|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization显示文摘The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency. | Jingyuan Yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan Yang Mingcan Yang Tan Ju Wen Zeng Chuhong Zhu | 2018 | Science China(Life Sciences)2018，61，10： | 5 |
| 2 | Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells显示文摘Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has also been shown to promote an immunosuppressive tumor microenvironment.Previous studies demonstrated that focal adhesion kinase inhibitors(FAKi)in clinical development inhibit the infiltration of suppressive myeloid cells and T regulatory(T regs)cells,and subsequently enhance effector T cell infiltration.FAK inhibitors in clinical development have not been investigated in combination with RT in preclinical murine models or clinical studies.Thus,we investigated the impact of FAK inhibition on RT,its potential as an RT sensitizer and immunomodulator in a murine model of PDAC.Methods:We used a syngeneic orthotopic murine model to study the effect of FAKi on hypofractionated RT.Results:In this study we showed that IN10018,a small molecular FAKi,enhanced antitumor response to RT.Antitumor activity of the combination of FAKi and RT is T cell dependent.FAKi in combination with RT enhanced CD8+T cell infiltration significantly in comparison to the radiation or FAKi treatment alone(P<0.05).FAKi in combination with radiation inhibited the infiltration of granulocytes but enhanced the infiltration of macrophages and T regs in comparison with the radiation or FAKi treatment alone(P<0.01).Conclusions:These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy. | Arsen Osipov Alex B.Blair Juliane Liberto Jianxin Wang Keyu Li Brian Herbst Yao Xu Shiqi Li Nan Niu Rufiaat Rashid Ding Ding Yanan Liu Zaiqi Wang Christopher L.Wolfgang Richard A.Burkhart Daniel Laheru Lei Zheng | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway显示文摘Vesicle Protein Sorting 35(VPS35)is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma(HCC).However,the role of VPS35 in HCC metastasis and the underlying mechanisms remain largely unclear.In this study,we observed that overexpression of VPS35 enhanced hepatoma cell invasion and metastasis by inducing epithelialemesenchymal transition(EMT)-related gene expression.Conversely,knockout of VPS35 significantly inhibited hepatoma cell migration and invasion.Furthermore,depletion of VPS35 decreased the lung metastasis of HCC in nude mice.By transcriptome analysis,we determined that VPS35 promoted HCC metastasis by activating the Wnt/non-canonical planar cell polarity(PCP)pathway.Mechanistically,VPS35 activated the PCP pathway by regulating membrane sorting and trafficking of Frizzled-2(FZD2)and ROR1 in hepatoma cells.Collectively,our results indicate that VPS35 promotes HCC metastasis via enhancing the Wnt/PCP signaling,thus providing a potential prognostic marker and therapeutic target for HCC. | Yi Liu Haijun Deng Li Liang Guiji Zhang Jie Xia Keyue Ding Ni Tang Kai Wang | 2021 | Genes & Diseases2021，8，2： | 2 |
| 4 | A lower confidence bound for the change point after a sequential CUSUM test显示文摘 | Ding Keyue | 2003 | Journal of Statistical Planning and Inference2003，115，： | 1 |
| 5 | Specific Index System of Ecological Balanced Fertilization for Maize显示文摘This paper studied the index system of ecological balanced fertilization for maize by data mining method based on data of'3414 fertilizer field trials'of maize by published papers from national soil testing and recommendation since 2005.The results and conclusions were as follows.①Soil nutrient content could not be used as indicator of fertilizer application of maize.②The conceptual model of N conversion rate of maize for plot was Y N≈a+b×optimum production-c×optimum fertilizer amount of N-d×optimum phosphorus application amount-e×optimum potassium application amount-f×temperature in growth season-g×rainfall in growth season.The conceptual model of P conversion rate of maize for plot was Y P≈a+b×optimum phosphorus application amount-c×optimum nitrogen application amount-d×optimum potassium application amount.The conceptual model of K conversion rate of maize for plot was Y K≈a+b×optimum yield-c×optimum nitrogen application amount-d×optimum phosphorus application amount-e×optimum potassium application amount-f×temperature in growth season-g×rainfall in growth season.③The conceptual model of the optimum fertilizer amount of N of maize for plot was Y N≈a+b×optimum phosphorus application amount+c×optimum potassium application amount+d×temperature in growing season+e×rainfall in growing season,and the conceptual model of the optimum fertilizer amount of P was Y P≈a+b×optimum nitrogen application amount,and the conceptual model of the optimum fertilizer amount of K was Y K≈a+b×optimum nitrogen application amount+c×temperature in growth season+d×rainfall in growth season-e×optimum yield.④The conceptual model of relative abundance-deficiency value of soil N of maize for plot was that Y N≈a,and the conceptual model of relative abundance-deficiency value of soil P was Y P≈a,and the conceptual model of relative abundance-deficiency value of soil K was Y K≈a+b×optimum nitrogen application amount+c×optimum phosphorus application amount. | Keyu LIN Hongyan ZHENG Zhiping HUANG Jian DING Changhong MI Shutian LIU Xianda HOU Shuojin WANG Ling LU Yanlin HOU | 2020 | Meteorological and Environmental Research2020，11，5： | 0 |
