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| 1 | Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review显示文摘Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease(IBD).Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels,long standing disease,and frequent steroid exposures;as a result,it is well established that vitamin D supplementation in this population is important.There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD.The active form of vitamin D,1,25(OH)D3,acts on T cells to promote T helper(Th)2/regulatory T responses over Th1/Th17 responses;suppresses dendritic cell inflammatory activity;induces antibacterial activity;and regulates cytokine production in favor of an antiinflammatory response.Murine and human IBD studies support a therapeutic role of vitamin D in IBD.Risk factors for vitamin D deficiency in this population include decreased sunlight exposure,disease duration,smoking,and genetics.Vitamin D normalization is associated with reduced risk of relapse,reduced risk of IBD-related surgeries,and improvement in quality of life.Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes.However,further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects,and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission,as well as maintaining this improvement in patients’disease states. | Krista M Reich Richard N Fedorak Karen Madsen Karen I Kroeker | 2014 | World Journal of Gastroenterology2014，20，17： | 34 |
| 2 | Distance management of inflammatory bowel disease:Systematic review and meta-analysis显示文摘AIM:To review the effectiveness of distance management methods in the management of adult inflammatory bowel disease(IBD)patients.METHODS:A systematic review and meta-analysis of randomized controlled trials comparing distance management and standard clinic follow-up in the management of adult IBD patients.Distance management intervention was defined as any remote management method in which there is a patient self-management component whereby the patient interacts remotely via a self-guided management program,electronic interface,or self-directs open access to clinic follow up.The search strategy included electronic databases(Medline,PubMed,CINAHL,The Cochrane Central Register of Controlled Trials,EMBASE,KTPlus,Web of Science,and SCOPUS),conference proceedings,and internet search for web publications.The primary outcome was the mean difference in quality of life,and the secondary outcomes included mean difference in relapse rate,clinic visit rate,and hospital admission rate.Study selection,data extraction,and risk of bias assessment were completed by two independent reviewers.RESULTS:The search strategy identified a total of4061 articles,but only 6 randomized controlled trials met the inclusion and exclusion criteria for the systematic review and meta-analysis.Three trials involved telemanagement,and three trials involved directed patient self-management and open access clinics.The total sample size was 1463 patients.There was a trend towards improved quality of life in distance management patients with an end IBDQ quality of life score being 7.28(95%CI:-3.25-17.81)points higher than standard clinic follow-up.There was a significant decrease in the clinic visit rate among distance management patients mean difference-1.08(95%CI:-1.60--0.55),but no significant change in relapse rate or hospital admission rate.CONCLUSION:Distance management of IBD significantly decreases clinic visit utilization,but does not significantly affect relapse rates or hospital admission rates. | Vivian W Huang Krista M Reich Richard N Fedorak | 2014 | World Journal of Gastroenterology2014，20，3： | 9 |
| 3 | Evaluation of Sur- face Lignin on Cellulose Fibers with XPS显示文摘 | LEENA S J CAMPBELL J M KRISTA K | 1999 | Applied Surface Science1999，14，： | 1 |
