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| 1 | Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery显示文摘Natural bone constitutes a complex and organized structure of organic and inorganic components with limited ability to regenerate and restore injured tissues,especially in large bone defects.To improve the reconstruction of the damaged bones,tissue engineering has been introduced as a promising alternative approach to the conventional therapeutic methods including surgical interventions using allograft and autograft implants.Bioengineered composite scaffolds consisting of multifunctional biomaterials in combination with the cells and bioactive therapeutic agents have great promise for bone repair and regeneration.Cellulose and its derivatives are renewable and biodegradable natural polymers that have shown promising potential in bone tissue engineering applications.Cellulose-based scaffolds possess numerous advantages attributed to their excellent properties of non-toxicity,biocompatibility,biodegradability,availability through renewable resources,and the low cost of preparation and processing.Furthermore,cellulose and its derivatives have been extensively used for delivering growth factors and antibiotics directly to the site of the impaired bone tissue to promote tissue repair.This review focuses on the various classifications of cellulose-based composite scaffolds utilized in localized bone drug delivery systems and bone regeneration,including cellulose-organic composites,cellulose-inorganic composites,cellulose-organic/inorganic composites.We will also highlight the physicochemical,mechanical,and biological properties of the different cellulose-based scaffolds for bone tissue engineering applications. | Mahsa Janmohammadi Zahra Nazemi Amin Orash Mahmoud Salehi Amir Seyfoori Johnson V.John Mohammad Sadegh Nourbakhsh Mohsen Akbari | 2023 | Bioactive Materials2023，，2： | 3 |
| 2 | 无硫化物脱毛——臭氧脱毛的研究显示文摘不采用硫化物进行脱毛一直是制革研究的热点,意义不同寻常。氧化脱毛得到研究者普遍的关注。本文详细介绍了臭氧脱毛效果及臭氧脱毛对皮革物化性质的影响。基于臭氧体系可以达到完全的脱毛效果并且能够产生一定的经济效益。 | V.John Sunder N.Vedaraman P.A.Balakrishnan 王睿(编译) | 2007 | 北京皮革(中外皮革信息版)(中)2007，，2： | 1 |
| 3 | Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain显示文摘 | H. F.Dovey V.John J. P.Anderson L. Z.Chen P.De Saint Andrieu L. Y.Fang S. B.Freedman B.Folmer E.Goldbach E. J.Holsztynska K. L.Hu K. L.Johnson‐Wood S. L.Kennedy D.Kholodenko J. E.Knops L. H.Latimer M.Lee Z.Liao I. M.Lieberburg R. N.Motter L. C.Mutter J.Ni | 2009 | Journal of Neurochemistry2009，，1： | 1 |
| 4 | Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications显示文摘Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field. | Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou | 2024 | Military Medical Research2024，11，1： | 0 |
| 5 | Liver cancer understaging in liver transplantation in the current era of radiologic imaging and newer generation locoregional therapies显示文摘Background:Discordance in hepatocellular carcinoma(HCC)staging between pre-transplant imaging and explant pathology is associated with an increased risk of recurrence and death.Our aim was to evaluate variables that predicted concordance/discordance in the era of new generation locoregional therapies(LRT)and improved radiologic technology in diagnosis.Methods:A single-center retrospective study was performed on patients who received a liver transplant for HCC between 2008-2019.Pre-and post-LT variables,including type of LRT,downstaging(DS),transplant time period,and radiologic response to LRT,were analyzed for concordance/discordance.Kaplan-Meier analysis was used to assess post-LT survival.Results:Of 146 patients transplanted within Milan Criteria(MC),discordance rates(understaged)were 45%.Discordance was associated with≥3 HCC lesions at diagnosis but not newer generation LRT(transarterial radioembolization/stereotactic body radiation therapy),traditional LRT or combination.No differences in discordance were seen between transplant periods(2008-2013 vs.2014-2019),but those within MC in the earlier period had higher concordance rates.A trend was observed between DS and discordance.Conclusion:HCC stage discordance remains common and poorly predictable.Discordance was associated with three or more HCC lesions at the time of diagnosis.Patients within MC transplanted between 2008-2013 was associated with concordance,while a trend was noted between DS and discordance.No other pre-or post-LT variables predicted discordance/concordance.Discordance was associated with decreased survival. | Hannah M.Lee Donna McClish Binu V.John Sarah Winks Ryan Clayton Somaya Albhaisi Allawy Allawy Samarth Patel Emma C.Fields Scott Matherly Brian Strife Chandra Bhati Amit Sharma Richard K.Sterling | 2022 | Hepatoma Research2022，8，1： | 0 |
