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| 1 | Pulmonary complications of transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘Transcatheter arterial chemoembolization(TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma(HCC). Post-TACE pulmonary complications resulting in acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous(AV) shunts within the hyper-vascular HCC. We review herein the literature on pulmonary complications related to TACE for HCC. Post-TACE pulmonary complications have included pulmonary oil embolism, interstitial pneumonitis, chemical pneumonitis, ALI, ARDS, lipoid pneumonia, acute eosinophilic and neutrophilic pneumonia, bilious pleuritis, pulmonary abscess, pulmonary tumor embolism, and possibly pulmonary metastasis with HCC. The risk factors associated with post-TACE pulmonary complications identified in the literature include large hyper-vascular HCC with AV shunts, large-volume Lipiodol infusion, and embolization via the right inferior phrenic artery. However, the absence of known risk factors is not a guarantee against serious complications. An astute awareness of the potential post-TACE pulmonary complications should expedite appropriate therapeutic interventions and increase potential for early recovery. | Quan M Nhu Harry Knowles Paul J Pockros Catherine T Frenette | 2016 | World Journal of Respirology2016，6，3： | 4 |
| 2 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 3 | Emergence in Asia of foot-and-mouth disease viruses with altered host range:characterization of alteration in the 3A protein显示文摘 | Knowles N J Davies P R Henry T | 2001 | J Virol2001，75，3： | 2 |
| 4 | Methane emission from fen, bog and swamp peatlands in Quebec 显示文摘 | Moore T R Knowles R | 1990 | Biogeochemistry1990，11，： | 1 |
| 5 | Classification of entero- viruses based on molecular and biological properties显示文摘 | Hypia T Hovi T Knowles N J | 1997 | J Gen Virol1997，78，1： | 1 |
| 6 | Utilization of aliphatic compounds by acidophilic heterotrophic bacteria: The potential for bioremediation of acidic wastewaters contaminated with toxic organic compounds and heavy metals显示文摘 | Knowles C J | 2000 | FEMS Microbiology Letters2000，192，： | 1 |
| 7 | Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes显示文摘 | Knowles TJ Jeeves M Bobat S Dancea F McClelland D Palmer T Overduin M Henderson IR | | 0，，05： | 1 |
| 8 | Methane production and consumption in temperate and subarctic peat soils: response to temperature and Ph显示文摘 | Dunfield P Knowles R Dumont R Moore T R | 2003 | Soil Biology and Biochemistry2003，25，3： | 1 |
| 9 | Anodic Bonding显示文摘 | Knowles K M Van Helvoort A T J | 2006 | International Materials Reviews2006，，51： | 1 |
| 10 | Effects of lairage time on body temperature and glycogen reserves of broiler chickens held in transport modules 显示文摘 | WARRISS P D KNOWLES T G BROWN S N | 1999 | Vet Rec1999，145，8： | 1 |
| 11 | Cost of injuries from a prospective cohort study of North Carolina high school athletes显示文摘 | SB Knowles SW Marshall T Miller | | 0，，： | 1 |
| 12 | Effects of dietary fiber or fat in low-crude protien, crystalline amino acid-supplemented diets for finishing pigs显示文摘 | Knowles T A Southern L L Bidner T D | 1998 | J Anim Sci1998，76，： | 1 |
| 13 | Conserved recombinant antigens of Anaplasma marginale and Babesia equifor serologic diagnosis 显示文摘 | Knowles D P Perryman L E Mc Elwain T F | 1995 | Vet Parasitol1995，5，7： | 1 |
| 14 | M241 (CD1) expression on B lymphocytes 显示文摘 | Knowles R W Keever C | 1987 | J Immunol1987，138，： | 1 |
| 15 | The role of nitric oxide in osteoarthritis 显示文摘 | Vuolteenaho K Moilanen T Knowles RG | 2007 | Scand J Rheumato12007，4，： | 1 |
| 16 | Effects on cattle of transport by road for up to 15 hours 显示文摘 | WARRISS P BROWN S KNOWLES T | 1995 | Veterinary Record1995，136，13： | 1 |
| 17 | The generation and persistence of genetic variation in foot-and-mouth disease virus 显示文摘 | Haydon D T Samuel A R Knowles N J | 2001 | Prev Vet Med2001，51，： | 1 |
| 18 | Anodic bonding显示文摘 | K M Knowles A T J Van Helvoort | 2006 | International Materials2006，951，： | 1 |
| 19 | Classification of entero-viruses based on molecular and biological properties显示文摘 | HyypiaT Hovi T Knowles NJ | 1997 | J GenVirol1997，78，1： | 1 |
| 20 | Statistics and characteristics of pemrafrost and ground ice distribution in the Northern Hemisphere 显示文摘 | Zhang T Barry R G Knowles K | 1999 | Polar Geography1999，23，2： | 1 |
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