiallyin patients of unknown etiology.METHODS: Liver tissues taken from 136 cases of non-A non-G hepatitis were tested for Tr virus antigen and nucleic acidby in situ hybridization (ISH) and nested-polymerase chainreaction (PCR). Among them, TT virus genome and itscomplemental strand were also detected in 24 cases ofautopsy liver and extrahepatic tissues with ISH. Meanwhile,TTV DNA was detected in the sera of 187 hepatitis patientsby nested-PCR. The pathological and clinical data of thecases infected with nv only were analyzed.RESULTS: In liver, the total positive rate of rrv DNA was32.4 % and the positive signals were located in the nuclei ofhepatocytes. In serus, rrv DNA was detected in 21. 4 %cases of hepatitis A-G, 34.4 % of non-A non-G hepatitis and15 % of healthy donors. The correspondence rate of lrvDNA detection between liver tissue with ISH and sera withPCR was 63.2 % and 89.3 % in the same liver tissues by ISHand by PCR, respectively. Using double-strand probes andsingle-strand probes designed to detect TTV genome, thecorrespondence rate of Trv DNA detected in liver andextrahepatic tissues was 85. 7 %. Using single-strandprobes, TTV genome could he detected in liver andextrahepatic tissues by PCR, but its complemental strands(replication strands) could be observed only in livers. Theliver function of most cases infected with TTV alone wasabnormal and the liver tissues had different pathologicaldamage such es ballooning, acidophilia degeneration,formation of apoptosis bodies and focus of necrosis, but the inflammation in the Iobule and portal area was mild.CONCLUSION: The positive rate of TTV DNA among cases ofhepatitis was higher than that of donors, especially inpatients with nonA non-G hepatitis, but most of them werecoinfected with other hepatitis viruses. Lrv can infect notonly hepatocytes, but also extrahepstic tissues. However,the chief replication place may be liver. The infection of lrvmay have some pathogenicity. Although the pathogenicity iscomparatively weak, it can still damage the liver tissues.The lesions in acute hepatitis (AH) and chronic hepatitis(CH) am mild, but in severe hepatitis (SH) , it can be veryserious and cause liver function failure, therefore, we shouldpay more attention to TTV when studying the possiblepathogens of so-called 'liver hepatitis of unknown etiology'. | Zhong-Jie Hu Zhen-Wei Lang Yu-Sen Zhou Hui-Ping Yan De-Zhuang Huang Wan-Rong Chen Zhao-Xia Luo,Department of Pathology,Beijing You’an Hospital,Beijing 100054,China | 2002 | World Journal of Gastroenterology2002，8，2： | 6 |
| 10 | A computational trust model for access control in P2P显示文摘Trust brings a new method for building scalable and fine-grained access control mechanism in P2P systems. The quantificational expression of trust and the calculation of trust in a trust network are the basis of trust degree based access control. In this paper, the properties of trust is analyzed by referring to the fruits from social science; the semantics of trust in the context of access control is described, and a trust degree based access control model named TDBAC is introduced. Basing on the properties and semantics of trust, a computational trust model which includes a multilevel comprehensive evaluation method for expressing direct trust and calculators for computing recommended trust is put forward. To compute trust in a trust network, an algorithm that transforms a trust network to a computable expression is given. The algorithm simplifies the computation process and is also flexible. | LANG Bo State Key Laboratory of Software Development Environment, Beihang University, Beijing 100191, China | 2010 | Science China(Information Sciences)2010，53，5： | 6 |
| 11 | Representation of Integers by Ternary Quadratic Forms | De Lang LI Chun Lai ZHAO Department of Mathematics, Sichuan University, Chengdu 610064, P. R. China Department of Mathematics, Peking University, Beijing 100871, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 3 |
| 12 | Studies on solid state reactions of coordination compounds LI.Solid state syntheses of a family of Ag-Mo(W)-S cubane-like cluster compounds:Crystal structures of{Ag_3MoS_3I}(PPh_3)_3S and{Ag_3WS_3Cl}(PPh_3)_3S·0.5P(S)Ph_3·3H_2O^+显示文摘Reactions of[NH4]2[MS4](M=Mo,W),AgX(X=Cl,Br,I,CN,SCN)and PPh3in the solid state produced six new mixed-metal sulfur containing cluster compounds,two ofwhich,{Ag3MoS3I}(PPh3)3S(1)and{Ag3WS3Cl}(PPh3)3S·0.5P(S)Ph3·3H2O(2),were determinedby single crystal X-ray analysis.The crystal data:1,triclinic,P,a=12.114(2),b=13.420(2),c=20.346(3),α=74.53(1),β=86.73(1),γ=63.74(1)°,Z=2,R=0.043 for 4805 independentdata;2,hexagonal,R3,a=b=16.201(3),c=45.091(10),Z=6,R=0.042 for 2729 independentdata.The central unit{Ag3MS3X}(M=Mo,W;X=Cl,I)of the two compounds can be des-cribed as a slightly distorted cube,four corners being formed by the MS42- ligand(with a ter-minal S atom).The remaining corners are occupied by one X(Cl or I)atom and three Agatoms(with one PPh3 ligand bound to each of the latter).The generation of different types ofAg-Mo(W)-S cluster compounds prepared from solid state reactions under different reactiontemperatues is discussed. | LANG,Jian-Ping BAO,Shi-An ZHU,Hui-Zhen XIN,Xin-Quan Coordination Chemistry Institute,Nanjing University,Nanjing 210008YU,Kai-Bei Chengdu Center of Analysis and Measurement,Chinese Academy of Sciences,Ckengdu 610015 | 1993 | Chinese Journal of Chemistry1993，11，2： | 2 |
