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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Copolymerization of Ethylene and Propyiene with Functionalized Vinyl Monomers by PalladiumII) Catalysts显示文摘 | Johnson L K Killian C M Arthur S D | | 0，，： | 4 |
| 3 | One stop shop:backbones trees for important phytopathogenic genera:Ⅰ(2014)显示文摘Many fungi are pathogenic on plants and cause significant damage in agriculture and forestry.They are also part of the natural ecosystem and may play a role in regulating plant numbers/density.Morphological identification and analysis of plant pathogenic fungi,while important,is often hampered by the scarcity of discriminatory taxonomic characters and the endophytic or inconspicuous nature of these fungi.Molecular(DNA sequence)data for plant pathogenic fungi have emerged as key information for diagnostic and classification studies,although hampered in part by non-standard laboratory practices and analytical methods.To facilitate current and future research,this study provides phylogenetic synopses for 25 groups of plant pathogenic fungi in the Ascomycota,Basidiomycota,Mucormycotina(Fungi),and Oomycota,using recent molecular data,up-to-date names,and the latest taxonomic insights.Lineagespecific laboratory protocols together with advice on their application,as well as general observations,are also provided.We hope to maintain updated backbone trees of these fungal lineages over time and to publish them jointly as new data emerge.Researchers of plant pathogenic fungi not covered by the present study are invited to join this future effort.Bipolaris,Botryosphaeriaceae,Botryosphaeria,Botrytis,Choanephora,Colletotrichum,Curvularia,Diaporthe,Diplodia,Dothiorella,Fusarium,Gilbertella,Lasiodiplodia,Mucor,Neofusicoccum,Pestalotiopsis,Phyllosticta,Phytophthora,Puccinia,Pyrenophora,Pythium,Rhizopus,Stagonosporopsis,Ustilago and Verticillium are dealt with in this paper. | Kevin D.Hyde R.Henrik Nilsson S.Aisyah Alias Hiran A.Ariyawansa Jaime E.Blair Lei Cai Arthur W.A.M.de Cock Asha J.Dissanayake Sally L.Glockling Ishani D.Goonasekara Michal Gorczak Matthias Hahn Ruvishika S.Jayawardena Jan A.L.van Kan Matthew H.Laurence C.AndréLévesque Xinghong Li Jian-Kui Liu Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda Frank N.Martin Eric H.C.McKenzie Alistair R.McTaggart Peter E.Mortimer Prakash V.R.Nair Julia Pawlowska Tara L.Rintoul Roger G.Shivas Christoffel F.J.Spies Brett A.Summerell Paul W.J.Taylor Razak B.Terhem Dhanushka Udayanga Niloofar Vaghefi Grit Walther Mateusz Wilk Marta Wrzosek Jian-Chu Xu JiYe Yan Nan Zhou | 2014 | Fungal Diversity2014，，4： | 3 |
| 4 | Where is the global in global mental health?A call for inclusive multicultural collaboration显示文摘To the editor:Common mental health disorders,like depression and anxiety,account for 45%of the global disease burden on youths aged 15-29.1 This challenge is particularly significant in low and middle-income countries(LMICs)where risk factors such as poverty,limited treatment options and stigma restrict access to care and exacerbate the burden and magnify the impact of mental disorders.23 Given these barriers,there is an urgent need for research dedicated to expanding mental healthcare for young people in LMICs. | Tom L Osborn Akash R Wasil John R Weisz Arthur Kleinman David M Ndetei | 2020 | General Psychiatry2020，33，6： | 2 |
| 5 | Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis显示文摘AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in vitro.METHODS:Helicobacter felis(H.felis)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 wk.After treatment,mice were analyzed for morphological changes and gastric acid content.Total RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of H.felis infection.Interestingly, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented H.felis-induced inflammation and atrophy.Compared to the uninfected controls,infected mice also had significantly decreased gastric acid.After eradication of H.felis with THIO treatment,gastric acidity was restored.Compared to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during infection.Despite elevated gastric acid levels, after eradication of H.felis with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was suppressed.Immunofluorescence revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during H.felis infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R activation.The stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin. | Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L Merchant | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | Ageing and Brugada syndrome: considerations and recommendations显示文摘Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patientwithBrugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditionsmay also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities. | Pieter G. Postema Hanno L Tan Arthur AM Wilde | 2013 | Journal of Geriatric Cardiology2013，10，1： | 2 |
| 8 | Dynamic capabilities and venture performance: the effects of venture capitalists 显示文摘 | Arthurs J D Busenitz L W | 2006 | Journal of Business Venturing2006，21，： | 1 |
| 9 | Solid phase microextraction with thermal desorption using fused silica optical fibers 显示文摘 | Pawliszyn J Arthur C L | 1990 | Anal Chem1990，62，： | 1 |
| 10 | Mortality in Pennsylvania 显示文摘 | Arthur L H Daniel captive elk ( Cervus 2007 19(3) : 334 P S Jenny S F elaphus) : 1998-2006 -337 | 2007 | J Vet Diagn Invest2007，，： | 1 |
| 11 | Forest floor microbial binmass across a northern hardwood successional sequence显示文摘 | Taylor L A Arthur M A Yanai R D | | 0，，03： | 1 |
| 12 | Solid-phase microextraction with thermal-desorption using fused-silica optical fibers显示文摘 | Arthur C L Pawliszyn J | 1990 | Analytical Chemistry1990，62，19： | 1 |
| 13 | Solid phase microextraction with thermal desorption using fused silica optical fibers 显示文摘 | ARTHUR C L PAWLISZYN J | 1990 | Anal Chem1990，62，： | 1 |
| 14 | The functional reserve of corneal endothelium显示文摘 | Shaw E L Rao G N Arthur E J | 1978 | Ophthalmology1978，85，6： | 1 |
| 15 | Solid phase raicroextraction with thermal desorption using fused silica optical fibers显示文摘 | ARTHUR L PAWLISZYN J | 1990 | Anal Chem1990，62，： | 1 |
| 16 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 17 | Thinking Outside the Black Box: The Importance of Context in Understanding the Impact of a Preoperative Education Nursing Intervention among Chi- nese Cardiac Patients显示文摘 | Guo P East L Arthur A | 2014 | Patient Educ Couns2014，95，3： | 1 |
| 18 | Efficacy Of rofecoxib,celecoxib,and acetaminophen in osteoarthritis of the knee:a randomized trial显示文摘 | Geba Gregory P Weaver Arthur L Plois Adam B | 2002 | The journal of American medical association2002，287，1： | 1 |
| 19 | Sofid phase microextracfion with thermal desorption using frsed silica optical fibers显示文摘 | Arthur C L Pawliszyn J | 1990 | J Anal Chem1990，62，19： | 1 |
| 20 | Geochemical and climatic effects of increased marine organic carbon burial at the Cenomanian/Turonian boundary显示文摘 | ARTHUR M A DEAN W PRATT L M | 1988 | Nature1988，335，： | 1 |
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