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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 3 | Signal and construction mechanisms for activation of plant defenses against microbial attack显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 2 |
| 4 | Frequent downregulation of KAI1/CD82 metastasis suppressor protein in human cancer cell lines 显示文摘 | Write A Lamb PW Barrett JC | 1998 | Oncogene1998，16，24： | 1 |
| 5 | The oxidative busrt in Plant disease re- sistance 显示文摘 | Lamb C Dixon R A | 1997 | Annual Review of Plant Physiology and Plant Mo- lecular Biology1997，48，： | 1 |
| 6 | Barriers and facilitators to consulting hospital clinical ethics committees显示文摘 | Gaudine A Lamb M LeFort SM | 2011 | Nurs Ethics2011，18，6： | 1 |
| 7 | Reverse genetics of negative-strand RNA viruses:Closing the circle显示文摘 | Pekosz A He B Lamb R A | 1999 | Proc Natl Acad Sci1999，96，16： | 1 |
| 8 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 9 | Sulfur emissions to the atmosphere from natural sources显示文摘 | Bate T S Lamb B K Guenther A | 1992 | Journal of Atmospheric Chemistry1992，14，： | 1 |
| 10 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 11 | Mizolastime:Areview of its use im allergic rninitis and chronic idiopathic urticaria 显示文摘 | Prakash A Lamb HM | 1998 | Biodvug1998，10，1： | 1 |
| 12 | Trends in the use and capacity of California's emergency departments, 1990- 1999显示文摘 | Lambe S Washington DL Fink A | 2002 | Ann Emerg Med2002，39，4： | 1 |
| 13 | Movement of Pseudomonas aureofaciens from the rhizosphere to aerial plant tissue显示文摘 | Lamb T G Tonkyn D W Kluepfel D A | 1996 | Canadian Journal of Microbiology1996，42，11： | 1 |
| 14 | Cancers coinciding with childbear- ing: delayed diagnosis during pregnancy?显示文摘 | Lambe M Ekbom A | 1995 | BMJ1995，311，7020： | 1 |
| 15 | The Oxidative Burst in Plant Disease Resistance 显示文摘 | LAMB C DIXON R A | 1997 | Annu Rev Plant Mol Biol1997，48，： | 1 |
| 16 | Restoration of degraded tropical forest landscapes 显示文摘 | Lamb D Erskine P D Parrotta J A | 2005 | Science2005，310，： | 1 |
| 17 | Antimicrobial activity of flavonoids 显示文摘 | Cushnie T P T Lamb A J | 2005 | International Journal of Antimicrobial Agents2005，26，： | 1 |
| 18 | New 40Ar/39Ar age data and implications for porphyry copper deposits of Mongolia显示文摘 | LAMB M A COX D | 1998 | Economic Geology1998，92，： | 1 |
| 19 | Left ventricular remodeling early after aortic valve replacement:differential effects on diastolic function in aortic valve stenosis and aortic regurgitation显示文摘 | LAMB H J BEYERBACHT H P ROOS A D | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 20 | Impact of manure application on soil phosphorus sorption characterisitics and subsequent water quality implications显示文摘 | Laboski C A M Lamb J A | 2004 | Soil Science2004，169，6： | 1 |
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