| 13 | Flocking shape analysis of multi-agent systems显示文摘In this paper,we consider the shape control in flocking behavior of a multi-agent system with a virtual leader.Besides the traditional flocking control terms,which include a gradient-based term,a velocity consensus term and a navigational feed-back in general,a new piecewise smooth neighbor-based local controller is added to regulate the configuration to the desired flocking shape.All agent velocities approach the desired velocity asymptotically,while collisions among agents can be avoided.Furthermore,based on the proved stability,we obtain three kinds of flocking shapes,such as those in a single line,vee shape or corner shape.Some numerical simulation results are provided to demonstrate theoretical issues. | YANG JiChen,LU QiShao &LANG XiuFeng Department of Dynamics and Control,Beihang University,Beijing 100191,China | 2010 | Science China(Technological Sciences)2010，53，3： | 2 |
| 14 | A Novel Computerized Water Level Control System of PWR Steam Generator of Nuclear Power Plant显示文摘NomenclaturesAArea(m2)EEnergyControl(J)fPressureLossCoeficientaVoidFractionHSpecificEnthaply(J/kg)IInertance(m)KFrictionLossC... | M.Tahir Khaleeq Lang Wenpen He Guosen (School of Automation) | 1998 | Advances in Manufacturing1998，，3： | 1 |
| 15 | Clinical research in implant dentistry: evaluation of implant- supported restorations, aesthetic and patient-reported outcomes显示文摘 | Lang NP Zitzmann NU Working Group 3 of the VEWoP | 2012 | J Clin Periodontol2012，39，12： | 1 |
| 16 | Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set显示文摘 | Warner LR Varga K Lange OF Baker SL Baker D Sousa MC Pardi A | | 0，，01： | 1 |
| 17 | Construction of [Cu_nI_n]-based coordination polymers via flexible benzimidazolyl-based ligands显示文摘Four new [CunIn]-based coordination polymers, [{Cu4(μ3-I)4(mbbm)2}·2DMF]n (1), [(CuI)2(mbbm)2]n (2), [{Cu2(μ-I)2-(ebbm)2}·2MeCN]n (3), and [Cu2(μ-I)2(prbbm)2]n (4), were prepared from solvothermal reactions of CuI with three flexible ligands [(bzim)(CH2)n(bzim)] (bzim = benzimidazole; n = 1, mbbm; n = 2, ebbm; n = 3, prbbm). These compounds were characterized by elemental analysis, IR and X-ray crystallography. 1 consists of cubanelike [Cu4(μ3-I)4] fragments that link the neighboring ones via mbbm bridges to form a 1D ladder-type chain. 2 contains mononuclear [CuI] fragments that are bridged by mbbm ligands to yield a 1D zigzag chain. 3 or 4 contains a [Cu2(μ-I)2] dimeric fragment, which works as a four-connecting node to link its four equivalent ones to form a 2D (4,4) network (3) or acts as a two-connecting node to connect its two equivalent ones via two pairs of prbbm bridges to form a 1D double chain (4). The photoluminescent properties of 1-4 in the solid state at ambient temperature were investigated. | LI LingLing, REN ZhiGang, Lü Xue, WANG HeMing, CHANG YuJie, LI HongXi, WU Bing & LANG JianPing College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, China | 2010 | Science China Chemistry2010，53，10： | 1 |
| 18 | Simultaneous radiotherapy dnd chemotherapy in the treatment of brain metastases of malignant solid tumours显示文摘 | Schlechtingen J Haase KD | 1987 | Int J Clin Pharmacol Res(Switzerland)1987，7，5： | 1 |
| 19 | ACUPUNCTURE TREATMENT OF 280 CASES OF BULBAR PARALYSIS OF UPPER MOTOR NEURONS显示文摘The hulbar paralysis of upper rnotor neurons is a common seniIe disease. ln recentycars. we select Lianquan (CV 23 ) as a chief point in comhination with Jinjin (EX-HN l2 ). Yuye(FX-HN 13 ) and Zhaohai (KI 6 ) and employ uniform reinforcing-reducing manipuIation to treat 280patients. The results show that a total effectivc rate is 55. 71%. The possible mechanisms are dis-cussed preliminarily in thc present paper. | Zhang Weige, Wu Gulping. Zhang XiuxiaDepartment of Neurology, People’s Hospital of Lang Jang Municipality,Hebei 102800, ChinaQiu ZhenshanGudcke Medicine and Health Article Limited Company, Lang fang Municipality, Hebei 102800, China | 1995 | World Journal of Acupuncture-Moxibustion1995，5，2： | 1 |
| 20 | The revised CONSORT statement for reporting randomized trials:explanation and elaboration显示文摘 | Altman DG Schulz KF Moher D Egger M Davidoff F Elbourne D Gotzsche PC Lang T CONSORT GROUP (Consolidated Standards of Reporting Trials) | | 0，，08： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员