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| 1 | Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening:A meta-analysis显示文摘AIM:To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2(faecal M2-PK) test for colorectal cancer(CRC) screening based on the currently available studies.METHODS:A literature search in PubMed and Embase was conducted using the following search terms:fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS:Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3%;the specificity was 95.2%.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test(gFOBT).Faecal M2PK demonstrated a sensitivity of 81.1%,whereas the gFOBT detected only 36.9% of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma(n = 554),with the following sensitivities:adenoma < 1 cm in diameter:25%;adenoma > 1 cm:44%;adenoma of unspecified diameter:51%.In a direct comparison with gFOBT of adenoma > 1 cm in diameter,47% tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27%.CONCLUSION:We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity. | Carolin Tonus Markus Sellinger Konrad Koss Gero Neupert | 2012 | World Journal of Gastroenterology2012，18，30： | 17 |
| 2 | 一种先进的±550 kV高压直流GIS及其潜在应用显示文摘全球能源市场的变化如电能生产和用电负荷区域分布的变化、陆上及海上风能发电的增长促使高压直流输电和变电技术的进一步应用,变电站、换流站以及不同传输介质之间的转换站采用紧凑的直流气体绝缘开关(DC GIS)技术方案越来越多地成为最佳选择。与交流系统相比,直流GIS的绝缘系统有一些特殊性,如绝缘子表面电荷积聚现象、电导率对电荷积聚的影响、温度对电导率的影响、这些因素对电场强度分布的影响等。基于这些考虑,优化了绝缘系统的场强分布,设计了用于电压等级达±550 kV、额定电流高达5000 A的直流GIS的新型环氧树脂绝缘子和隔离开关等必备功能模块。此外还讨论了引入电场均匀化材料(FGM)来进一步改善电场分布的可行性。具有典型功能模块配置的直流GIS通过了专门的介电性能试验、热电性能和机械性能试验,以及国际大电网会议CIGRE推荐的绝缘系统试验等。这项技术将用于德国计划中的南北直流输电线路的变电站。 | 李德军 刘志民 KOSSE M KUSCHEL M JUHRE K | 2020 | 高压电器2020，56，6： | 5 |
| 3 | Overview of development, design, testing and application of compact gas-insulated DC systems up to ±550 kV显示文摘The development of high-voltage direct current gas-insulated switchgear assemblies(DC GIS)of rated voltages up to±550 kV has been completed.DC GIS provide a compact technical solution with a high functional density,optimized for projects with limited space as in offshore HVDC converter platforms,onshore HVDC converter stations and transition stations between different transmission media.Up to now,no standards for testing of gas-insulated DC systems are available,although pre-standardization work is in progress within CIGRE.Some tests can be performed as required in AC GIS standards.Special aspects of DC voltage stress,like the electric field distribution of insulators influenced by the accumulation of electrical charge carriers and the operation-related inhomogeneous temperature distribution,must be considered by additional electric and thermoelectric tests.For DC GIS,the experience of long-term performance is limited today.Although ageing is expected to be of lower importance,tests are recommended.This contribution summarizes the physical and technical background to design and develop compact DC switchgear assemblies using gas-insulated technology.It explains the developed modules of the substation and gives an overview of the performed tests.Furthermore,it provides an insight in the on-going standardization activities and describes applications in converter and transition stations,showing its space-saving characteristics. | Maria Kosse Dejun Li Karsten Juhre Mark Kuschel | 2019 | Global Energy Interconnection2019，2，6： | 2 |
| 4 | Tumors of minor salivary origin,a clinicopathologic study of 492 cases显示文摘 | Spiro R H Koss L G Hajdu S I | 1973 | Cancer1973，31，1： | 1 |
| 5 | The organizing pneumonias:an update and review显示文摘 | Schesinger C Koss MN | 2005 | Curr Opin Pulm Med2005，11，： | 1 |
| 6 | Dynamic holographic optical tweezers显示文摘 | CurtisJ E Koss B A Grier D G | 2002 | Optics Communications2002，207，1： | 1 |
| 7 | Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat显示文摘 | Campese VM Kogosov E Koss M | | 0，，： | 1 |
| 8 | Solitary pulmonary papillomas in Adults:a clinicopathologic an in situ hybridization study of 14 cases combined with 27 cases in the literature显示文摘 | Flieder D B Koss M N Nicholson A | 1998 | Am J Surg Pathol1998，22，11： | 1 |
| 9 | Amphotericin B-resistant Aspergillus flavus infection successfully treated with caspofungin, a novel antifungal agent显示文摘 | Bagheri B Zeana C | 2002 | J Am Acad Dermatol2002，46，6： | 1 |
| 10 | CD4 + and CD8 + regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome显示文摘 | Zheng S G Wang J H Koss M N | 2004 | J Immunol2004，172，3： | 1 |
| 11 | Primary non-Hodgkin's lymphoma of lung: A study of 161 patients 显示文摘 | Koss MN Hochholzer L Nichols PW | 1983 | Hum Pahtol1983，14，19： | 1 |
| 12 | Pulmonary blastomas显示文摘 | Koss MN Hochholzer L O'Leary T | 1991 | Cancer1991，67，9： | 1 |
| 13 | 查看详情显示文摘 | Haid J Koss U | | 0，，： | 1 |
| 14 | Pulmonary sarcoidosis显示文摘 | Lynch JP Ma YL Koss MN | 2007 | Semin Respir Crit Care Med2007，28，1： | 1 |
| 15 | Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes 显示文摘 | Plueinska K Crouch B Koss D | 2014 | J Neurosci2014，34，10： | 1 |
| 16 | Faecal dimerie M2 pyruvate kinase in colorectal cancer and polyps correlates with turnout staging and surgical intervention显示文摘 | Koss K Maxton D Jankowski JA | 2008 | Colorectal Dis2008，10，3： | 1 |
| 17 | Design of hammer mills for optimum performance显示文摘 | Kosse V Mathew J | 2001 | Proceeding of the Institution of Mechanical Engineers2001，215，： | 1 |
| 18 | The Papanicolaou test for cervical cancer detection -a triumph and tragedy显示文摘 | Koss LG | 1989 | JAMA1989，261，： | 1 |
| 19 | Primary non-Hodgkin's lymphoma and pseudolymphoma of lung:a study of 161 patients显示文摘 | Koss MN Hochholzer L Nichols PW | 1983 | Human pathology1983，14，： | 1 |
| 20 | Necropsy findings in acquired immunodeficiency syndrome:A comparison of premortem di agnoses with postmortem findings显示文摘 | Hui AN Koss MN Meyer PR | 1984 | Hum Pathol1984，15，7： | 1 |
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