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| 1 | Overexpression of PTEN Induces Cell Growth Arrest and Apoptosis in Human Breast Cancer ZR-75-1 Cells显示文摘磷酸酶并且十在相当或相同的事物(PTEN ) 是一个肿瘤压制或基因定位了 athumanchromosome 10q23,可能在房间增长,房间周期和癌症房间的 apoptosis 起一个重要作用。在这研究,真核细胞的表示向量 pBP-wt-PTEN (包含 wild-typePTEN 基因) 并且 pBP-G129R-PTEN (包含变异的 PTEN 基因) 习惯于 transfect 胸 cancerZR-75-1 房间。在转染以后,表示 PTEN 的 ZR-75-1 房间被获得并且测试。蓝排除试金证明有 pBP-wt-PTEN 的房间 transfected 的生长率是比有 pBP-G129R-PTEN 的控制房间 transfected 的显著地低的。由流动 cytometry 的房间周期的分析证明到 S 阶段的从 Gx 的前进在表示野类型的 PTEN 的房间被逮捕。apoptosis 的一些典型词法变化也与 pBP-G129R-PTEN 与 pBP-wt-PTEN 在房间 transfected,然而并非在那些 transfected 被观察。这学习在在 ZR-75-1 细胞的 PTEN 的表示上导致细胞生长拘捕和 apoptosis 的 hows。 | Xiangyong LI Guanping LIN Binhua WU Xin ZHOU Keyuan ZHOU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 8 |
| 2 | Direct observation of metastable face-centered cubic Sb2Te3 crystal显示文摘尽管阶段变化记忆技术在过去的二十年急速地发展了,关键切换材料的认知仍然忽视一个重要成员,以脸为中心的立方的 Sb 2 Te 3 。除了著名平衡六角形的 Sb 2 Te 3 水晶,我们证明亚稳的以脸为中心的立方的 Sb 是 2 Te 3 阶段确实存在。如此的亚稳的晶体包含随机占据 cationic 格子地点的空缺的大集中。以脸为中心对 Sb 2 Te 3, 由空缺聚集伴随了,与 Ge 2 Sb 2 Te 5 合金。我们证明像共有原子价的契约在亚稳的 Sb 2 Te 3 水晶,从理想的反响的特征背离。如果一种合适的做技术被采用,亚稳的 Sb 2 Te 3 阶段能为认识到 reversibly 快速、低精力的阶段变化存储器应用程序是有希望的。我们的学习可以在新奇阶段变化材料的设计提供新卓见进商品化的 Ge-Sb-Te 系统和帮助增加阶段变化存储器设备的表演。 | Yonghui Zheng Mengjiao Xia Yan Cheng Feng Rao Keyuan Ding Weili Liu Yu Jia Zhitang Song Songlin Feng | 2016 | Nano Research2016，9，11： | 5 |
| 3 | 海盗问题及中国的对策显示文摘前言 从传统上,海盗行为就被公认为是人类的公敌。海盗在海洋上进行杀人、抢劫等犯罪行为,由于这些行为残忍地违背人性,决定了其在任何地方都应受到惩罚。根据国际商会国际海事局海盗报告中心的报告,1999年1月1日至6月30日,全球共发生了115起海盗案件。早在1998年联合国大会就号召所有国家,特别是在受到影响的区域内的沿海国家,采取一切必要、合适的措施,阻止和打击海上犯罪行为和武装劫掠事件。 | 海商 Zou Keyuan | 2001 | 中国远洋航务公告2001，，5： | 3 |
| 4 | OXIDATION OF GALENA IN AMMONIUM CARBONATE SOLUTION AND APPLIED REACTOR显示文摘OXIDATIONOFGALENAINAMMONIUMCARBONATESOLUTIONANDAPPLIEDREACTOR￥Gong,Qian;Gong,Yajun;Cao,Changlin;Lu,Keyuan(InstituteofChemical... | Gong, Qian Gong, Yajun Cao, Changlin Lu, Keyuan(Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080) | 1995 | 中国有色金属学会会刊:英文版1995，5，3： | 2 |
| 5 | Genetic control of compound leaf development in the mungbean(Vigna radiata L.)显示文摘Many studies suggest that there are distinct regulatory processes controlling compound leaf development in different clades of legumes.Loss of function of the LEAFY(LFY)orthologs results in a reduction of leaf complexity to different degrees in inverted repeat-lacking clade(IRLC)and non-IRLC species.To further understand the role of LFY orthologs and the molecular mechanism in compound leaf development in non-IRLC plants,we studied leaf development in unifoliate leaf(un)mutant,a classical mutant of mungbean(Vigna radiata L.),which showed a complete conversion of compound leaves into simple leaves.Our analysis revealed that UN encoded the mungbean LFY ortholog(VrLFY)and played a significant role in leaf development.In situ RNA hybridization results showed that STM-like KNOXI genes were expressed in compound leaf primordia in mungbean.Furthermore,increased leaflet number in heptafoliate leaflets1(hel1)mutants was demonstrated to depend on the function of VrLFY and KNOXI genes in mungbean.Our results suggested that HEL1 is a key factor coordinating distinct processes in the control of compound leaf development in mungbean and its related non-IRLC legumes. | Keyuan Jiao Xin Li Shihao Su Wuxiu Guo Yafang Guo Yining Guan Zhubing Hu Zhenguo Shen Da Luo | 2019 | Horticulture Research2019，6，1： | 2 |
