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| 1 | Using Group Learning Activities in the Task-based Composition Class显示文摘Research in general education has pointed to the effectiveness of task-based language teaching (TBLT). Task-based syllabi focus on tasks which require students to use the language for communication, but more specifically, on tasks which will be used outside of the classroom. | Anita M.CoPeland Kess Joseph F.Kess | 2001 | 国外外语教学2001，，4： | 5 |
| 2 | Evidence of insecticide resistance selection in wildmosquitoes due to agricultural pesticide use显示文摘Background:The wetlands used for some agricultural activities constitute productive breeding sites for many mosquito species.Thus,the agricultural use of insecticide targeting other pests may select for insecticide resistance in malaria mosquitoes.The purpose of this study is to clarify some knowledge gaps on the role of agrochemicals in the development of insecticide resistance in malaria vectors is of utmost importance for vector control.Methods:Using the CDC bottle test and the log-probit analysis,we investigated for the first time the resistance levels ofAnopheles coluzzii mosquitoes to neonicotinoids,insecticides used exclusively for crop protection in C?te d’Ivoire.The study was conducted in two agricultural regions(Tiassale and Gagnoa)and one non-agricultural region(Vitre)between June and August 2017 using clothianidin,acetamiprid and imidacloprid.Results:Mosquito populations from Tiassale and Gagnoa(agricultural settings)were determined to be resistant to acetamiprid with mortality rates being<85%at 24 h post-exposure.In Vitre(non-agricultural area)however,the mosquito population was susceptible to acetamiprid.In all three localities,mosquito populations were resistant to imidacloprid(mortality rates were 60%in Vitre,37%in Tiassale,and 13%in Gagnoa)and completely susceptible to clothianidin(100%mortality).An.coluzzii represented 100%of mosquito collected in Gagnoa,86%in Tiassale and 96%in Vitre.Conclusions:This study provides strong evidence that agricultural use of insecticides can cause insecticide resistance in malaria vector populations.Insecticide resistance driven by agrochemical usage should be considered when vector control strategies are developed. | Chouaibou Seidou Mouhamadou Sarah Souline de Souza Behi Kouadio Fodjo Marius Gonse Zoh Nestor Kesse Bli Benjamin Guibehi Koudou | 2019 | Infectious Diseases of Poverty2019，8，4： | 3 |
| 3 | Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability显示文摘瞄准:麦角固醇是有反肿瘤和 anti-angiogenic 活动的植物甾醇,但是是糟糕可溶的。在这研究,我们试图提高它的反肿瘤行动和口头的 bioavailability 经由 poly (lactide-co-glycolide )(PLGA ) nanoparticle encapsulation.Methods:装载麦角固醇的 PLGA nanoparticles (NPs/Erg ) 用乳剂 / 溶剂蒸发技术被准备。他们的物理化学的性质被描绘,并且他们对人的癌症房间线的 cytotoxicity 与 MTT 试金被评估。NPs/Erg 的 pharmacokinetics 和织物分发在老鼠和老鼠被调查, respectively.Results:NPs/Erg 在有 156.9 ± 的一种粒子尺寸的形状是球形的; 4.8 nm 和 -19.27±1.13 mV 的一个希腊语的第六个字母潜力,和有的可接受的封装效率和装载能力。NPs/Erg 比免费麦角固醇对人的癌症房间施加了强壮得多的 cytotoxicity,并且显示出显著地减少的 IC 50 价值(14.69 ± 0.48 μ在 glioma U251 房间的 g/mL;9.43 ± 0.52 μ在乳癌 MCF-7 房间的 g/mL;4.70 ± 0.41 μ在 hepatoma HepG2 房间的 g/mL ) 。在在老鼠的单个剂量的口头的管理以后, NPs/Erg 与免费麦角固醇相比随口头的 bioavailability 的 4.9 褶层增加显示了延长血浆发行量。在老鼠收到了 NPs/Erg 以后,在 NPs/Erg 的麦角固醇很快在胃被散布,肾,肝,大脑,怒气,并且在心和肺几乎不存在。在大脑的 NPs/Erg 的存在特别地与免费 ergosterol.Conclusion 相比被改进:PLGA nanoparticles 为糟糕可溶的麦角固醇担任一个有希望的搬运人并且显著地改进它的 bioavailability, biodistribution 并且在 vitro 反肿瘤活动。 | Hui-yun ZHANG Caleb Kesse FIREMPONG Yuan-wen WANG Wen-qian XU Miao-miao WANG Xia CAO Yuan ZHU Shan-shan TONG Jiang-nan YU Xi-ming XU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 3 |
