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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Ballistic limit equations for spacecraft shielding显示文摘 | Christiansen E L Kerr J H | | 0，，： | 2 |
| 3 | Flexible and deployable meteoroid/debris shielding for spacecraft 显示文摘 | CHRISTIANSEN E L KERR J H | 1999 | International Journal of Impact Engineering1999，23，： | 2 |
| 4 | Roles of epithelial cell derived periostin in TGF beta activa- tion,collagen production, and collagen gel elasticity in asthma显示文摘 | Sidhu S S Yuan S Innes A L Kerr S Woodruff P G Hou L | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 5 | Use of microresistivity image logs in the detailed reservoir architecture reconstruction of Glenn sandstone,Glenn Pool field,northeastern Oklahoma显示文摘 | Ye L Kerr D | 1995 | Tulsa Geological Society1995，，： | 1 |
| 6 | Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients显示文摘 | Kerr DR Kohan L | 2008 | Acta Orthop2008，79，2： | 1 |
| 7 | The behavioral phenotype of school-age children with shwachman diamond syndrome indicates neurocognitive dysfunction with loss of Shwachman-Bodian-Dia- mond syndrome gene function 显示文摘 | Kerr EN Ellis L Dupuis A | 2010 | J Pediatr2010，156，3： | 1 |
| 8 | Space shuttle meteoroid and orbital debris impact damage显示文摘 | Bernhard R P Christiansen E L Kerr J H | | 0，，： | 1 |
| 9 | The accuracy of p16/Ki-67 and HPV test in the detection of CIN2/3 in women diagnosed with ASC-US or LSIL显示文摘 | Possati-Resende J C Fregnani J H Kerr L M | 2015 | PLos One2015，10，01： | 1 |
| 10 | Autonomic function is impaired in elderly stroke survivors 显示文摘 | McLaren A Kerr S Allan L | 2005 | Stroke2005，36，5： | 1 |
| 11 | Manure composition of swine as affected by dietary protein and cellulose concentrations显示文摘 | Kerr B J Ziemer C J Trabue S L | 2006 | Journal of Animal Science2006，84，6： | 1 |
| 12 | Outgrowth of Salmonellae and physical property of albumen and vitelline membrane as influenced by egg storage conditions显示文摘 | Chen J Shallo Thesmar H Kerr W L | 2005 | Journal of Food Protection2005，68，12： | 1 |
| 13 | Geometric modeling of boundless grasps显示文摘 | XIONG Y L SANGER D J KERR D R | 1993 | International Journal Robotica1993，13，1： | 1 |
| 14 | The dynamic US aluminum recycling industry显示文摘 | KERR R L | 1999 | MBM1999，，11： | 1 |
| 15 | Safety, pharmacokinetics, and serum uric acid lowering effect of RDEA594, a novel uricosuric agent, in healthy volunteers 显示文摘 | Yeh L T Kerr B Shen Z | 2009 | Ann Rheum Dis2009，68，： | 1 |
| 16 | Combined effects of freezing rate, storage tem- perature and time on bread dough and baking properties显示文摘 | YI J Kerr W L | 2009 | Food Science and Technology2009，42，9： | 1 |
| 17 | Peanut skins-fortified peanut butters:effect of processing on the phenolic content,fiber content and antioxidant activity显示文摘 | MA Y KERR W L SWANSON R B | 2014 | Food Chemistry2014，145，： | 1 |
| 18 | The limits of organizational democracy显示文摘 | KERR J L | 2004 | Academy of Management Executive2004，18，3： | 1 |
| 19 | Manure composition of swine as affected by dietary protein and cellulose concentrations 显示文摘 | Kerr B J Zieiner C J Trabue S L | 2006 | Journal of Animal Science2006，84，： | 1 |
| 20 | Nanostructured materials for energy storage显示文摘 | NAZAR L F GOWARD G LEROUX F DUNCAN M HUANG H KERR T GAUBICHER J | 2001 | J Inorg Mater2001，3，3： | 1 |
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