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| 1 | Targeting collagen expression in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is a leading cause of liver disease and liver-related deaths globally,particularly in developed nations.Liver fibrosis is a consequence of ALD and other chronic liver insults,which can progress to cirrhosis and hepatocellular carcinoma if left un-treated.Liver fibrosis is characterized by accumulation of excess extracellular matrix components,including typeⅠcollagen,which disrupts liver microcirculation and leads to injury.To date,there is no therapy for the treatment of liver fibrosis;thus treatments that either prevent the accumulation of typeⅠcollagen or hasten its degradation are desirable.The focus of this review is to examine the regulation of typeⅠcollagen in fibrogenic cells of the liver and to discuss current advances in therapeutics to eliminate excessive collagen deposition. | Kyle J Thompson Iain H McKillop Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 7 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 3 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 4 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 5 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 6 | Kinetics of the base decomposition of dodeeatungstophosphate(3-) in weakly alkaline solutions 显示文摘 | KYLE J H | 1983 | J Chem Soc Dalton Trans1983，105，12： | 1 |
| 7 | Rb-Sr dating of sphalerites from MVT ore deposits显示文摘 | Nakai S Halliday A N Kesler S E Jones H D Kyle J R Lane T E | 1993 | Geochimica et Cosmochimica Acta1993，57，： | 1 |
| 8 | Infection after total knee atthroplasty:aretrospective study of the treatment of eight-one infection显示文摘 | Segawa H Tsukayama DT Kyle RF | 1999 | J Bone Joint Surg(Am)1999，81，： | 1 |
| 9 | Soil nutrients influence spatial distributions of tropical tree species显示文摘 | Robert J James W D Kyle E H | 2007 | PNAS2007，104，3： | 1 |
| 10 | Multichannel Scanning Radiometer for Remote Sensing Cloud Physical Parameters显示文摘 | Curran R J Kyle H L Blaine L R | 1981 | Review of Scientific Instruments1981，52，： | 1 |
| 11 | Span:an energyefficient coordination algorithm for topology maintenance in ad hoc wireless networks显示文摘 | CHEN B KYLE J BALAKRISHNAN H | 2002 | ACM Wireless Networks Journal2002，8，5： | 1 |
| 12 | Rb-Sr dating of sphalerites from Mississippi Valley (MVT) ore deposits显示文摘 | Nakai S Halliday A N Kesler S E Jones H D Kyle J R and Lane T E | | 0，，： | 1 |
| 13 | Hybrid cartesian and orbit element feedback law for formation flying spacecraft显示文摘 | Schaub H Kyle T Alfriend | 2002 | Journal of Guidance Navigation and Control2002，25，2： | 1 |
| 14 | Insertion and deletion in a non - essential region of the nonstructural protein 2 ( nsp2 ) of Por- cine reproductive and respirator3' syndrome (PRRS) virus: effects on virulence and immunogenicity 显示文摘 | DAL Y K TROY J K KYLE H | 2009 | Virus Genes2009，38，1： | 1 |
| 15 | Carcinoid tumors 显示文摘 | Scott NP Kyle H Rebecca SS | 2008 | Oncol- ogist2008，13，12： | 1 |
| 16 | A prospective, randomized study of intramedullary nails inserted with and without reaming for the treatment of open and closed fractures of the tibial shaft显示文摘 | Finkemeier C G Schmidt A H Kyle R F | 2000 | J OrthopTrauma2000，14，3： | 1 |
| 17 | Stimulated shedding of vascular cell adhesion molecule 1 is mediated by'tumor necrosis factor-converting enzyme(Adam 17)显示文摘 | Kyle J Garton H Gough M | 2003 | J Biol Chemistry2003，278，37： | 1 |
| 18 | Analytical techniques for characterizing enzymathniic biofuel cells显示文摘 | MICHAEL J M ROBERT L A KYLE H S SHELLEY D M | 2009 | Anal Chem2009，81，23： | 1 |
| 19 | Mutual coupling between log-periodic antennas 显示文摘 | KYLE R H | 1970 | IEEE Transactions on Antennas Propagat1970，18，1： | 1 |
| 20 | Infection after total knee arthroplasty:aretrospective sutdy of the treatment of eight-one infection显示文摘 | Segawa H Tsukayama DT Kyle RF | 1999 | J Bone Joint Surg(Am)1999，81，： | 1 |
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