| 4 | 4号染色体短臂微卫星多态性与鼻咽癌相关性的研究显示文摘鼻咽癌(NPC)是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中,那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异,即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者(IgA/VCA+)288例和EB病毒壳抗原IgA抗体阴性者(IgA/VCA—)346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂(4p15.1~q12)进行了微卫星精细扫描,在18Mb的范围内选择34个微卫星标记,包括319个等位基因,对其进行基因分型。比较分析NPC组和IgA/VCA+组等位基因频率结果显示,9个等位基因与鼻咽癌呈相关,其中5个为易感等位基因(OR=1.51~5.36,P=0.01~0.03),4个为限制性等位基因(OR值为0.3~0.71,P值为0.02~0.045)。比较分析IgA/VCA+组和IgA/VCA-组及比较所有IgA/VCA+者(包括NPC患者)和IgA/VCA-者等位基因频率的结果显示,12个等位基因与EB病毒壳抗原IgA抗体持续存在相关,其中3个在两组比较中均呈显著相关。等位基因D4S3241~136(P=0.004,OR=1.9,95%CI=1.2~3.0)和D4S3347-213(P=0.001,OR=1.6,95%CI=1.2~2.1)可增加EB病毒IgA/VCA抗体形成的危险,为易感基因;而等位基因D4S174.202(P=0.001,OR=0.5,95%CI=0.3~0.7)可限制IgA/VCA抗体的形成。但上述结果经多因素比较校正后,均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关,但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。 | 郭秀婵 O’BRIEN Stephen J WINKLER Cheryl SCOTT Kevin HUTCHESON Holli DAVID Victor KESSING Bailey 郑裕明 廖建 刘彦 GUY de The 曾毅 | 2006 | 遗传2006，28，7： | 2 |
| 5 | Identification of markers linked to disease resistenee genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions using segregating populations显示文摘 | MICHELMORE R W PARAN I KESSELI R V | 1991 | Proc Natl Acid Sci1991，88，： | 1 |
| 6 | Culture and Gender Differences in the Perception of Friendship by Adolescents显示文摘 | Maykel Verkuyten Kess Masson | | 0，，05： | 1 |
| 7 | CD4^+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis显示文摘 | Kess D Peters T Zamek J | 2003 | J Immunol2003，171，： | 1 |
| 8 | Identification of markers linked to disease-resistance genes by bulked segregant analysis:a rapid method to detect markers in specific genomic regions by using segregating populations显示文摘 | Michelmore R Paran I Kesseli R | | 0，，： | 1 |
| 9 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 10 | The world's largest macroalgal bloom in the Yellow Sea, China: formation and implications 显示文摘 | Liu D Y Kessing J K He P | 2013 | Estuarine Coastal and Shelf Science2013，129，： | 1 |
| 11 | Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations显示文摘 | Miehelmore RW Paran I Kesseli RV | 1991 | Proceedings of the National Academy of Sciences of the United States of America1991，88，21： | 1 |
| 12 | Identification of markers linked to disease resistance genes by bulked segregating populations显示文摘 | Michelmore RW Paran I Kesseli RV | 1991 | Proc Nat Acad Sci USA1991，88，： | 1 |
| 13 | Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations显示文摘 | Miehelmore RW Paran I Kesseli RV | 1991 | Proc Nail Acad Sci USA1991，88，： | 1 |
| 14 | Identification of markers linked to disease resistance genes by bulked segre-gant analysis:A rapid method to detect markers in specific genomic region is by using segregating population显示文摘 | MICHELMORE R W PARAN I KESSELI V | 1991 | Pro Natl Acs Sci1991，88，： | 1 |
| 15 | Identification of markers linked to disease-resistance genes by bulked segregant analysis:a rapid method to detect markers in specific genomic regions using segregating populations显示文摘 | Michelmore R W Paran I Kesseli R V | 1991 | Proc Natl Acad Sci USA1991，88，： | 1 |
| 16 | Identification of markers linked to disease-resistance genes by bulked seg- regant analysis:A rapid method to detect markers in spe- cific genomic regions by using segregating populations 显示文摘 | Michelmore R W Paran I Kesseli R V | 1991 | Proc Natl Aead Sci USA1991，88，21： | 1 |
| 17 | Time course of the discomfort in young patients undergoing orthodontic treatment显示文摘 | Wilson S Ngan P Kess B | 1989 | Pediatr Dent1989，11，2： | 1 |
| 18 | Identification of Markers Linked to Disease Resistance Genes by Bulk Segregant Analysis:a Rapid Method to Detect Markers in Specific Genomic Regions Using Segregating Populations显示文摘 | Paran I Kesseli R V | 1991 | Pro Natl Acad Sci USA1991，88，： | 1 |
| 19 | Identification of markers linked to disease-resistance genes by bulked segregant analysis: a rapid method to detect markers in specific genomic regions by using segregating populations 显示文摘 | Michelmore R W Paran I Kesseli R V | | Proc Natl Acad Sci U S A0，1，： | 1 |
| 20 | Early and persistent up-regulated expression of renal cortical osteopontin in experimental hydronephrosis显示文摘 | Diamond JR Kess Folts D Ricardo SD | 1995 | Am J Path1995，146，4： | 1 |
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