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285篇 您的检索式：作者名="Kohn P"

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	题名	作者	年代	出处	被引量
1	Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.	Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton	2015	Bone Research2015，3，3：	8
2	Acoustic Emis- sion During Fatigue of Ti-6A1-4V: Incipient Fatigue Crack Detection Limits and Generalized Data Analy- sis Methodology 显示文摘	Kohn D H Dueheyne P Awerbuch J	1992	Journal of Materials Science1992，27，31：	1
3	Discovery of potent LPA2 (EDG4) antagonists as potential an- ticancer agents 显示文摘	BECK H P KOHN T RUBENSTEIN S	2008	Bioorganic & Medicinal Chemistry Letters2008，18，3：	1
4	Inhomogeneous electron gas显示文摘	HOHENBERG P KOHN W	1964	Phys Rev B1964，136，：	1
5	Diamond MEMS-a New Emerging Technology显示文摘	Kohn E Gluche P Adamschik M	1999	Diamond & Related Materials1999，8，25：	1
6	Shaping the Australian crust over the last 300 million years:Insights from fission track thermotectonic and denudation studies of key terranes显示文摘	Kohn B P Gleadow A J W Brown R W	2002	Australian Journal of Earth Sciences2002，49，：	1
7	Phys Rev B显示文摘	Hohenberg P Kohn W	1964	36:8641964，36，：	1
8	Inhomogeneous electron GaS显示文摘	Hohenberg P Kohn W	1964	Phys Rev B1964，136，3：	1
9	Guidelines for surgical treatment of gastroesophageal reflux disease 显示文摘	Stefanidis D Hope W W Kohn G P	2010	Surg Endos2010，24，11：	1
10	Phase separation in the melt and confined crystallization as the key to well-ordered microphase separated donor-acceptor block copolymers显示文摘	Lohwasser R H Gupta G Kohn P	2013	Macromolecules2013，46，11：	1
11	Inhomogeneous electron gas 显示文摘	Hohenberg P Kohn W	1964	Physical Review1964，136，3：	1
12	Inhomogeneous electron gas显示文摘	HOHENBERG P KOHN W	1964	Phys Rev:B1964，136，3：	1
13	Inhomogeneous Electron Gas显示文摘	HOHENBERG P KOHN W	1964	Physical Review1964，136，3：	1
14	Antimic: a database of antimicrobial sequences显示文摘	Brahmachary M Krishnan S P Kohn	2004	Nucleic Acids Res2004，32，：	1
15	Inhomogeneous electron gas显示文摘	Hohenberg P Kohn W	1964	Phys Rev1964，136，：	1
16	Industrial Diamond Substitutes Ⅰ:Physical and X-ray Study of Hafnium Carbide显示文摘	COTTER P G KOHN J A		0，，：	1
17	long-term landscape evolution of the northparkes region of the lachlan fold belt, Australia:constraints from fission track and paleomagnetic data显示文摘	Gibson D L Kohn B P	2000	Journal of Geology2000，148，1：	1
18	Inhomogencous electron gas显示文摘	Hohenberg P Kohn W	1964	Plays Rev1964，136，3：	1
19	Inhomogeneous Electron Gas显示文摘	Hohenberg P Kohn W	1964	Physical Review 131964，136，：	1
20	Information hiding-A survey显示文摘	Fabien A P Petitcolas Ross J Anderson Markus G Kohn	1999	Proceedings of the IEEE1999，87，7：	1

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