| 6 | Frequency domain based super-resolution method for mixed-resolution multi-view images显示文摘Super-resolution(SR) techniques, which are based on single or multi-frame low-resolution(LR) images, have been extensively investigated in the last two decades. Mixed-resolution multiview video format plays an important role in three-dimensional television(3DTV) coding scheme. Previous work considers multiview or multi-camera images and videos at the same resolution,which performs well under the planar model without or with little projection error among the videos captured by different cameras.In recent years, several researchers have discussed the SR problem in mixed-resolution multi-view video format, where the superresolved image is created using the up-sampled version of the LR image and the high frequency components extracted from the warped image in the adjacent high-resolution(HR) views. Unfortunately, the output HR images suffer from artifacts caused by depth error. To obtain the detailed texture and edge information from the HR image as much as possible, while preserving the structure of the LR image, a novel SR reconstruction algorithm is proposed.The algorithm is composed of three components: the structure term, the detail information term, and the regularization term. The first term preserves the structure similarity of the LR image; the second term extracts detailed information from the adjacent HR image; and the last term ensures the uniqueness of the solution.Experimental results show the effectiveness and robustness of the proposed algorithm, which achieves high performance both subjectively and objectively. | Zhizhong Fu Yawei Li Yuan Li Lan Ding Keyu Long | 2016 | Journal of Systems Engineering and Electronics2016，27，6： | 0 |
| 7 | Advances in the Application of Perovskite Materials显示文摘Nowadays, the soar of photovoltaic performance of perovskite solar cells has set off a fever in the study of metal halide perovskite materials. The excellent optoelectronic properties and defect tolerance feature allow metal halide perovskite to be employed in a wide variety of applications. This article provides a holistic review over the current progress and future prospects of metal halide perovskite materials in representative promising applications, including traditional optoelectronic devices(solar cells, light-emitting diodes, photodetectors, lasers), and cutting-edge technologies in terms of neuromorphic devices(artificial synapses and memristors) and pressure-induced emission. This review highlights the fundamentals, the current progress and the remaining challenges for each application, aiming to provide a comprehensive overview of the development status and a navigation of future research for metal halide perovskite materials and devices. | Lixiu Zhang Luyao Mei Kaiyang Wang Yinhua Lv Shuai Zhang Yaxiao Lian Xiaoke Liu Zhiwei Ma Guanjun Xiao Qiang Liu Shuaibo Zhai Shengli Zhang Gengling Liu Ligang Yuan Bingbing Guo Ziming Chen Keyu Wei Aqiang Liu Shizhong Yue Guangda Niu Xiyan Pan Jie Sun Yong Hua Wu‑Qiang Wu Dawei Di Baodan Zhao Jianjun Tian Zhijie Wang Yang Yang Liang Chu Mingjian Yuan Haibo Zeng Hin‑Lap Yip Keyou Yan Wentao Xu Lu Zhu Wenhua Zhang Guichuan Xing Feng Gao Liming Ding | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 8 | Fabrication of Z-type barium ferrite/silica composites with enhanced microwave absorption显示文摘The Z-type barium ferrite/silica composites(Z-BCF/SiO2)were fabricated by in situ chemical synthesis method.The composition,structure,morphology and magnetic behavior of the composites were characterized by chemical analysis,IR,XRD,SEM,TEM and VSM.The results indicated that there were some interactions between two components in the Z-BCF/SiO2 composites due to the coating of SiO2 on the Z-BCF particles.The magnetic properties of the Z-BCF/SiO2 composites were evidently less than that of the Z-BCF,owing to the small volume fraction of magnetic components in the samples.Due to the good transmission and loss properties on electromagnetic waves,the composites were better at microwave absorption than the parent component.Therefore,this research laid a foundation for the fabrication of highly efficient microwave absorbing material with enhanced wave impedance matching. | SHEN JunHai CHEN KeYu LI LiangChao DING Yan LI JuanBi KONG WeiQiu | 2014 | Science China(Technological Sciences)2014，57，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员