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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Moving Mass Trim Control for Aerospace Vehicles 显示文摘 | Robinett R D Sturgis B R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 3 | Enhanced healing of cat corneal endothelial wounds by epidermal growth factor显示文摘 | Raphael B Kerr N C Shimizu R W | 1993 | In- vest Ophthalmol Vis Sci1993，34，7： | 1 |
| 4 | IGF-I dif- ferentially regulates IGF-binding protein expression in primary mammary fibroblasts and epithelial cells 显示文摘 | Fleming J M Leibowitz B J Kerr D E | 2005 | J Endocrinol2005，186，1： | 1 |
| 5 | Effect of dietary distillers dried grains with solubles on indicators of oxidative stress and immune function in growing pigs显示文摘 | WEBER T E KERR B J | 2011 | Livestock Science2011，142，1： | 1 |
| 6 | Wound healing dressings and drug delivery systems: A review显示文摘 | Joshua S B Kerr H M Howard N E S | 2008 | J Pharma- ceutical Sci2008，97，8： | 1 |
| 7 | Moving mass trim control for aerospace vehicles显示文摘 | Sturgis B R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 8 | Manure composition of swine as affected by dietary protein and cellulose concentrations显示文摘 | Kerr B J Ziemer C J Trabue S L | 2006 | Journal of Animal Science2006，84，6： | 1 |
| 9 | The relationship of femoral intercondylar notch width to height, weight , and sex in patients with intact anterior cruciate ligaments显示文摘 | Shelboume KD Kerr B | 2001 | Am J Knee Surg2001，14，2： | 1 |
| 10 | The road to ovulation:the role of oestrogens显示文摘 | Findlay J K Britt K Kerr J B | 2001 | Reprod Fertil Dev2001，13，： | 1 |
| 11 | Effects of adding fibrous feedstuffs to the diet of young pigs on growth performance,intestinal cytokines,and circulating acute-phase proteins显示文摘 | WEBER T E ZIEMER C J KERR B J | 2008 | Journal of Animal Science2008，86，4： | 1 |
| 12 | Safety, pharmacokinetics, and serum uric acid lowering effect of RDEA594, a novel uricosuric agent, in healthy volunteers 显示文摘 | Yeh L T Kerr B Shen Z | 2009 | Ann Rheum Dis2009，68，： | 1 |
| 13 | Peanut skins-fortified peanut butters:effect of processing on the phenolic content,fiber content and antioxidant activity显示文摘 | MA Y KERR W L SWANSON R B | 2014 | Food Chemistry2014，145，： | 1 |
| 14 | Manure composition of swine as affected by dietary protein and cellulose concentrations 显示文摘 | Kerr B J Zieiner C J Trabue S L | 2006 | Journal of Animal Science2006，84，： | 1 |
| 15 | Effect of performance and carcass characteristics of nursery to finisher pigs fed reduced crude protein,amino acid supplemented diet显示文摘 | Kerr B J Mcketth F K Easter R A | 1995 | J Anim Sci1995，73，： | 1 |
| 16 | Effect of dietary distillers dried grains with solubles on indicators of oxidative stress and immune function in growing pigs显示文摘 | WEBER T E KERR B J | 2011 | Livestock Science2011，142，1： | 1 |
| 17 | Pharmacodynamic, pharmacokinetic and tolerability evaluation concomitant administration of lesinuradand febuxostat in gout patients with hyperuricaemia 显示文摘 | Fleischmann R Kerr B Yeh L T | 2014 | Rheumatology2014，266，： | 1 |
| 18 | Effect of performance and carcass characteristics of nursery to finisher pigs fed reduced crude protein, amino acid supplemented diet 显示文摘 | KERR B J MCKETTH F K EASTER R A | 1995 | J AnimSci1995，73，： | 1 |
| 19 | Pharmacodynamic, phar- macokinetic and tolerability evaluation of concomitant administra- tion of lesinurad and febuxostat in gout patients with hyperuricae-mia 显示文摘 | Fleischmann R Kerr B Yeh LT | 2014 | Rheumatology2014，53，12： | 1 |
| 20 | A biomechanical analysis of the sticking region in the bench press显示文摘 | Elliott B C Wilson G J Kerr G K | 1989 | Medicine and Science in Sports and Exercise1989，，21： | 1 |
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