| 6 | Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells显示文摘 | Jing Liua Chengwei Hea Keyuan Zhoub | 2009 | Biochem Biophys Res Commun2009，378，2： | 1 |
| 7 | China’s U-Shaped Line in the South China Sea Revisited显示文摘 | Zou Keyuan | 2012 | Ocean Development & International Law2012，，1： | 1 |
| 8 | Hydrometallurgy显示文摘 | Lu Keyuan Chenjiayong | 1986 | (17):73 - 831986，，17： | 1 |
| 9 | Historic Rights in International Law and China's Practice显示文摘 | Keyuan Zou | 2001 | Ocean Development and International Law2001，，32： | 1 |
| 10 | Identification and Characterization of a Distinct Strain of Beak and Feather Disease Virus in Southeast China显示文摘Beak and feather disease virus(BFDV) is an infectious agent responsible for feather degeneration and beak deformation in birds. In March 2017, an epidemic of psittacine beak and feather disease(PBFD) struck a farm in Fuzhou in the Fujian Province of southeast China, resulting in the death of 51 parrots. In this study, the disease was diagnosed and the pathogen was identified by PCR and whole genome sequencing. A distinct BFDV strain was identified and named as the FZ strain.This BFDV strain caused severe disease symptoms and pathological changes characteristic of typical PBFD in parrots, for example, loss of feathers and deformities of the beak and claws, and severe pathological changes in multiple organs of the infected birds. Phylogenetic analysis showed that the FZ strain was more closely related to the strain circulating in New Caledonia than the strains previously reported in China. Nucleotide homology between the FZ strain and other 43 strains of BFDV ranged from 80.0% to 92.0%. Blind passage experiment showed that this strain had limited replication capability in SPF Chicken Embryos and DF-1 Cells. Furthermore, the capsid(Cap) gene of this FZ strain was cloned into the p GEX-4 T-1 expression vector to prepare the polyclonal anti-Cap antibody. Western blotting analysis using the anti-Cap antibody further confirmed that the diseased parrots were infected with BFDV. In this study, a PBFD and its pathogen was identified for the first time in Fujian Province of China, suggesting that future surveillance of BFDV should be performed. | Yanmei Ma Xiaoyong Chen Keyuan Chen Xiancheng Zeng Shili Yang Wei Chang Yao Tang Xiaoli Chen Song Wang Ji-Long Chen | 2020 | Virologica Sinica2020，35，1： | 1 |
| 11 | Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis显示文摘 | Zhangfeng Zhong Xiuping Chen Wen Tan Zengtao Xu Keyuan Zhou Tie Wu Liao Cui Yitao Wang | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 12 | Discontinuous free-form lens design for prescribed irradiance 显示文摘 | Wang Lin Qian Keyuan Luo Yi | 2007 | Applied Optics2007，46，18： | 1 |
| 13 | Historic rights in international law and in China's practice显示文摘 | Keyuan Z | 2001 | Ocean Development&International Law2001，32，2： | 1 |
| 14 | The Chinese Traditional Maritime Delimitation Line in the South China Sea and its Legal Consequences for the Resolution of the Dispute over the Spratly Islands显示文摘 | | 1999 | I JMCL1999，14，1： | 1 |
