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您的检索式：作者名="Keyuan Chen"
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| 1 | Identification and Characterization of a Distinct Strain of Beak and Feather Disease Virus in Southeast China显示文摘Beak and feather disease virus(BFDV) is an infectious agent responsible for feather degeneration and beak deformation in birds. In March 2017, an epidemic of psittacine beak and feather disease(PBFD) struck a farm in Fuzhou in the Fujian Province of southeast China, resulting in the death of 51 parrots. In this study, the disease was diagnosed and the pathogen was identified by PCR and whole genome sequencing. A distinct BFDV strain was identified and named as the FZ strain.This BFDV strain caused severe disease symptoms and pathological changes characteristic of typical PBFD in parrots, for example, loss of feathers and deformities of the beak and claws, and severe pathological changes in multiple organs of the infected birds. Phylogenetic analysis showed that the FZ strain was more closely related to the strain circulating in New Caledonia than the strains previously reported in China. Nucleotide homology between the FZ strain and other 43 strains of BFDV ranged from 80.0% to 92.0%. Blind passage experiment showed that this strain had limited replication capability in SPF Chicken Embryos and DF-1 Cells. Furthermore, the capsid(Cap) gene of this FZ strain was cloned into the p GEX-4 T-1 expression vector to prepare the polyclonal anti-Cap antibody. Western blotting analysis using the anti-Cap antibody further confirmed that the diseased parrots were infected with BFDV. In this study, a PBFD and its pathogen was identified for the first time in Fujian Province of China, suggesting that future surveillance of BFDV should be performed. | Yanmei Ma Xiaoyong Chen Keyuan Chen Xiancheng Zeng Shili Yang Wei Chang Yao Tang Xiaoli Chen Song Wang Ji-Long Chen | 2020 | Virologica Sinica2020，35，1： | 1 |
| 2 | Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis显示文摘 | Zhangfeng Zhong Xiuping Chen Wen Tan Zengtao Xu Keyuan Zhou Tie Wu Liao Cui Yitao Wang | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 3 | STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway显示文摘Dear Editor,Rheumatoid arthritis(RA),which is the most common inflammatory arthritis disease,as well as a kind of most prevalent autoimmune disease,affects 1–3%population all over the world.1 Currently available treatments can reduce the disability rate of patients with RA to some extent,but they cannot completely block the inflammatory joint destruction and relieve the pain that comes with it.Our previous study found that Neuron Navigator 2(NAV2)increased significantly in RA and was regulated by transcription factor E2F1.2 However,it is still unclear why NAV2 is elevated at the genetic level in RA fibroblast-like synoviocytes(FLS).Additionally,RA’s exact pathological mechanisms and therapeutic targets are also not fully understood.Hence,an indepth study of the pathogenesis of RA is urgently needed. | Ran Wang Jianghong Cai Keyuan Chen Menglin Zhu Zhaoyi Li Hua Liu Tiantian Liu Jianchun Mao Qian Ding Yi Zhun Zhu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
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