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| 1 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 2 | Carbonate cement at ion in a sequence- stratigraphic framwork: Upper Cretaceous sandstones,Book Cliffs,Utah-Colorado 显示文摘 | Taylor K G Gawthorpe R L Curt is C D | 2000 | Journal of Sedimentary Research2000，70，2： | 1 |
| 3 | 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (Updating the 2006 Guideline): a report of the American College of Cardiology Foundation/American Heart association Task Force on Pracitce Guidelines显示文摘 | Wann L S Curt is A B January C T | 2011 | Heart Rhythm2011，1，8： | 1 |
| 4 | reconstructive technique after endoscopic expanded endonasal approaches, vacular pediele nasoseptal flap 显示文摘 | Hadad G Bassagasteguy L Curt'an RI | 2006 | Laryngoscope2006，116，10： | 1 |
| 5 | An antibiotic substance active against certain phytopathogens显示文摘 | CURT L KEITT G W | 1948 | Phytopathology1948，38，： | 1 |
| 6 | Production and properties of Antimycin A from a new streptomyces isolate显示文摘 | LOCKWOOD J L CURT L KEITT G W | 1954 | Phytopathology1954，44，： | 1 |
| 7 | Sequestra- tion of carbon dioxide in coal with enhanced coal bed methane re- coverys : A review 显示文摘 | Curt M White Duane H Smith Kenneth L Jones | 2005 | Energy & Fuels2005，19，3： | 1 |
| 8 | Lymphocytic hypophysitis:differential diagnosis and effects ofhigh-dose pulse steroids,followed by azathioprine,on the pituitary mass andendocrine abnormalities-report of a case and literature review显示文摘 | CurtòL Torre ML Cotta OR | 2010 | Scientific World Journal2010，10，： | 1 |
| 9 | The Effect of Elevated Fetal Hemoglobin on Hemoglobin Ale Results Five Common Hemoglobin A1 c Methods Compared With the IFCC Reference Method 显示文摘 | Curt L Shawn M Jack D | 2008 | Am J Clin Pathol2008，129，： | 1 |
| 10 | Asymmetric transfer hydrogenation of ketones catalyzed by hydrophobic metal-amido complexes in aqueous mMicelles and vesicles显示文摘 | F Wang H Liu L Curt | 2005 | J Org Chem2005，70，： | 1 |
| 11 | The effect of elevated fetal hemoglobin on hemoglobin A1c results:five common hemoglobin A1c methods compared with the IFCC reference method显示文摘 | ROHLFING CURT L CONNOLLY SHAWN M ENGLAND JACK D | 2008 | Am J Clin Pathol2008，129，5： | 1 |
| 12 | A rapid method for extraction of cotton genomic DNA suitable for RFLP or PCR analysis显示文摘 | Andrew H Paterson Curt L Bruker Dure L | 1993 | Plant Molecular Biology Reporter1993，11，： | 1 |
| 13 | Mood disorders in eating disorder patients: Prevalence and chronology of ONSET 显示文摘 | Godart N Radon L Curt F | 2015 | J Affect Dis- ord2015，185，： | 1 |
| 14 | The effect of laser shock peening on the life and fallure mode of a cold pilger die显示文摘 | CURT A L SUNG T H MARK T S | 2008 | Journal of Materials Proeessing Technology2008，204，13： | 1 |
| 15 | An antibiotic substance active against certain phytopathogens显示文摘 | Curt L Keitt G W | 1948 | Phytopathology1948，38，： | 1 |
| 16 | Influence of sorghum wax,glycerin,and sorbitol on physical properties of soy protein isolate films显示文摘 | Kima K M David B Curts L | 2003 | JAOCS Vol2003，1，： | 1 |
| 17 | Differentiating between nonepileptic and epileptic seizures 显示文摘 | Orrin D Deana G Curt L | 2011 | Neurology2011，4，7： | 1 |
| 18 | Phylogenetic analysis of global hepatitis E virus sequences:genetic diversity, subtypes and zoonosis显示文摘 | LING L CHUNHUA L CURT H | 2006 | Virology2006，16，： | 1 |
| 19 | A rapid method for extraction of cotton (Gossypium-spp) genomic DNA suitable for RFLP and PCR analysis显示文摘 | PATERSON A H Curt L B Wendel J F | 1993 | Plant Mol Bio Reporter1993，11，2： | 1 |
| 20 | Thevalue of the Tip-Apex distance in predicting failure of fixation of peritrochanteric fractures of the hip显示文摘 | Baumgaertner MR Curt in S L indskog D | 1995 | J Bone Joint Surg (Am)1995，77，7： | 1 |
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