| 15 | Enhanced liver targeting of 5-fluorouracil using galactosylated human serum albumin as a carrier molecule显示文摘 | CAI Chun ZHOU Keyuan WU Yong | 2006 | J Drug Target2006，14，2： | 1 |
| 16 | China's U-Shaped Line in The South China Sea Revisited 显示文摘 | Zou Keyuan | 2012 | Ocean Development & International Law2012，43，1： | 1 |
| 17 | The Chinese Traditional Maritime Boundary Line in the South China Sea and Its Legal Consequences for the Resolution of the Dispute over the Spratly Islands显示文摘 | Z. Keyuan | 1999 | The International Journal of Marine and Coastal Law1999，，1： | 1 |
| 18 | The Chinese traditional maritime boundary line in the South China Sea and its legal consequences for the resolution of the dispute over the Spratly Islands显示文摘 | KEYUAN Z | 1999 | International Journal of Marine & Coastal Law1999，，1： | 1 |
| 19 | Historic right in international law and Chinese practice 显示文摘 | KEYUAN Z | 2001 | Ocean Development & International Law2001，，2： | 1 |
| 20 | Clinical value of ^(18)F-FDG PET/CT in assessing suspicious relapse after rectal cancer resection显示文摘AIM:To evaluate the value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) in the restaging of resected rectal cancer.METHODS:From January 2007 to Sep 2008,21 patients who had undergone curative surgery resection for rectal carcinoma with suspicious relapse in conventional imaging or clinical findings were retrospectively enrolled in our study.The patients underwent 28 PET/CT scans(two patients had two scans,one patient had three and one had four scans).Locoregional recurrences and/or distant metastases were confirmed by histological analysis or clinical and imaging follow-up.RESULTS:Final diagnosis was confirmed by histopathological diagnosis in 12 patients(57.1) and by clinical and imaging follow-up in nine patients(42.9).Eight patients had extrapelvic metastases with no evidence of pelvic recurrence.Seven patients had both pelvic recurrence and extrapelvic metastases,and two patients had pelvic recurrence only.18F-FDG PET/CT was negative in two patients and positive in 19 patients.18F-FDG PET/CT was true positive in 17 patients and false positive in two.The accuracy of 18F-FDG PET/CT was 90.5,negative predictive value was 100,and positive predictive value was 89.5.Five patients with perirectal recurrence underwent 18F-FDG PET/CT image guided tissue core biopsy.18F-FDG PET/CT also guided surgical resection of pulmonary metastases in three patients and monitored the response to salvage chemotherapy and/or radiotherapy in four patients.CONCLUSION:18F-FDG PET/CT is useful for evaluating suspicious locoregional recurrence and distant metastases in the restaging of rectal cancer after curative resection. | Long Sun,Wei-Min Pan,Zuo-Ming Luo,Ji-Hong Wei,Long Zhao,Hua Wu,Minnan PET Center and Department of Nuclear Medicine,the First Hospital of Xiamen University,Xiamen 316003,Fujian Province,China Yong-Song Guan,State Key Laboratory of Biotherapy,West China Medical School,Sichuan University,Gaopeng Street,Keyuan Road 4,Chengdu 610041,Sichuan Province,China | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 1 |
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