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| 1 | How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) for staging of gastric cancers. METHODS: Only EUS studies confirmed by surgery were selected. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Articles were searched in Medline, Pubmed, Ovid journals, Cumulative index for nursing & allied health literature, International pharmaceutical abstracts, old Medline, Medline nonindexed citations, and Cochrane control trial registry. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. 2 × 2 tables were constructed with the data extracted from each study. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specifi city, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fi xed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran's Q test based upon inverse variance weights. RESULTS: Initial search identified 1620 reference articles and of these, 376 relevant articles were selected and reviewed. Twenty-two studies (n = 1896) which met the inclusion criteria were included in this analysis. Pooled sensitivity of T1 was 88.1% (95% CI: 84.5-91.1) and T2 was 82.3% (95% CI: 78.2-86.0). For T3, pooled sensitivity was 89.7% (95% CI: 87.1-92.0). T4 hada pooled sensitivity of 99.2% (95% CI: 97.1-99.9). For nodal staging, the pooled sensitivity for N1 was 58.2% (95% CI: 53.5-62.8) and N2 was 64.9% (95% CI: 60.8-68.8). Pooled sensitivity to diagnose distant metastasis was 73.2% (95% CI: 63.2-81.7). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS results are more accurate with advanced disease than early disease. If EUS diagnoses advanced disease, such as T4 disease, the patient is 500 times more likely to have true anatomic stage of T4 disease. | Srinivas Reddy Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Mainor R Antillon Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，25： | 33 |
| 2 | Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review显示文摘AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy. | Srinivas R Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Jamal A Ibdah Daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 3 | Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts显示文摘Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions(PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early detection represents an opportunity for intervention to prevent the progression to pancreatic adenocarcinoma. Our aim for this review is to systematically review the current literature on confocal endomicroscopy and molecular biomarkers in the evaluation of PCLs. Confocal laser endomicroscopy is a novel technology that allows for real-time in vivo microscopic imaging with multiple clinical trials identifying characteristic endomicroscopy findings of various pancreatic cystic lesions. DNA-based molecular markers have also emerged as another diagnostic modality as the pattern of genetic alternations present in cyst fluid can provide both diagnostic and prognostic data. We propose that both techniques can be utilized to improve patient outcomes. | Feng Li Ahmad Malli Zobeida Cruz-Monserrate Darwin L Conwell Somashekar G Krishna | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 2 |
| 4 | Unreamed interlocking nailing in open fractures of tibia显示文摘 | Joshi D Ahmed A Krishna L | 2004 | J Orthop Surg2004，12，3： | 1 |
| 5 | Surface and Coatings Technology 显示文摘 | Sundararajan G Rama Krishna L | 2003 | 167:2692003，167，： | 1 |
| 6 | Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation显示文摘 | Seibenhener M L Babu J R Geetha T Wong H C Krishna N R Wooten M W | | 0，，18： | 1 |
| 7 | The tribological performance of ultra-hard ceramic composite coatings obtained through microarc oxidation显示文摘 | Rama Krishna L Somaraju K R C Sundararajan G | 2003 | Surf Coat Technol2003，，： | 1 |
| 8 | Mechanisms underlying the formation of thick alumina coating through the MAO coating technology显示文摘 | Sundararajan G Krishna L R | 2003 | Surface and Coating Technology2003，167，： | 1 |
| 9 | Effect of micro arc oxidation coatings on eorrosion resistance of 6061-al alloy 显示文摘 | WASEKAR N P JYOTHIRMAYI A KRISHNA L R | 2008 | Journal of Materials Engineering and Performance2008，17，5： | 1 |
| 10 | A neural network inverse modeling approach for the design of spiral inductor显示文摘 | Dr K Sri Rama Krishna J Lakshmi Narayana Dr L Pratap Reddy | 2011 | International Journal of Computer Science&Engineering Technology2011，2，3： | 1 |
| 11 | Mechanisms underlying the formation of thick alumina coatings through the MAO coating technology 显示文摘 | SUNDARARAJAN G RAMA KRISHNA L | 2003 | Surf Coat Technol2003，167，： | 1 |
| 12 | Method development and validation for optimized separation of benzo (a) pyrene - quinone isomers using liquid chromatography - mass spectrometry and chemometric response surface methodology 显示文摘 | Aidee Gonzalez Krishna L Foster | 2007 | Journal of Chromatography A2007，1167，： | 1 |
| 13 | Mechanisms underlying the formation of thick aluminum coatings through the MAO coating technology 显示文摘 | SUNDDARAJAN G RAMA KRISHNA L | 2003 | Surface and Coatings Technology2003，167，： | 1 |
| 14 | Influence of Microarc Oxidation and Hard Anodizing on Plain Fatigue and Fretting Fatigue Behaviour of Al-Mg-Si Alloy显示文摘 | RAJASEKARAN B GANESH SUNDARA RAMAN S RAMA KRISHNA L | 2008 | Surface and Coatings Technology2008，202，8： | 1 |
| 15 | Thermo-mechanical finite element analysis of a rail wheel显示文摘 | Amanan L Krishna K R Sriraman R | 1999 | International Journal of Mechanical Sciences1999，41，： | 1 |
| 16 | The Tribological Performance of Uitra-hard Ceramic Composite Coating Obtained Through Micro arc Oxidation显示文摘 | KRISHNA L Rama SOMARAJU K R C SUNDARARA JAN G | 2003 | Surface and Coating Technology2003，，16： | 1 |
| 17 | ANN modles for coplanar strip line analysis and synthesis显示文摘 | Lakshmi J Narayana Dr K Sri Rama Krishna Dr L Pratap Reddy | 2008 | International Journal of Computer Science and Network Security2008，8，10： | 1 |
| 18 | Strong red emission in Eu3+/Bi3+ ions codoped CaWO4 phophors for white light-emitting diode and field-emission display applications显示文摘 | Du P Bharat L Krishna Yu J S | 2015 | Journal of Alloys and Compounds2015，633，： | 1 |
| 19 | The tribological performance of ultra-hard ceramic composite coatings obtained through microarc oxidation显示文摘 | Krishna L R Somaraju K R C Sundararajan G | 2003 | Surf Coat Techn2003，，30： | 1 |
| 20 | Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen - induced late - phase airway obstruction in asthma显示文摘 | Krishna MT Chauhan A Little L | 2001 | J Allergy Clin Immunol2001，107，6： | 1 |
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