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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | Role of live microbial feed supplements with reference to anaerobic fungi in ruminant productivity: A review显示文摘To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials(DFM) for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes(i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder) are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi(ARF) based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ARF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ARF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ARF as DFM. Therefore, DFM especially ARF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial properties to have a confirmed ‘generally regarded as safe' status for ruminants. | Anil K Puniya Abdelfattah Z M Salem Sanjay Kumar Sumit S Dagar Gareth W Griffith Monica Puniya Sreenivas R Ravella Nikhil Kumar Tejpal Dhewa Ravinder Kumar | 2015 | Journal of Integrative Agriculture2015，14，3： | 17 |
| 3 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 4 | Fabrication of Bi_2O_3/TiO_2nanocomposites and their applications to the degradation of pollutants in air and water under visible-light显示文摘A nanoheterojunction composite photocatalyst Bi2O3/TiO2working under visible-light(λ 420 nm) was prepared by combining two semiconductors Bi2O3 and TiO2 varying the Bi2O3/TiO2molar ratio. Maleic acid was employed as an organic binder to unite Bi2O3 and TiO2 nanoparticles. The SEM, TEM, XRD and diffuse reflectance spectra were utilized to characterize the prepared Bi2O3/TiO2nanoheterojunction. The nanocomposite exhibited unusual high photocatalytic activity in decomposing 2-propanol in gas phase and phenol in aqueous phase and, evolution of CO2 under visible light irradiation while the end members exhibited low photocatalytic activity. The composite was optimized to 5 mol% Bi2O3/TiO2. The remarkable high photocatalytic efficiency originates from the unique relative energy band position of Bi2O3 and TiO2 as well as the absorption of visible light by Bi2O3. | Ashok Kumar Chakraborty Md Emran Hossain Md Masudur Rhaman K M A Sobahan | 2014 | Journal of Environmental Sciences2014，26，2： | 7 |
| 5 | Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F.Muell显示文摘Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic cataract.Methods:Total phenol and flavonoid content of different fractions was determined.ARI activity of different fractions in rat lens was investigated in vitro.Results:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid content.The extract after further evaluation may be used in the treatment of diabetic cataract. | Patel DK Kumar R Kumar M Sairarn K Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 6 | Ordered Intermetallics显示文摘 | E P George M Yamaguchi K S Kumar C T Liu | 1994 | Annual Review of Materials Science1994，，： | 2 |
| 7 | MEGA4:Molecular Evolutionary Genetics Analysis(MEGA)software version 4.0显示文摘 | Tamura K Dudley J Nei M Kumar S | | 0，，： | 2 |
| 8 | Effect of the hydrophilic size on the structural phases of aqueous nonionic Gemini surfactant solutions显示文摘 | Nieh M P Kumar S K Fernando R H | 2004 | Langmuir2004，20，21： | 1 |
| 9 | MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment显示文摘 | Kumar S Tamura K Nei M | 2004 | Brief Bioinform2004，，5： | 1 |
| 10 | MEGA3:Integrated soft-ware for molecular evolutionary genetics analysis and se-quence alignment显示文摘 | KUMAR S TAMURA K NEI M | 2004 | Bioinformatics2004，5，： | 1 |
| 11 | MEGA3: an integrated software for molecular evolutionarygenetics analysis and sequence alignment 显示文摘 | KUMAR S TAMURA K NEI M | 2004 | Brief Bioinform2004，25，： | 1 |
| 12 | Review on TiC Reinforced Steel Composites 显示文摘 | Parashivamurthy K I KUMAR R K SEETHARAMU S HANDRASEKHARAIAH M N | 2001 | Journal of Materials Science2001，，36： | 1 |
| 13 | Computer Simulation of Transport Processes During Injection Mold-Filling and Optimization of the Molding Conditions显示文摘 | Kumar A Ghoshdastidar P S Muju M K | 2002 | Journal of Materials Processing Technology2002，120，3： | 1 |
| 14 | Chitosan WN-gamma-pDNA nanoparticle (CIN) therapy for allergic asthma 显示文摘 | Kumar M Kong X Behera A K | 2003 | Genet Vaccines Ther2003，1，1： | 1 |
| 15 | High level phytase pro- duction by Aspergillus niger NCIM 563 in solid state culture: re- sponse surface optimization, up -scaling, and its partial charac- terization 显示文摘 | Bhavsar K Kumar V R Khire J M | 2011 | J Ind Microbiol Biotechnol2011，38，9： | 1 |
| 16 | Integrated software for molec'ular evo- lutionary genetics analysis and sequence alignment 显示文摘 | Kumar S Tamura K Nei M | 2004 | Briefings in BioinfiJrnmtics2004，5，： | 1 |
| 17 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods 显示文摘 | Tamura K Peterson D Peterson N Stecher G Nei M Kumar S | 2011 | Molecular Biology and Evolution2011，28，10： | 1 |
| 18 | MEGA3 : integrated software for molecular evolutionary genetics analysis and sequence alignment 显示文摘 | KUMAR S TAMURA K NEI M | 2004 | Briefings in Bioinformaties2004，5，2： | 1 |
| 19 | Copper-cata-lyzed decarboxylative three-component reactions for the synthesis of imidazo[1,2-α]pyridines显示文摘 | PALANI T PARK K KUMAR M R | | 0，，26： | 1 |
| 20 | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India显示文摘 | Nikbakht M Malekzadeh K Kumar JA | | 0，，01： | 1 |
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