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| 1 | Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations显示文摘Constipation and fecal impaction are frequent and distressing complaints in pediatric gastroenterology. Especially in neurologically handicapped children, treatment of severe forms of slow-transit constipation (STC) can be difficult. In the majority of cases, STC is of unknown etiology. However, in recent years, there is growing evidence that interstitial cells of Cajal (ICCs), which serve as electrical pacemakers and generate spontaneous electrical slow waves in the gastrointestinal tract, might play an important role in the pathophysiology of STC. It remains unclear whether morphological ICC alterations seen in affected patients are based on congenital developmental anomalies, or whether they are a consequence of long-term constipation with secondary damage of the gastrointestinal nervous system. To the best of our knowledge, we present the first case of a patient with histological alterations in ICC morphology who displayed multiple alterations of c-kit at the level of mRNA. The protein encoded by c-kit is the receptor tyrosine kinase Kit (CD117), which is crucial for development and function of ICCs. Therefore, these findings provide a new explanation for congenital alterations of ICC development that result in gastrointestinal motility disorders. | Christian Breuer Jun Oh Gerhard J Molderings Michael Schemann Birgit Kuch Ertan Mayatepek Rüdiger Adam | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 2 | Characterisation of particulates and carcinogenic polycyclic aromatic hydrocarbons in wintertime wood-fired heating in residential areas显示文摘 | Md. Aynul Bari Guenter Baumbach Johannes Brodbeck Michael Struschka Bertram Kuch Werner Dreher Guenter Scheffknecht | 2010 | Atmospheric Environment2010，，40： | 1 |
| 3 | Investigations of the reduction and re-oxidation kinetics of iron (III ) oxide scales formed in waters 显示文摘 | Kuch A | 1988 | Corros Sci1988，30，3： | 1 |
| 4 | Induced Fe and Mn magnetic moments in Co-FeMn bilayers on Cu(001) 显示文摘 | Offi F Kuch W Chelaru L I Fukumoto K Kotsugi M Kirschner J | 2003 | Physical Review B2003，67，09： | 1 |
| 5 | Influence of exchange bias coupling on the single-crystal- line FeMn ultrathin film 显示文摘 | Wang J Kuch W Chelaru L I Offi F Kotsugi M | 2005 | Applied Physics Letters2005，86，12： | 1 |
| 6 | Presenting symptoms of myocardial infarction predict short- and long-term mortality: The MONICA/KORA Myocardial Infarction Registry显示文摘 | Inge Kirchberger Margit Heier Bernhard Kuch Wolfgang von Scheidt Christa Meisinger | 2012 | American Heart Journal2012，，6： | 1 |
| 7 | Efficient synthesis of the blood-coagulation inhibitor hirudin in the filamentous fungus Acremonium chrysogenum显示文摘 | RADZIO R KUCH U | 1997 | Appl Micro biotechnol1997，48，： | 1 |
| 8 | Heavy metals, PCDD/F and PCB in sewage sludge samples from two wastewater treatment facilities in Rio de Janeiro State,Brazil显示文摘 | Marcia S P Kuch B | 2005 | Chemosphere2005，60，： | 1 |
| 9 | Novel conopeptides of the I-superfamily occur in several clades of cone snails显示文摘 | KAUFERSTEIN S HUYS I KUCH U | 2004 | Toxicon2004，44，5： | 1 |
| 10 | Mortality and func- tional morbidity after use of PALS/APLS by community phy- sicians显示文摘 | Carcillo JA Kuch BA Han YY | 2009 | Pediatrics2009，124，2： | 1 |
| 11 | Investigations of the reduction and re-oxidation kinetics of iron (Ⅲ) oxide scales formed in waters显示文摘 | Kuch A | 1988 | Corrosion Science1988，30，3： | 1 |
| 12 | Determination of endocrine-disrupting phenolic compounds and estrogens in surface and drinking water by HRGC-(NCI)-MS in the picogram per liter range显示文摘 | Kuch H M Ballschrniter K | 2001 | Environmental Science & Technology2001，35，15： | 1 |
| 13 | Indexation of left ventricular mass in adult with a novel approximation for fat-free mass显示文摘 | Kuch B Gneiting B Doring A | 2001 | J Hy-pertns2001，19，1： | 1 |
| 14 | Determination of endocrine- disrupting phenolic compounds and estrogens in surface and drinking water by HRGC-(NCI) -MS in the picogram per liter range 显示文摘 | KUCH H M BALLSCHMITTER K | 2001 | Environ Sci Technol2001，35，15： | 1 |
| 15 | Implantation a new accommodative posterior chamber intraocular lens显示文摘 | Kuch le M | 2002 | Refract Surg2002，18，： | 1 |
| 16 | General anesthesia For interven- tional neuroradiology: propofol versus isoflurane 显示文摘 | Munte S Munte TF Kuche H | 2001 | J ClinAnesth2001，65，45： | 1 |
| 17 | Behavior and design of single anchors under tensile load in uncracked concrete显示文摘 | COOK R A KUCHS J FUCHS R C | 1998 | Structural Journal1998，95，1： | 1 |
| 18 | Heavy metals, PCDD/F and PCB in sewage sludge samples from two wastewater treatment facilities in Rio de Janeiro State, Brazil显示文摘 | de Souza Pereira M Kuch B | 2005 | Chemosphere2005，60，： | 1 |
| 19 | Mortality andfunctional morbidity after use of PALS/APLS by community physicians显示文摘 | Carcillo JA Kuch BA Han YY | 2009 | Pediatrics2009，124，2： | 1 |
| 20 | Association between homocysteine and coagulation factor-α crossectional study in two population of central Europe显示文摘 | KUCH B BOBAK M FOBKER M | 2001 | Thromb Res2001，103，3： | 1 |
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