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| 1 | 氟胺氰菊酯的定性定量分析显示文摘氟胺氰菊酯是一种用于蜜蜂的高效杀螨剂。从 2 0 %商品氟胺氰菊酯粉剂中通过硅胶柱层析分离得到了 96 .6 %的纯品并用FTIR和GC MS进行定性定量测定。采用GC MS定量分析的方法 ,氟胺氰菊酯的浓度在 0 .0 5~ 10mg L范围为线性响应 ,最低检测极限为 0 .0 1mg L。采用R(- )N 3 ,5 二硝基苯甲酰 苯基甘氨酸和长链烃的硅胶微粒手性柱 ,可成功地分离氟胺氰菊酯的二种旋光异构体 ,它们在商品氟胺氰菊酯中的比例近似为 | 冯建跃 陈关喜 吴清洲 刘清 徐秀珠 胡耿源 Pavol Kois Alexander Perjessy | 2001 | 分析化学2001，29，11： | 7 |
| 2 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 3 | MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis显示文摘 | Keun Hur Yuji Toiyama Masanobu Takahashi Francesc Balaguer Takeshi Nagasaka Junichi Koike Hiromichi Hemmi Minoru Koi C Richard Boland Ajay Goel | 2013 | Gut2013，，9： | 6 |
| 4 | Repeated cupping manipulation temporary decreases natural killer lymphocyte frequency, activity and cytotoxicity显示文摘OBJECTIVE: Elevated natural killer lymphocyte cytotoxicity(NKc) has been linked with reproductive problems in women. Here we evaluate the potential benefit of cupping therapy(CT) in reproductionrelated immune responses.METHODS: This was a pilot clinical study. Participants were he althy fe male volunteers(n = 23) with elevated NKc, and received repeated CT 3 times over 5 d(inner pressure 40–50 kPa, 40 min; 12–1 5 cups). Lymphocyte subsets, NKc and NK lymphocyte activity(NKa) were measured in blood on day 0(initial levels, before the first treatment) and days 3, 10 and 17 after the last CT treatment, using the K562-stimulated CD69 expression assay.RESULTS: As a result of CT manipulations NKa was reduced on days 3 and 10, and NK percentage was reduced on day 10. NKc was most sensitive to CT treatment, resulting in their decreased counts at 3, 10 and 17 d post CT. CT treatment decreased NKc in the majority of individuals(87%), but the magnitude of the effect was variable. Out of 23 subjects 9(39.1%) had a 2–3 fold decrease of NKc on days 3, 10 and 17; 11(47.8%) started to show a decrease in NKc later, or more quickly returned to base levels; and only 3(13%) subjects displayed no effect of CT on NKc. Expectedly, no changes in T-cell subsets(CD3CD4, CD3CD8, HLADR, CD158a) were observed after CT.CONCLUSION: CT decreased NK cell numbers, their activity and cytotoxicity. Low cost, safety, noninvasive nature and ease of administration make CT a promising approach for NKc down-regulation. | Boris V.Dons' koi Viktor P.C hernyshov Dariia V.Osypchuk Sergiy M.Baksheev | 2016 | Journal of Integrative Medicine2016，14，3： | 6 |
| 5 | 氯雷他定的结构分析显示文摘氯雷他定是一种高效抗过敏药。采用质谱、红外光谱、核磁共振氢谱、碳谱以及1 H检测的异核多量子相干相关谱等技术 。 | 赵菁 冯建跃 陈关喜 刘清 胡耿源 Pavol Kois Alexander Perjessy | 2003 | 分析化学2003，31，3： | 2 |
| 6 | 基于图像分割的驾驶员分心行为识别研究显示文摘针对驾驶员分心行为对交通安全产生隐患的问题,提出一种结合图像分割与卷积神经网络的驾驶员分心行为检测方法。该方法通过使用图像分割处理后的驾驶员不同分心行为的图像对卷积网络结构模型进行训练,来减轻背景噪声的影响,以提高模型的识别性能。试验中使用未经分割的图像与经过前景分割后图像分别训练卷积神经网络模型,用分割后图像训练的模型识别的准确率达到了93.84%,高于使用原图像训练的模型。试验结果表明,结合图像分割和深度学习的驾驶员分心行为检测方法对驾驶员的分心行为有较好的检测效果。 | 叶绿 陈铖 Sugianto Sugianto Chido Natasha Muponda Agordzo George Kofi Koi David Ernest | 2020 | 浙江科技学院学报2020，32，3： | 2 |
