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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | Kinetics of monodisperse iron oxide nanocrystal formation by “heating-up” process 显示文摘 | Kwon S G Piao Y Z Park J | 2007 | J Am Chem Soc2007，129，12： | 1 |
| 4 | 显示文摘 | Kwon G S Okano T | 1996 | Advanced Drug Delivery Reviews1996，21，2： | 1 |
| 5 | Matter Overmind: When Specific Asset Investment Affects Calculative Trust in Supply Chain Partnership 显示文摘 | Suh T and Kwon G | 2006 | Industrial Marketing Management2006，35，2： | 1 |
| 6 | Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng显示文摘 | HAN J Y IN J G KWON Y S | 2010 | Phytochemistry2010，71，1： | 1 |
| 7 | Over expression of CD24:association with invasiveness in urothelial carcinoma of bladder显示文摘 | Choi Y L Lee S H Kwon G Y | 2007 | Arch Pathol Lab Med2007，131，2： | 1 |
| 8 | Microencapsulation of octadecane as a phase-change material by interfacial polymerization in an emulsion system 显示文摘 | Cho J S Kwon A Cho C G | 2002 | Collid Polym Sci2002，280，： | 1 |
| 9 | Regulation of ILlheta-mediated MUC2 gene in NCI-H292 human airway epithelial cells显示文摘 | Kim Y D Kwon E J Raque G H | 2000 | Biochem Biophys Res Commum2000，274，5： | 1 |
| 10 | Texture and cross-sectional microstructure of MgO films grown on silicon dioxide by electron-beam evaporation 显示文摘 | LEE J S RYU B G KWON H J | 1999 | Thin Solid Films1999，354，12： | 1 |
| 11 | High-performance, nano-structured LiMnPO4 synthesized via a polyol method 显示文摘 | WANG D Y BUQA H CROUZET M DEGHENGHI G DREZENT EXNAR I KWON N H MINERS J H POLETTO L GRATZEL M | 2009 | J Power Sources2009，189，1： | 1 |
| 12 | Structural evolution of a high Tc ferroelectric xBi (Znl/2Til/2 )O3 -( 1-x) PbTiO3 solid solution 显示文摘 | Zhang X D Kwon D Kim B G | 2008 | Applied Physics Letters2008，92，82： | 1 |
| 13 | Numerical simulation of MIL- S-901D heavy weight shock test of a double resiliently mounted main engine module 显示文摘 | Kwon J Lee S G Chung J H | 2005 | Journal of the Society of Naval Architects of Korea2005，42，5： | 1 |
| 14 | Horizontal equity in health care utilization evidence {tom three high-income Asian economies显示文摘 | Lu J R Leung G M Kwon S | 2007 | Social Science : Medicine2007，64，1： | 1 |
| 15 | Intra-arterial tiro- fiban infusion for thromboembolism during endovascular treatment of intracranial aneurysms显示文摘 | Kang H S Kwon B J Hoh H G | 2008 | Neurosurgery2008，63，2： | 1 |
| 16 | Time-frequency analy- sis of power quality disturbances via the Gabor-Wigner transform 显示文摘 | CHO S H JANG G KWON S H | 2010 | IEEE Transactions on Power Delivery2010，25，1： | 1 |
| 17 | Role of CD24 protein in predicting metastatic potential of uterine cervical squamous cell carcinoma in patients treated with radiotherapy 显示文摘 | Kwon GY Ha H Ahn G | 2007 | Int J Radial Oncol Biol Phys2007，69，4： | 1 |
| 18 | Full-rate cooperative com- munications with spatial diversity for half-duplex uplink relay channels 显示文摘 | KWON U CHOI C IM G | 2009 | IEEE Transactions on Wireless Communications2009，8，11： | 1 |
| 19 | Serum cystatin C is superior toserum creatinine as a marker of kidney function:a meta-analysis显示文摘 | Dharnidharka VR Kwon C Stevens G | 2002 | Am J Kidney Dis2002，40，2： | 1 |
| 20 | Ambient-dried silica aerogel doped with TiO2 powder for thermal insulation 显示文摘 | Kwon Y G Choi S Y Kang E S | 2000 | J Mater Sci2000，35，24： | 1 |
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