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| 1 | Impact of the gut microbiota on rodent models of human disease显示文摘Traditionally bacteria have been considered as either pathogens,commensals or symbionts.The mammal gut harbors 1014 organisms dispersed on approximately1000 different species.Today,diagnostics,in contrast to previous cultivation techniques,allow the identification of close to 100%of bacterial species.This has revealed that a range of animal models within different research areas,such as diabetes,obesity,cancer,allergy,behavior and colitis,are affected by their gut microbiota.Correlation studies may for some diseases show correlation between gut microbiota composition and disease parameters higher than 70%.Some disease phenotypes may be transferred when recolonizing germ free mice.The mechanistic aspects are not clear,but some examples on how gut bacteria stimulate receptors,metabolism,and immune responses are discussed.A more deeper understanding of the impact of microbiota has its origin in the overall composition of the microbiota and in some newly recognized species,such as Akkermansia muciniphila,Segmented filamentous bacteria and Faecalibacterium prausnitzii,which seem to have an impact on more or less severe disease in specific models.Thus,the impact of the microbiota on animal models is of a magnitude that cannot be ignored in future research.Therefore,either models with specific microbiota must be developed,or the microbiota must be characterized in individual studies and incorporated into data evaluation. | Axel Kornerup Hansen Camilla Hartmann Friis Hansen Lukasz Krych Dennis Sandris Nielsen | 2014 | World Journal of Gastroenterology2014，20，47： | 4 |
| 2 | Treatment of OA of the knee in the middle-aged athlete:the role of arthroscopy显示文摘 | Krych AJ Bert JM Levy BA | | 0，，01： | 1 |
| 3 | Isolated arthroscopic ro- tator interval closure for shoulder instability显示文摘 | Krych AJ Shildle MK Baran S | 2013 | Arthrosc Tech2013，3538，： | 1 |
| 4 | Supplementation of a lacto-fermented rapeseed-seaweed blend promotes gut microbial-and gut immune-modulation in weaner piglets显示文摘Background:The direct use of medical zinc oxide in feed will be abandoned after 2022 in Europe,leaving an urgent need for substitutes to prevent post-weaning disorders.Results:This study investigated the effect of using rapeseed-seaweed blend(rapeseed meal added two brown macroalgae species Ascophylum nodosum and Saccharina latissima)fermented by lactobacilli(FRS)as feed ingredients in piglet weaning.From d 28 of life to d 85,the piglets were fed one of three different feeding regimens(n=230 each)with inclusion of 0%,2.5% and 5% FRS.In this period,no significant difference of piglet performance was found among the three groups.From a subset of piglets(n=10 from each treatment),blood samples for hematology,biochemistry and immunoglobulin analysis,colon digesta for microbiome analysis,and jejunum and colon tissues for histopathological analyses were collected.The piglets fed with 2.5% FRS manifested alleviated intraepithelial and stromal lymphocytes infiltration in the gut,enhanced colon mucosa barrier relative to the 0% FRS group.The colon microbiota composition was determined using V3 and V1-V8 region 16S rRNA gene amplicon sequencing by Illumina NextSeq and Oxford Nanopore MinION,respectively.The two amplicon sequencing strategies showed high consistency between the detected bacteria.Both sequencing strategies indicated that inclusion of FRS reshaped the colon microbiome of weaned piglets with increased Shannon diversity.Prevotella stercorea was verified by both methods to be more abundant in the piglets supplied with FRS feed,and its abundance was positively correlated with colonic mucosa thickness but negatively correlated with blood concentrations of leucocytes and IgG.Conclusions:FRS supplementation relieved the gut lymphocyte infiltration of the weaned piglets,improved the colon mucosa barrier with altered microbiota composition.Increasing the dietary inclusion of FRS from 2.5% to 5% did not lead to further improvements. | Yan Hui Paulina Tamez-Hidalgo Tomasz Cieplak Gizaw Dabessa Satessa Witold Kot Søren Kjærulff Mette Olaf Nielsen Dennis Sandris Nielsen Lukasz Krych | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 1 |
| 5 | Staged protocol for initial management of the dislocated knee显示文摘 | Levy BA Krych AJ Shah JP | | 0，，12： | 1 |
| 6 | Substitution of two amino acids confers C3b binding to the C4b binding site of CRI(CD35) analysis based on ligand binding by chimpanzeeerythrocytecomplementreceptor显示文摘 | SUBRAMANIAN V B CLEMENZA L KRYCH M | 1996 | J Immunol1996，157，3： | 1 |
| 7 | Characterization of the gut microbiota in leptin deficient obese mice – Correlation to inflammatory and diabetic parameters显示文摘 | M. Ellekilde L. Krych C.H.F. Hansen M.R. Hufeldt K. Dahl L.H. Hansen S.J. S?rensen F.K. Vogensen D.S. Nielsen A.K. Hansen | 2014 | Research in Veterinary Science2014，，： | 1 |
| 8 | Acute renal failure显示文摘 | KRYCH M | 2005 | Internisf (Berl)2005，46，1： | 1 |
| 9 | Total hip arthroplasty with shortening subtrochanteric osteotomy in Growe type IV devel-opmental dysplasia显示文摘 | Krych A J Howard JI Trousdale RT | 2009 | J Bone Joint Surg Am2009，91，9： | 1 |
| 10 | Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells显示文摘 | Camilla H. F. Hansen Thomas L. Holm ?ukasz Krych Lars Andresen Dennis S. Nielsen Ida Rune Axel K. Hansen S?ren Skov | 2012 | Eur J Immunol2012，，2： | 1 |
| 11 | Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells显示文摘 | Hansen C H F Holm T L Krych L | 2013 | European Journal of Immunology2013，43，2： | 1 |
| 12 | Acute renal failure显示文摘 | Krych M | 2005 | Internist (Berl)2005，46，1： | 1 |
| 13 | Allograft versus autograft in posterior cruciate ligament reconstruction:an evidence-based systematic review显示文摘 | Hudgens JL Gillette BP Krych AJ | 2013 | J Knee Surg2013，26，2： | 1 |
| 14 | long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas显示文摘 | Wendtner CM Rahman SA Krych M Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts | 2002 | Clin Oncol2002，20，14： | 1 |
| 15 | Structure-function relationships of complement receptor type l显示文摘 | Krych Goldberg M Atkinson JP | 2001 | Immunol Rev2001，180，1： | 1 |
| 16 | Gut microbiota composition is correlated to grid floor induced stress and behavior in the B ALB/c mouse显示文摘 | BANGSGAARD BENDTSEN K M KRYCH L SORENSEN D B | 2012 | Plos one2012，7，10： | 1 |
| 17 | Acute renal failure 显示文摘 | Krych M | 2005 | Internist ( Berl )2005，46，1： | 1 |
| 18 | Total hip arthroplasty with shortening subtrochanteric osteotomy in Crowe type - IV devel- opmental dysplasia 显示文摘 | Krych A J Howard JL Trousdale RT | 2009 | J Bone Joint Surg Am2009，91，： | 1 |
| 19 | Total hip arthroplasty with shortening subtrochanteric osteotomy in Crowe type-IV developmental dysplasia:surgical technique显示文摘 | Krych AJ Howard JL Trousdale RT | 2010 | J Bone Joint Surg Am2010，92，1： | 1 |
| 20 | Synergy between two active sites of human complement receptor type 1 (CD35) in complement regulation: implications for the structure of the classical pathway C3 convertase and generation of more potent inhibitors显示文摘 | Krych Goldberg M Hauhart RE Porzukowiak T | 2005 | J Immunol2005，175，： | 1 |
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