| 7 | Probing of the spliceoseme with site-specifically derivatized 5' splice site RNA oligonucleotides显示文摘 | LEVY T KOIS P | 1998 | RNA1998，4，： | 1 |
| 8 | Viral in-fection of the trophoblast:time to take a serious look at its rolein abnormal implantation and placentation?显示文摘 | Arechavaleta-Velasco F Koi H Strauss J F | 2002 | Reprod Im-munol2002，55，1： | 1 |
| 9 | The Effects of Employee Satisfaction, Organizational Citi- zenship Behavior, and Turnover on Organizational Effectiveness: A Unit - level, Longitudinal Study 显示文摘 | Koys D J | 2001 | Personnel Psychology2001，，54： | 1 |
| 10 | Effect of abutment tooth color,cement color,and ceramic thickness on the resulting optical color of a CAD/CAM glass-ceramic lithium disilicate reinforced crown显示文摘 | Yada Chaiyabutr John C Kois Dene LeBeau | 2011 | J Prosthet Dent2011，105，： | 1 |
| 11 | Influence of preparation design and existing condition of tooth structure on load to failure of ceramic laminate veneers显示文摘 | Kyle K. Schmidt Yada Chiayabutr Keith M. Phillips John C. Kois | 2011 | The Journal of Prosthetic Dentistry2011，，6： | 1 |
| 12 | Identification of carcinogens in cooking oil fumes显示文摘 | Chiang T A Wu P F Koi Y C | 1999 | Environ Res1999，81，1： | 1 |
| 13 | The mechanisms of placental viralinfection显示文摘 | Koi H Zhang J Parry S | 2001 | Ann N Y Acad Sci2001，943，： | 1 |
| 14 | Prolonged impact of earthquake-induced landslides on sediment yield in a mountain watershed: The Tanzawa region, Japan显示文摘 | Takashi Koi Norifumi Hotta Ituro Ishigaki Norimasa Matuzaki Yoshimi Uchiyama Masakazu Suzuki | 2008 | Geomorphology2008，，4： | 1 |
| 15 | Outcome of percutaneous surgery stratified according to body mass index and kidney stone size显示文摘 | Sergeyev I Koi PT Jacobs SL | 2007 | Surg Laparosc Endosc Percutan Tech2007，17，3： | 1 |
| 16 | Towards automatic merging of domain ontologies:the HCONE-merge approach显示文摘 | Kois K Vouros G A Sterqiou K | 2006 | Web Semantics2006，4，1： | 1 |
| 17 | Biomass reduction and mineralization increase due to the ciliate Tetrahylnena pyriformis gazing on the baeterium Pseudomonas fluoreseens 显示文摘 | Ratsak C H Koi B W van Verseveld H W | 1994 | Wat Sci Tech1994，29，7： | 1 |
| 18 | The effects of employee satisfaction, organizational citizenship behavior, and tumover on organizational effective- ness : A unit-level, longitudinal study 显示文摘 | Koys DJ | 2001 | Personnel Psychol- ogy2001，54，1： | 1 |
| 19 | The restorative-periodontal interface:biological parameters显示文摘 | Kois J C | 1996 | Periodontology 20001996，11，1： | 1 |
| 20 | Prolonged impact of earthquake-induced landslides on sediment yield in a mountain watershed : The Tanzawa region, Japan 显示文摘 | Takashi Koi Norifumi Hotta Ituro Ishigaki | 2008 | Geomorphology2008，101，3： | 1 |
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