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| 1 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kipt 显示文摘 | Medema RH Kops GJ Bos JL | 2000 | Nature2000，404，6779： | 1 |
| 3 | Ambulatory monitoring of physical activity and symptoms in fibromgalgia and chronic fatigve syndreome 显示文摘 | Kop U J Lylea A Kristen A | 2005 | Arthnitis and Rhevmatism2005，52，： | 1 |
| 4 | The challenges to connectivist learning on open online networks: Learning experiences during a massive online course 显示文摘 | Kop Rita | 2011 | The International Review of Research in Open and Distance Learning2011，，12： | 1 |
| 5 | The challenges to connectivist learning on open online networks: Learning experiences during a massive online course 显示文摘 | Kop Rita | 2011 | The International Review of Research in Open and Distance Learning2011，12，3： | 1 |
| 6 | The challenges to connectivist learning on open online networks: Learning experiences during a massive open online course 显示文摘 | Kop R | 2011 | The International Review of Research in Open and Distributed Learning2011，12，3： | 1 |
| 7 | On the road to canc- er: aneuploidy and the mitotic checkpoint 显示文摘 | Kops GJ Weaver BA Cleveland DW | 2005 | Nat Rev Cancer2005，5，： | 1 |
| 8 | Anthocyanins and chlorogenie acid eopigmentation influence on the color of strawber- ry and ehokeberry juices 显示文摘 | WILSKA-JESZKA J KOP ZUCHOWSKA A | 1996 | Food Res Teeh1996，203，： | 1 |
| 9 | The human EGF-TM7 family: a postgenomic view 显示文摘 | Kwakkenbos M J Kop EN Stacey M | 2004 | Immunogenetics2004，55，10： | 1 |
| 10 | Effects of acute mental stress and exercise on T wave alterans显示文摘 | Kop WJ Krantz DS Nearing BD | 2004 | Circulation2004，109，15： | 1 |
| 11 | Direct control of the Forkhead transcription factor AFX by protein kinase B显示文摘 | Kops G J de Ruiter ND de Vries-Smits AM | 1999 | Nature1999，398，6728： | 1 |
| 12 | ZW10 links mitotic checkpoint signaling to the structure kinetochare显示文摘 | Kops G J Kim Y Weaver BA | 2005 | Cell Biol2005，169，1： | 1 |
| 13 | Depression in heart failure biobehavioral mechanisms显示文摘 | Kop WJ Synowski SJ Gottlieb SS | 2011 | Heart Fail Clin2011，7，1： | 1 |
| 14 | Fluidization and sedimentation of carrier material in a pilot-scale airlift internal-loop reactor for wastewater treatment 显示文摘 | Cai J Th J Nieuwstad Kop J H | 1992 | Water Science Technology1992，26，911： | 1 |
| 15 | Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress显示文摘 | Kops GJ Dansen TB Polderman PE | 2002 | Nature2002，419，6904： | 1 |
| 16 | 显示文摘 | Jankova K Chen X Kops J | 1998 | Macromolecules 19981998，538，： | 1 |
| 17 | Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘 | Van Der Kop D A M Ruys G Dees D | 2003 | Physiolo- gia Plantarum2003，117，2： | 1 |
| 18 | Forkhead transcription factor FOXO3a protects quiescent cells from oxidativestress显示文摘 | Kops G J Dansen TB Polderman PE | 2002 | Nature2002，419，6904： | 1 |
| 19 | Chondrogenesis of mesenchymal stem ceils in an osteochondral environment is mediated by the suhehondrai bone 显示文摘 | de Vries -van Melle ML Narcisi R Kops N | 2014 | Tissue Eng Part A2014，20，12： | 1 |
| 20 | A pedagogy of abundance or a pedagogy to support human beings? Par- ticipant support on massive open online courses显示文摘 | Rita Kop Helene Foumier John Sui Fa Mak | 2011 | Inter- national Review of Research in Open and Distance Learn- ings2011(7) :74-932011，2011，7： | 1 |
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