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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | Surgical considerations for ‘intrinsic' brainstem gliomas: proposal of a modification in classification显示文摘 | Mehta VS Chandra PS Singh PK Garg A Rath GK | 2009 | 中国神经肿瘤杂志2009，7，3： | 9 |
| 3 | A case of coexisting cerebeUopontine anglemeningioma and schwannoma 显示文摘 | Chandra PS Hegde T | 2000 | Neurol India2000，48，： | 1 |
| 4 | Distraction, com- pression and extension reduction of hasilar invagination and atlantoaxialdislocation: a novel pilot technique 显示文摘 | Chandra PS Kumar A Chauhan A | 2013 | Neuro- surgery2013，72，6： | 1 |
| 5 | Images in neurooncology primary extra axial cerebellopontine angle ependy morea 显示文摘 | Kasliwal MK Chandra PS Sharma BS | 2007 | J Neu rooncol2007，83，： | 1 |
| 6 | Images in Neuro Oncology:Primary extraaxial cerebellopontine angle ependymoma显示文摘 | Kasliwal MK Chandra PS Sharma BS | 2007 | J Neurooncol2007，83，7： | 1 |
| 7 | HIV and mental health:An overview of research from India显示文摘 | Jayarajan N Chandra PS | 2010 | Indian J Psychiatry2010，52，1： | 1 |
| 8 | Quality of life in HIV subtype C infection among asymptomatic subjects and its association with CD4 counts andviral loads-a study from South India显示文摘 | Chandra PS Gandhi C Satishchandra P | 2006 | Qual Life Res2006，15，10： | 1 |
| 9 | Distraction, compression, and extension reduction of basilar invagination and atlantoaxial dislocation: a novel pilot technique 显示文摘 | Chandra PS Kumar A Chauhan A | 2013 | Neurosurgery2013，72，10： | 1 |
| 10 | Eosinophilic cystitis and its management显示文摘 | Teegavarapu PS Sahai A Chandra A | 2005 | Int J Clin Pract2005，59，3： | 1 |
| 11 | ESR spectroscopic study reveals higher free radical quenching potential in kodo millet (Paspalum scrobiculatum) compared to other millets显示文摘 | Hegde PS Chandra TS | 2005 | Food Chemistry2005，92，1： | 1 |
| 12 | Distraction, compres- sion, and extension reduction of basilar invagination and atlanto- axial dislocation: a novel pilot technique 显示文摘 | Chandra PS Kumar A Chauhan A | 2013 | Neurosurgery2013，72，6： | 1 |
| 13 | Intramedullary spinal epidermoid cyst显示文摘 | Chandra PS Manjari T Devi BI | 2000 | Neurol India2000，48，1： | 1 |
| 14 | Awake craniotomy versus surgery under general anaesthesia for resection of intrinsic lesions of eloquent cortex: aprospective randomised study 显示文摘 | Gupta DK Chandra PS Ojha BK | 2007 | Clin Neurol Neurosurg2007，109，4： | 1 |
| 15 | Eosinophilic cystitis and its management显示文摘 | Teegavarapu PS Sahai A Chandra A | | 0，，03： | 1 |
| 16 | Distraction, compres-sion, and extension reduction of basilar invagination and atlanto- axial dislocation:a novel pilot technique 显示文摘 | Chandra PS Kumar A Chanhan A | 2013 | Neurosurgery2013，72，6： | 1 |
| 17 | The severity of basilar invagination and atlantoaxial dislocation correlates with sagittal joint inclination, coronal joint inclination, and craniocervical tilt : a description of new indexes for the eraniovertebral junction 显示文摘 | Chandra PS Goyal N Chauhan A | 2014 | Neurosurgery2014，104，： | 1 |
| 18 | Role of concordance between ictal-subtraeted SPECT and PET in predicting long- term outcomes after epilepsy surgery显示文摘 | Chandra PS Vaghania G Bal CS | 2014 | Epilepsy Res2014，108，10： | 1 |
| 19 | Eosinophilic cystitis and itsmanagement显示文摘 | Teegavarapu PS Sahai A Chandra A | 2005 | Int J Clin Pract2005，59，： | 1 |
| 20 | Do Men and Women with HIV Differ in Their Quality of Life? A Study from South India 显示文摘 | Chandra PS Satyanarayana VA Satishchandra P | 2009 | AIDS Behav2009，13，1： | 1 |
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