| 6 | Recent advances in biopolymer-based hemostatic materials显示文摘Hemorrhage is the leading cause of trauma-related deaths,in hospital and prehospital settings.Hemostasis is a complex mechanism that involves a cascade of clotting factors and proteins that result in the formation of a strong clot.In certain surgical and emergency situations,hemostatic agents are needed to achieve faster blood coagulation to prevent the patient from experiencing a severe hemorrhagic shock.Therefore,it is critical to consider appropriate materials and designs for hemostatic agents.Many materials have been fabricated as hemostatic agents,including synthetic and naturally derived polymers.Compared to synthetic polymers,natural polymers or biopolymers,which include polysaccharides and polypeptides,have greater biocompatibility,biodegradability and processibility.Thus,in this review,we focus on biopolymer-based hemostatic agents of different forms,such as powder,particles,sponges and hydrogels.Finally,we discuss biopolymer-based hemostatic materials currently in clinical trials and offer insight into next-generation hemostats for clinical translation. | Marvin Mecwan Jinghang Li Natashya Falcone Menekse Ermis Emily Torres Ramon Morales Alireza Hassani Reihaneh Haghniaz Kalpana Mandal Saurabh Sharma Surjendu Maity Fatemeh Zehtabi Behnam Zamanian Rondinelli Herculano Mohsen Akbari Johnson V.John Ali Khademhosseini | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 7 | Floating production storage and offloading systems' cost and motion performance: A systems thinking application显示文摘Floating production storage and offloading(FPSO) units increasingly represent a practical and economic means for deep-water oil extraction and production. Systems thinking gives a unique opportunity to seek a balance between FPSO technical performance(s),with whole-cost; stakeholder decision-making is charged to align different fit-for-use design specification options' that address technical-motion(s), with respective life-cycle cost analyses(LCCA). Soft system methodology allows situation based analyses over set periods-of-time by diagnosing the problem-at-hand; namely, assessing the antecedents of life-cycle cost relative to FPSO subcomponent design alternatives. Alternative mooringcomponent comparisons for either new-build hulls or refurbished hulls represent an initial necessary consideration to facilitate extraction, production and storage of deepwater oil reserves. Coupled dynamic analysis has been performed to generate FPSO motion in six degrees of freedom using SESAM DeepC, while life-cycle cost analysis(LCAA) studies give net-present-value comparisons reflective of market conditions. A parametric study has been conducted by varying wave heights from 4 – 8 m to understand FPSO motion behavior in the presence of wind and current, as well as comparing the motions of turreted versus spread mooring design alternatives. LCCA data has been generated to compare the cost of such different mooring options/hull conditions over 10 and 25-year periods. Systems thinking has been used to explain the interaction of problem variables; resultantly this paper is able to identify explicit factors affecting the choice of FPSO configurations in terms of motion and whole-cost,toward assisting significantly with the front-end engineering design(FEED) phase of fit-for-purpose configured FPSOs, in waters off Malaysia and Australia. | Rini NISHANTH Andrew WHYTE V.John KURIAN | 2018 | Frontiers of Engineering Management2018，5，3： | 0 |
| 8 | 考虑拆解的老龄固定式离岸平台条件评估技术的历史回顾显示文摘In this study,the technical papers on structural condition assessment of aged fixed-type offshore platforms reported over the past few decades are presented.Other ancillary related works are also discussed.Large numbers of researches are available in the area of requalification for life extension of offshore jacket platforms.Many of these studies involve reassessment of existing platforms by means of conducting pushover analysis,a static nonlinear collapse analysis method to evaluate the structure nonlinear behaviour and capacity beyond the elastic limit.From here,the failure mechanism and inherent reserve strength/capacity of the overall truss structure are determined.This method of doing reassessment is described clearly in the industry-adopted codes and standards such the API,ISO,PTS and NORSOK codes.This may help understand the structural behaviour of aged fixed offshore jacket structures for maintenance or decommissioning. | Mohamed Mubarak Abdul Wahab V.John Kurian Mohd Shahir Liew Do Kyun Kim | 2020 | Journal of Marine Science and Application2020，19，4： | 0 |
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