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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Posterior lingual lidocaine: A novel method to improve tolerance in upper gastrointestinal endoscopy显示文摘AIM: To evaluate the effect of posterior lingual lidocaine swab on patient tolerance to esophagogastro-duodenoscopy, the ease of performance of the procedure, and to determine if such use will reduce the need for intravenous sedation. METHODS: Eighty patients undergoing diagnostic esophagogastroduodenoscopy in a tertiary care medical center were randomized to either lidocaine swab or spray. Intravenous meperidine and midazolam were given as needed during the procedure. RESULTS: Patients in the lidocaine swab group (SWG) tolerated the procedure better than those in the spray group (SPG) with a median tolerability score of 2 (1, 4) compared to 4 (2, 5) (P < 0.01). The endoscopists encountered less diffi culty performing the proceduresin the SWG with lower median difficulty scores of 1 (1, 5) compared to 4 (1, 5) in the SPG (P < 0.01). In addition, the need for intravenous sedation was also lower in the SWG compared to the SPG with fewer patients requiring intravenous sedation (13/40 patients vs 38/40 patients, respectively, P < 0.01). The patients in the SWG were more satisfi ed with the mode of local anesthesia they received as compared to the SPG. In addition, the endoscopists were happier with the use of lidocaine swab. CONCLUSION: The use of a posterior lingual lidocaine swab in esophagogastroduodenoscopy improves patient comfort and tolerance and endoscopist satisfaction and decreases the need for intravenous sedation. | Assaad M Soweid Shadi R Yaghi Faek R Jamali Abdallah A Kobeissy Michella E Mallat Rola Hussein Chakib M Ayoub | 2011 | World Journal of Gastroenterology2011，17，47： | 2 |
| 3 | SARS-CoV-2 involvement in central nervous system tissue damage显示文摘As the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to spread globally,it became evident that the SARS-CoV-2 virus infects multiple organs including the brain.Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes.Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood,several theories have been suggested including direct and indirect pathways induced by the virus.One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route.Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells.Nevertheless,the indirect mechanisms,including blood-clotting abnormalities and prolonged activation of the immune system,can result in further tissue and organ damages seen during the course of the disease.This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients. | Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah HFarran Abdullah Shaito Esber SSaba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 4 | Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE- capillary liquid chromatography-tandem mass spectrometry 显示文摘 | Haskins WE Kobeissy FH Wolper RA | 2005 | J Neurotrauma2005，22，6： | 1 |
| 5 | Rapid discovery ofputative protein biomarkers of traumatic brain injury bySDS-PAGE-capillary liquid chromatography-tandem massspectrometry显示文摘 | Haskins WE Kobeissy FH Wolper RA | 2005 | J Neurotrauma2005，22，6： | 1 |
| 6 | Rapid discovery of putative protein biomarkers of traumatic brain injury by SDSPAGE-capillary liquid chromatography-tandem mass spectrometry显示文摘 | Haskins WE Kobeissy FH Wolper RA | 2005 | J Neurotrauma2005，22，6： | 1 |
| 7 | Novel dif- ferential neuroproteomics analysis of traumatic brain injury in rats显示文摘 | KOBEISSY FH OTTENS AK ZHANG Z | 2006 | Mol Cell Proteomics2006，5，10： | 1 |
| 8 | Mi- crobial cell components induced tolerance to flagellin- stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells 显示文摘 | LI N QUIDGLEY M C KOBEISSY F H | 2012 | Cytokine2012，60，3： | 1 |
| 9 | A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation显示文摘 | A. Soweid A. Kobeissy F. Jamali M. El-Tarchichi A. Skoury H. Abdul-Baki L. El-Zahabi A. El-Sayyed K. Barada A. Sharara F. Mourad A. Arabi | 2010 | Endoscopy2010，，08： | 1 |
| 10 | Impact of the Community Reinvestment Act on New Business Start-Ups and Economic Growth in Local Markets显示文摘 | Kobeissi Nada | 2009 | Journal of Small Business Management2009，，4： | 1 |
| 11 | Performance enhancing,non- prescription dose of Ritalin: a comparison with amphetamines and cocaine显示文摘 | Svetlov S I Kobeissy F H Gold M S | 2007 | J Addict Dis2007，26，4： | 1 |
| 12 | Assessing neuro-systemic & behavioral components in the pathophysiology of blast-related brain injury显示文摘 | Kobeissy F Mondello S Tamer N | 2013 | Front Neurol2013，，4： | 1 |
| 13 | Reproductive tract in- fections (RTIs)among married non-pregnant women liv- ing in a low-income suburb of Beirut,Lebanon 显示文摘 | Ramia S Kobeissi L E1 KF | 2012 | J In- fect Dev Ctries2012，6，9： | 1 |
| 14 | A randomized single- blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation 显示文摘 | Soweid AM Kobeissy AA Jamali FR | 2010 | Endoscopy2010，42，8： | 1 |
| 15 | Combining biochemi- cal and imaging markers to improve diagnosis and char- acterization of mild traumatic brain injury in the acute setting:results from a pilot study 显示文摘 | Kou Z Gattu R Kobeissy F | 2013 | PLoS 0ne2013，8，80： | 1 |
| 16 | Methamphetamine- and trauma- induced brain injuries: comparative cellular and molecular neurobiological substrates 显示文摘 | Gold MS Kobeissy FH Wang KK | 2009 | Biol Psychiatry2009，66，2： | 1 |
| 17 | CYP2E1 and NQO1 genotypes and bladder cancer risk in a Lebanese population显示文摘 | Basma HA Kobeissi LHjJabbour ME | 2013 | Int J Mol Epidemiol Genet2013，4，4： | 1 |
| 18 | Suggested insulin regimens for patients with type 1 diabetes mellitus who wish to fast during the month of Ramadan显示文摘 | Kobeissy A Zantout MS Azar ST | 2008 | Clin Ther2008，30，8： | 1 |
| 19 | Novel differential neuroproteomics analysis of traumatic brain injury in rats 显示文摘 | Kobeissy FH Ottens AK Zhang Z | 2006 | Mol Cell Proteomics2006，10，5： | 1 |
| 20 | Assessment of serum UCH-L1 and GFAP in acute stroke patients显示文摘 | Ren C Kobeissy F Alawieh A | 2016 | Sci Rep2016，6，24： | 1 |
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