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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Clostridium paraputrificum septicemia and liver abscess显示文摘We report the first case of a healthy 23-year-old female who underwent an interventional radiology-guided embolization of a hepatic adenoma, which resulted in a gas forming hepatic liver abscess and septicemia by Clostridium paraputrificum. A retrospective review of Clostridial liver abscesses was performed using a Pub Med literature search, and we found 57 clostridial hepatic abscess cases. The two most commonly reported clostridial species are C. perfringens and C. septicum(64.9% and 17.5% respectively). C. perfringens cases carried a mortality of 67.6% with median survival of 11 h, and 70.2% of the C. perfringens cases experienced hemolysis. All C. septicum cases were found to have underlying liver malignancy at the time of the presentation with a mortality of only 30%. The remaining cases were caused by various Clostridium species, and this cohort's clinical course was significantly milder when compared to the above C. perfringens and C. septicum cohorts. | Yong K Kwon Faiqa A Cheema Bejon T Maneckshana Caroline Rochon Patricia A Sheiner | 2018 | World Journal of Hepatology2018，10，3： | 4 |
| 4 | Thermal and design sensitivity analyses for cooling system of injection mold, part 2: design sensitivity analysis显示文摘 | Park S J Kwon T H | 1998 | Journal of Manufacturing Science and Engineering1998，120，2： | 2 |
| 5 | Effects of thermal and chemical surface-flame interaction on flame quenching显示文摘 | KIM K T LEE D H KWON S | 2006 | Combust and Flame2006，146，： | 1 |
| 6 | Origin of a dolomite-related jade deposit at Chuncheon,Korea显示文摘 | Yui T F S T Kwon | 2002 | Economic Geology2002，97，3： | 1 |
| 7 | 显示文摘 | Kwon G S Okano T | 1996 | Advanced Drug Delivery Reviews1996，21，2： | 1 |
| 8 | Matter Overmind: When Specific Asset Investment Affects Calculative Trust in Supply Chain Partnership 显示文摘 | Suh T and Kwon G | 2006 | Industrial Marketing Management2006，35，2： | 1 |
| 9 | Detection of single nucleonucleotide insertion of BCL/ABL region in imatinib-resistance human myelogenous leukemia SR-1 Cells显示文摘 | Park T H Kwon K E Kim H J | 2005 | Exp Mol Med2005，37，5： | 1 |
| 10 | Catalytic properties of early transition metal nitrides and carbides:n-butane hydrogenolysis,dehydrogenation and isomerization显示文摘 | NEYLON M K CHOI S KWON H CURRY K E THOMPSON L T | 1999 | Appl Catal A1999，183，2： | 1 |
| 11 | Selegiline potentiates the effects of EGb761 in response to ischemic brain injury显示文摘 | Kwon YS Ann HS Nabeshima T | 2004 | Neurochem Int2004，45，1： | 1 |
| 12 | Synephrine-contai- ning dietary supplement precipitating apical ballooning syn- drome in a young female显示文摘 | CHUNG H KWON S W KIM T H | 2013 | Korean J Intern Med2013，28，3： | 1 |
| 13 | Energy-efficient Differentiated Directed Diffusion in Wireless Sensor Networks显示文摘 | Chen Min Kwon T Choi Y | | 0，，02： | 1 |
| 14 | Analysis of magnetization of mag- net in the rotor of line start permanent magnet motor 显示文摘 | LEE C K KWON B I KIM B T | 2003 | IEEE Transactions on Magnetic2003，39，3： | 1 |
| 15 | Long-termBehaviour of Square Concrete-Filled Steel Tubular Columnsunder Axial Service Loads 显示文摘 | KWON S H KIM T H KIM J K | 2007 | Magazine of ConcreteResearch2007，59，1： | 1 |
| 16 | Dynamic cross-linking of polymeric binders based on host-guest interactions for silicon anodes in lithium ion batteries显示文摘 | KWON T W JEONG Y K DENIZ E | 2015 | ACS Nano2015，9，11： | 1 |
| 17 | Mass-producible replication of highly hydrophobic surfaces from plant leaves 显示文摘 | Lee S M Kwon T H | 2006 | Nanotechnology2006，17，13： | 1 |
| 18 | Airway gene transfer using cationic emulsion as a mucosal gene carrier显示文摘 | Kim T W Chung H Kwon I C | 2005 | J Gene Med2005，7，6： | 1 |
| 19 | A cross-layer strategyfor energy-efficient reliable delivery in wireless sensornetworks显示文摘 | Kwon H Kim T H Choi S | 2006 | IEEE Trans on Wireless Commun2006，5，12： | 1 |
| 20 | Trehalose synthesis by sequential reactions of recombinant maltooligosyltrehalose synthase and maltooligosyltrehalose trehalohydrolase from Brevibacterium helvolum显示文摘 | Kim Y H Kwon T K Park S | 2000 | Appl Environm Microb2000，66，11： | 1 |
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