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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Signal and construction mechanisms for activation of plant defenses against microbial attack显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 2 |
| 3 | Programmed cell death in plants 显示文摘 | PENNELL R I LAMB C | 1997 | Plant Cell1997，9，： | 1 |
| 4 | Expression ofa reflex of snapping/biting response to amino acids prior to the first exogenous feeding in salmonid alevins显示文摘 | Valentin(c)i(c) T B Lamb C F Caprio J | 1999 | Physiol Behav1999，67，4： | 1 |
| 5 | Chicken growth hormone sequence显示文摘 | Lamb C I | 1988 | Nucl Acids Res1988，16，19： | 1 |
| 6 | Elicitor induced and wound induced oxidative cross-linking of a proline rich plant-cell wall protein:a novel,rapid defense response显示文摘 | BRADLEY D J KJELLOOM P LAMB C J | 1992 | Cell1992，70，1： | 1 |
| 7 | The oxidative busrt in Plant disease re- sistance 显示文摘 | Lamb C Dixon R A | 1997 | Annual Review of Plant Physiology and Plant Mo- lecular Biology1997，48，： | 1 |
| 8 | Phase-trans- fer catalysis in supercritical carbon dioxide: kinetic and mechanistic investigations of cyanide displacement on benzyl chloride 显示文摘 | Chandler K Culp C W Lamb D R | 1998 | Industrial & Engineering Chemis- try Research1998，37，8： | 1 |
| 9 | Use of the Dumon Y- stent in the management of malignant disease involving the carina:a retrospective review of 86 patients 显示文摘 | Dutau H Toutblanc B Lamb C | 2004 | Chest2004，126，3： | 1 |
| 10 | Hip fractures in institutionalized elderly people:incidence rates and excess mortality 显示文摘 | Rapp K Becker C Lamb SE | 2008 | J Bone Miner Res2008，23，11： | 1 |
| 11 | Hip fractures in institu- tionalized elderly eople: incidence rates and excess mortality 显示文摘 | Rapp K Becker C Lamb SE | 2008 | J Bone Miner Res2008，23，11： | 1 |
| 12 | Alliance competence,resources,and alliance success:Conceptualization,measurement,and initial test显示文摘 | LAMBE C J SPEKMAN R E HUNT S D | 2002 | Academy of Marketing Science2002，30，2： | 1 |
| 13 | Alliance Competence, Resources, and Alliance Success: Conceptualization, Measurement, and Initial Test显示文摘 | Lambe C J Spekman R E Hunt S D | 2002 | Journal of the Academy of Marketing Science2002，30，2： | 1 |
| 14 | The Oxidative Burst in Plant Disease Resistance 显示文摘 | LAMB C DIXON R A | 1997 | Annu Rev Plant Mol Biol1997，48，： | 1 |
| 15 | Internalmuhi - channel conflict: An exploratory investigation and conceptual framework 显示文摘 | Webb KL Lambe C J | 2007 | In2 dustrialMarketingManagement2007，36，1： | 1 |
| 16 | Impact of manure application on soil phosphorus sorption characterisitics and subsequent water quality implications显示文摘 | Laboski C A M Lamb J A | 2004 | Soil Science2004，169，6： | 1 |
| 17 | The oxidative burst in plant disease re- sistance 显示文摘 | LAMB C J DIXON R A | 1997 | Plant Mol Biol1997，48，： | 1 |
| 18 | The oxidative burst in plant disease resist- ance显示文摘 | Lamb C Dixon H A | 1997 | Ann Rev Plant Mol Biol1997，，48： | 1 |
| 19 | The oxidative burst in plant disease resistance显示文摘 | Lamb C J Dixon R A | 1997 | Annu Rev Plant Physiol1997，76，： | 1 |
| 20 | Cryopreservation of embryos and ova显示文摘 | Friedler S Giudice L C Lamb E J | 1988 | Fertil Sertil1988，49，： | 1 |
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