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| 1 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 2 | Abdominal obesity adversely affects bone mass in children显示文摘AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance(HOMA-IR) was calculated using the formula(Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA; Hologic QDR 4500, Waltham, MA, United Kingdom). RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC), whereas HOMA-IR was associated positively with whole body BMC.CONCLUSION Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance. | Sowmya Krishnan Michael P Anderson David A Fields Madhusmita Misra | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 3 |
| 3 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 4 | Gastric hyperplastic polyps causing upper gastrointestinal hemorrhage in a young adult显示文摘Here, we report a case of a young man who presented with a significant upper gastrointestinal bleed treated by endoscopic removal of multiple hyperplastic polyps. Gastric hyperplastic polyps are a relatively uncommon cause of overt gastrointestinal bleeding. While most hyperplastic gastric polyps are asymptomatic, they may present with abdominal pain, iron def iciency anemia or gastric outlet obstruction. These polyps are associated with conditions such as Helicobacter pylori gastritis and atrophic autoimmune gastritis, which predispose the epithelium to chronic inf lammation and epithelial repair.The patient presented to Northwestern Memorial Hospital in July 2011. The polyps were resected by clip-assisted snare polypectomy. Histopathologic assessment of the resected polyps demonstrated multiple, nonulcerative hyperplastic polyps measuring 1.3-1.8 cm in size, without evidence of dysplasia or malignancy. This case describes a young adult patient with multiple, large gastric polyps causing overt gastrointestinal bleeding. This is a rare presentation in a young individual, as these polyps are typically identifi ed in patients older than 60 years of age and less commonly, pediatric populations. | Brian J Secemsky Kenika R Robinson Kumar Krishnan Kristina A Matkowskyj Barbara H Jung | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 5 | Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats显示文摘 | Kirkin V Steffen A | 2003 | Cancer Res2003，63，3： | 1 |
| 6 | Coordinating Contracts for Decentralized Supply Chains with Retailer Promotional Effort显示文摘 | Krishnan H Kapuscinski R Butz D A | 2004 | Management Science2004，50，1： | 1 |
| 7 | Respiratory physiologic changes in pregnancy 显示文摘 | Wise RA Polito A J Krishnan V | 2006 | Immunol Allergy Clin North Am2006，26，： | 1 |
| 8 | CT arteriography and venography Jn puIsatiIe tinnitus:prelimfnary results显示文摘 | Krishnan A N1attox DE Fountain AJ et aI | 2006 | AJNR Am J NeuroradioI2006，27，8： | 1 |
| 9 | Effect of coherent to incoherent structural transition on magnetic anisotropy in Co/Pt muhilayers 显示文摘 | Chowdhury P Kulkkarni P D Krishnan M Barshilia H C Sagdeo A Rai S K Lodha G S Rao D V S | 2012 | Journal of Applied Physics2012，112，02： | 1 |
| 10 | Annexin II: a mediator of the plasmirdplas- minogen activator system 显示文摘 | Hajjar K A Krishnan S | 1999 | Trends in cardiovascular medicine1999，9，5： | 1 |
| 11 | Trade-offs associated with axillary lymph node dissection with breast irradiation versus breast irradiation alone in patients with a positive sentinel node in relation to the risk of non-sentinel node involvement: implications of ACOSOG Z0011 显示文摘 | Krishnan MS Recht A Bellon JR | 2013 | Breast Cancer Res Treat2013，138，1： | 1 |
| 12 | Ajoene inhibition of platelet aggregation:Possible mediation by a hemoprotein显示文摘 | Jamaluddin MP Krishnan LK Thomas A | 1988 | Biochemical and Biophysical Research Communications1988，153，1： | 1 |
| 13 | Alkylation of phenol with tertiary butyl alcohol over zeolite显示文摘 | Krishnan A V OjhaK Pradhan N C | 2002 | Org Proc Res Dev2002，6，： | 1 |
| 14 | Colloidalnanocrystal shape and size control:the case of cobalt显示文摘 | PUNTES V F KRISHNAN K M ALIVISATOS A P | 2001 | Science2001，291，： | 1 |
| 15 | Differential in vivo and in vitro expression of vascular endothelial growth factor VEGF-C and VEG F-D in tumor and its relationship to lymphatic metastaisis in immunocompetent rats显示文摘 | Krishnan J KirKin V Steffen A | 2003 | Cancer Res2003，63，3： | 1 |
| 16 | Robust anisotropic Gauasian fitting for volumetric characterization of puhnonary nodules in muhisllce CT 显示文摘 | Okada K Comaniciu D Krishnan A | 2005 | IEEE Trans on Medical Imaging2005，24，3： | 1 |
| 17 | Immunocytochemical localization of wheat prolamins in the lumen of the rough endoplasmic reticulum显示文摘 | Krishnan H B White J A Pueppke S G | 1991 | Cananian Journal of Botany1991，39，： | 1 |
| 18 | On Evaluating In- formation Revelation Policies in Procurement Auctions:A Markov Decision Process Approach 显示文摘 | GREENWALD A KANNAN K KRISHNAN'R | 2010 | Information Systems Research2010，21，1： | 1 |
| 19 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 20 | Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity显示文摘 | Park S B Lin C S Krishnan A V | 2011 | PlosOne2011，6，18： | 1 |
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