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| 1 | Anti-microbial principles of selected remedial plants from Southern India显示文摘Objective:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(E.coli),Pseudomonas aeruginosa(P.aeruginosa) and Staphylococcus aureus(S.aureus) bacterial strains.Results:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria studied.The EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative bacteria.The EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in E.coli and P.aeruginosa,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against P.aeruginosa and S.aureus.Three major compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf extractions.Among the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and 3-hexene-ol.Conclusions:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment. | Tirupathi Rao G Suresh Babu K J Ujwal Kumar Sujana P A Veerabhadr Raoa Sreedhar AS | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 5 |
| 2 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 3 | Optimizing the total skin-sparing mastectomy显示文摘 | Wijayanayagam A Kumar AS Foster RD | 2008 | Arch Surg2008，143，1： | 1 |
| 4 | Prevalence and risk factors of Metallo beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in burns and surgical wards in a tertiary care hospital显示文摘 | Kumar SH De AS Baveja SM | | 0，，： | 1 |
| 5 | Pericardiectomy for constrictive pericarditis:a clinical,echocardiographic,and hemodynamic evaluation of two surgical techniques显示文摘 | Chowdhury UK Subramaniam GK Kumar AS | 2006 | Ann Thorac Surg2006，81，2： | 1 |
| 6 | Anti-stress effects of cilnidipine and nimodipine in immobilization subjected mice显示文摘 | Kumar N Singh N Jaggi AS | 2012 | Physiol Behav2012，105，5： | 1 |
| 7 | A review on animal models for screening potential anti-stress agents显示文摘 | Jaggi AS Bhatia N Kumar N | | 0，，06： | 1 |
| 8 | Mitral valve replacement with and without chordal preservation in a rheumatic population: serial eehocardiographic assessment of left ventricular size and function显示文摘 | Chowdhury UK Kumar AS Airan B | 2005 | Ann Thorac Surg2005，79，6： | 1 |
| 9 | A comparative study of a spray dryer with rotary disc Atomizer and pressure noz- zle using computational fluid dynamic simulations显示文摘 | HUANG LX KUMAR K MUJUMDARC AS | 2006 | Chem Eng Process2006，45，6： | 1 |
| 10 | Renal denervation therapy for resistant hypertension: a clinical update显示文摘 | Ram CV Kumar AS | 2014 | J Hum Hypertens2014，28，12： | 1 |
| 11 | Chordal preservation during mitral valve replacement:basis,techniques and results 显示文摘 | Talwar S Jayanthkumar HV Kumar AS | 2005 | Ind J Thorac Cardiovasc Surg2005，21，： | 1 |
| 12 | Abrin induced oxidative stress mediated DNA damage in human leukemic cells and its reversal by N-acetylcysteine显示文摘 | Bhaskar AS Deb U Kumar O | 2008 | Toxicol In Vitro2008，22，8： | 1 |
| 13 | Mitral valve replacement with and without chordal preservation in a rheumatic population: serial echocardiographic assessment of left ventricular size and function显示文摘 | Chowdhury UK Kumar AS Airan B | 2005 | Ann Thorac Surg2005，79，： | 1 |
| 14 | Optimizing the total skin-sparing mastectomy显示文摘 | Wijayanayagam A Kumar AS Foster RD | 2008 | Arch Surg2008，143，1： | 1 |
| 15 | Laparoscopy in colorectal surgery显示文摘 | Kumar AS Lee SW | 2013 | Surg Clin North Am2013，93，1： | 1 |
| 16 | Complications of transanal endoscopic microsurgery are rare and minor: a single institution's analysis and comparison to existing data 显示文摘 | Kumar AS Coralic J Kelleher DC | 2013 | Dis Colon Rectum2013，56，： | 1 |
| 17 | Estrogen receptor-nega- tive breast cancer is less likely to arise among lipophilic statin users显示文摘 | KUMAR AS BENZ CC SHIM V | 2008 | Cancer Epidemiol Biomarkers Prey2008，17，5： | 1 |
| 18 | Bacteria exopolysacchar- ides-a perception显示文摘 | Kumar AS Mody K Jha B | 2008 | Basic Microbiol2008，47，： | 1 |
| 19 | Search for anti-inflammatory agents显示文摘 | Kapoor VK Chawla AS Kumar M | 1993 | Indian Drugs1993，，30： | 1 |
| 20 | Control o f Cooperating MobileManipulators 显示文摘 | Thom as G Sugar Vi jay Kumar | 2002 | IEEE Transaction on Robotics andAutomation2002，8，1： | 1 |
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