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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | 能谱CT在鉴别直径≤2 cm肺炎性结节与肺癌中的价值显示文摘目的 探讨能谱CT在鉴别直径≤2 cm的肺炎性结节和肺癌中的作用。方法 回顾性分析43例经病理证实的直径≤2 cm的孤立性肺结节(SPN)患者的资料,其中炎性结节13例,肺癌30例,均已行宝石能谱成像(GSI)扫描。测量2组结节动静脉期碘浓度(IC)、40 keV和90 keV对应的CT值,计算动静脉期标准化碘浓度(NIC),动静脉期标准化碘浓度差值(ICD),动静脉期能谱曲线斜率(40~90 keV)。对2组结节的上述指标进行独立样本t检验及受试者工作特征曲线(ROC曲线)分析。结果 炎性SPN动脉期NIC(0.12±0.02)<肺癌(0.17±0.03)(P<0.01),炎性SPN静脉期NIC(0.46±0.02)>肺癌(0.37±0.09)(P〈0.01)。炎性SPN ICD(0.34±0.03)>肺癌 (0.19±0.08)(P<0.01),NIC和ICD均有统计学意义(P<0.01)。两者动静脉期能谱曲线斜率(λHU)均无统计学意义(P>0.05)。鉴别两者的最佳定量参数值是ICD,其阈值0.29鉴别两者的敏感性和特异性分别为84.0%、100%。其次为动脉期NIC,其阈值0.15鉴别两者的敏感性和特异性分别为72.0%、100%。结论 能谱CT IC多参数分析对鉴别直径≤2 cm炎性SPN与肺癌的诊断价值较大,ICD和动脉期NIC具有较高的敏感度与特异度。 | 朱慧 郁义星 Sanjeev kumar PS 包捷 王希明 胡春洪 | 2018 | 实用放射学杂志2018，34，11： | 7 |
| 3 | Influence of micro- encapsulation method and peptide loading on formulation of poly(lactide-co-glycolide) insulin nanoparticles显示文摘 | Kumar PS Ramakrishna S Saini TR | 2006 | Pharmaz- ie2006，61，7： | 1 |
| 4 | Radioprotective effect of Panax ginseng on the phosphatases and lipid peroxidation level in testes of Swiss albino mice显示文摘 | Kumar M Sharma MK Saxena PS | 2003 | Biol Pharm Bull2003，26，3： | 1 |
| 5 | Mesenteric venous thrombosis显示文摘 | Kumar S Sarr MG Kamath PS | 2001 | N EnglJ Med2001，345，： | 1 |
| 6 | Expression of growth factors by airway epithelial cells in a model of chronic asthnm : regulation and relationship to subepithelial fibrosis显示文摘 | Kumar RK Herbert C Foster PS | 2004 | Clin Exp Allergy2004，34，4： | 1 |
| 7 | An improved murine model of asthma : selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen 显示文摘 | Temelkovski J Hogan SP Shepherd DP Foster PS Kumar RK | 1998 | Thorax1998，53，10： | 1 |
| 8 | Current concepts:mesenterie venous thrombosis显示文摘 | KUMAR S SARR MG KAMATH PS | 2001 | N Engl J Mad2001，345，： | 1 |
| 9 | Combined sequence and structure analysis of the fungal laccase family 显示文摘 | Kumar SV Phale PS Durani S | 2003 | Biotechnol- Bioeng2003，83，4： | 1 |
| 10 | New bacterial species associated with chronic periodontitis显示文摘 | Kumar PS Griffen AL Barton JA | 2003 | J Dent Res2003，82，5： | 1 |
| 11 | Mesenterie venous thrombosis显示文摘 | Kumar S Sarr MG Kamath PS | 2001 | N Engl J Med2001，345，23： | 1 |
| 12 | Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type 显示文摘 | Kumar A Seghal N Naidu PS | 2007 | Pharmacol Reports2007，59，： | 1 |
| 13 | The 'classical' ovalbumin chal- lenge model of asthma in mice 显示文摘 | Kumar RK Herbert C Foster PS | 2008 | Curr Drug Targets2008，9，6： | 1 |
| 14 | A clinical evalu-ation of orthodontic mini-implants as intraoral anchorage for the intrusion of maxillary anterior teeth显示文摘 | Saxena R Kumar PS Upadhyay M | | 0，，04： | 1 |
| 15 | Current concepts:mesenteric venous thrombosis显示文摘 | Kumar s Sarr MG Kamath PS | 2001 | N Engl J Med2001，345，： | 1 |
| 16 | New bacterial species associated with chronic periodontitis显示文摘 | Kumar PS Griffen AL Barton JA | 2003 | J Dent Res2003，82，5： | 1 |
| 17 | Recurrent Circuits in LayerⅡof Medial Entorhinal Cortex in a Model of Temporal Lobe Epilepsy显示文摘 | Kumar SS Jin X Buckmaster PS | 2007 | J Neurosci(S0270-6474)2007，27，6： | 1 |
| 18 | Etiology and Pathogenesis of Periodon-tal Disease显示文摘 | Tatakis DN Kumar PS | 2005 | Dent Clin North Am2005，49，3： | 1 |
| 19 | Distraction, com- pression and extension reduction of hasilar invagination and atlantoaxialdislocation: a novel pilot technique 显示文摘 | Chandra PS Kumar A Chauhan A | 2013 | Neuro- surgery2013，72，6： | 1 |
| 20 | A clinical e- valuation of orthodontic mini-implants as intraoral an- chorage for the intrusion of maxillary anterior teeth 显示文摘 | Saxena R Kumar PS Upadhyay M | 2010 | World J Orthod2010，11，4： | 1 |
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