| 2 | A prospective cohort study on serum A20 as a prognostic biomarker of aneurysmal subarachnoid hemorrhage显示文摘BACKGROUND:A20 may be a neuroprotective factor.Herein,we aimed to investigate whether serum A20 levels were associated with disease severity,delayed cerebral ischemia(DCI),and outcome after aneurysmal subarachnoid hemorrhage(aSAH).METHODS:In this prospective cohort study containing 112 aSAH patients and 112 controls,serum A20 levels were quantified.At 90 d poststroke,Modified Rankin Scale(MRS) scores≥3 were defined as a poor outcome.All correlations and associations were assessed using multivariate analysis.RESULTS:Compared with controls,there was a significant elevation of serum A20 levels in patients(median 123.7 pg/mL vs.25.8 pg/mL;P<0.001).Serum A20 levels were independently correlated with Hunt-Hess scores(β 9.854;95% confidence interval [95% CI] 2.481-17.227,P=0.009) and modified Fisher scores(β 10.349,95% CI 1.273-19.424,P=0.026).Independent associations were found between serum A20 levels and poor outcome(odds ratio [OR] 1.015,95%CI 1.000-1.031,P=0.047) and DCI(OR 1.018,95% CI 1.001-1.035,P=0.042).Areas under the curve for predicting poor outcome and DCI were 0.771(95% CI 0.682-0.845) and 0.777(95% CI 0.688-0.850),respectively.Serum A20 levels ≥128.15 pg/mL predicted poor outcome,with a sensitivity of 73.9% and specificity of 74.2%,and A20 levels ≥160.55 pg/mL distinguished the risk of DCI with65.5% sensitivity and 89.2% specificity.Its ability to predict poor outcome and DCI was similar to those of Hunt-Hess scores and modified Fisher scores(both P>0.05).CONCLUSION:Enhanced serum A20 levels are significantly associated with stroke severity and poor clinical outcome after aSAH,implying that serum A20 may be a potential prognostic biomarker for aSAH. | Tian Yan Ziyin Chen Shengdong Zou Zefan Wang Quan Du Wenhua Yu Wei Hu Yongke Zheng Keyi Wang Xiaoqiao Dong Shuangyong Dong | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 3 | Single-cell transcriptome landscape and antigen receptor dynamic during SARS-CoV-2 vaccination显示文摘Vaccination by inactivated vaccine is an effective strategy to prevent the COVID-19pandemic.However,the detailed molecular immune response at single-cell level is poorly un-derstood.In this study,we systematically delineated the landscape of the pre-and post-vaccination single-cell transcriptome,TCR(T cell antigen receptor)and BCR(B cell antigen re-ceptor)expression profile of vaccinated candidates.The bulk TCR sequencing analysis of COV-ID-19 patients was also performed.Enrichment of a clonal CD8+T cell cluster expressingspecific TCR was identified in both vaccination candidates and COVID-19 patients.These clonalCD8+T cells showed high expression of cytotoxicity,phagosome and antigen presentationrelated genes.The cellecell interaction analysis revealed that monocytes and dendritic cellscould interact with these cells and initiate phagocytosis via ICAM1-ITGAM and ITGB2 signaling.Together,our study systematically deciphered the detailed immunological response duringSARS-CoV-2 vaccination and infection.It may facilitate understanding the immune responseand the T-cell therapy against COVID-19. | Xiaojian Cao Xiaohua Chen Yaqi Zhu Xiaojuan Gou Keyi Yan Bing Yang Dong Men Lei Liu Yong-an Zhang Gang Cao | 2023 | Genes & Diseases2023，10，4： | 0 |
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