| 4 | Noninvasive measurements of actively-induced change in muscle metabolism显示文摘 | KEVIN K M HITROOMI K KRISTA V | 1995 | J Bio1995，24，： | 1 |
| 5 | Ester syn- thesis and hydrolysis in an aqueous environment, and strain specific changes during malolactic fermentation in wine with Oenococcus oeni显示文摘 | Krista M Sumby Vladimir Jiranek Paul R Grbin | 2013 | Food Chemistry2013，141，3： | 1 |
| 6 | Chemicals from agricultural biomass: chemoenzymatic approach for pro- duction of vinylphenols and polyvinylphenols from phe- nolic acids 显示文摘 | Hannes L Stephan G Krista M | 2013 | Green Process Synth2013，，2： | 1 |
| 7 | Mono- kine induced by interferon gamma and IFN-response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients 显示文摘 | CLAR1CE A KRISTA E M DANIELY G | 2006 | Microbes and Infection2006，8，1： | 1 |
| 8 | Effect of nitrate and nitrite on sulfide production by two ther- mophilic, sulfate - reducing enrichments from an oil field in the North Sea显示文摘 | Krista M Kaster Alexander Grigoriyan Gary Jenneman Gerrit Voor- douw | 2007 | Environmental Biotechnology2007，75，： | 1 |
| 9 | Determination of olanzapine in a Postmortem case显示文摘 | Amanda J J Krista M S Heather N R | 1998 | Journal of Analytical Toxicology1998，22，7： | 1 |
| 10 | Lactose modifications enhance its drug performance in the novel multiple dose Taifun DPI 显示文摘 | Pa ivi H Vesa- Pekka L Krista M Eero S Tapio L Petteri P Kristiina J | 2002 | European Journal of Pharmaceutical Sciences2002，16，： | 1 |
| 11 | New insights into protein intake and progression of renal disease显示文摘 | Krista Lentine Elizabeth M Wrone | 2004 | Current Opinion in Nephrology and Hypertension2004，，3： | 1 |
| 12 | Mininally invasive vein surgery显示文摘 | Steve M Elias MD Krista L | 2004 | The Mount Sinai Journal of Medicine2004，71，1： | 1 |
| 13 | Glucocorticoid effects on changes in bone mineral density and cortical structure in childhood nephrotic syndrome显示文摘 | Anne Tsampalieros Pooja Gupta Michelle R Denburg Justine Shults Babette S Zemel Sogol Mostoufi‐Moab Rachel J Wetzsteon Rita M Herskovitz Krista M Whitehead Mary B Leonard | 2013 | J Bone Miner Res2013，，3： | 1 |
| 14 | CO2 adsorption in Y and X zeolites modified by alkali metal cation exchange 显示文摘 | Krista S W Morgan B A Douglas L M | 2006 | Microporous and Mesoporous Materials2006，91，13： | 1 |
| 15 | Ester synthesis and hydrolysis in an aqueous environment, and strainspecific changes during malolactic fermentation in wine with Oenococcusoeni显示文摘 | Sumby Krista M Jiranek Vladimir Grbin Paul R | 2013 | Food Chemistry2013，108，141： | 1 |
| 16 | Micro- bial modulation of aromatic esters in wine: Current knowl- edge and future prospects显示文摘 | Krista M Sumby Paul R Grbin Vladimir Jiranek | 2010 | Food Chemistry2010，，： | 1 |
| 17 | Characterization of cultured-independent and-dependent microbial communities in a high-temperature offshore chalk petroleum reservoir显示文摘 | Kaster Krista M Bonaunet Kristin Berland Harala | 2009 | Antonie Van Leeuwenhoek2009，96，4： | 1 |
| 18 | In Vivo Imaging of Endogenous Pancreatic [Beta]-Cell Mass in Healthy and Type 1 Diabetic Subjects Using ^sup 18^F-Fluoropropyl-Dihydrotetrabenazine and PET显示文摘 | Normandin Marc D Petersen Kitt F Ding Yu-Shin Lin Shu-Fei Naik Sarita Fowles Krista Skovronsky Daniel M Herold Kevan C McCarthy Timothy J Calle Roberto A Carson Richard E Treadway Judith L Cline Gary W | 2012 | EN2012，，6： | 1 |
| 19 | Characterization of culture independent and dependent microbial communities in a high-temperature off shore chalk petroleum reservoir显示文摘 | Krista K M Bonaunet K Berland H | 2009 | Antonie Van Leeuwenhoek2009，96，4： | 1 |
| 20 | Implications of new research and technologies for malolactic fermentation in wine显示文摘 | Krista M S Paul R G Vladimir J | 2014 | Applied Microbiology and Biotechnology2014，98，19： | 1 |
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