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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Moving Mass Trim Control for Aerospace Vehicles 显示文摘 | Robinett R D Sturgis B R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 3 | Adult human cytokeratin 19-positive cells recxpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans 显示文摘 | Kerr Conte J Belaich S | 2000 | Diabetes2000，49，10： | 1 |
| 4 | The effects of admission alcohol level on cerebral blood flow and outcomes after severe traumatic brain injury显示文摘 | Alexander S Kerr ME Yonas H | 2004 | J Neurotrauma2004，21，5： | 1 |
| 5 | Roles of epithelial cell derived periostin in TGF beta activa- tion,collagen production, and collagen gel elasticity in asthma显示文摘 | Sidhu S S Yuan S Innes A L Kerr S Woodruff P G Hou L | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 6 | Characterization of diurnal changes in activity of enzymes involved in sucrose biosynthesis显示文摘 | THOMAS W R JRPHILLIP S KERR HUBER S C | 1983 | Plant Physiol1983，73，： | 1 |
| 7 | Biochemical and molecular characterization of a mutation that confers a decreased raffinosaccharide and phytic acid phenotype on soybean seeds 显示文摘 | Hize W D Carlson T J Kerr P S Sebastian S A | 2002 | Plant Physiology2002，128，： | 1 |
| 8 | A comparison of diabetes care quality in the veterans health care system and commercial managed care显示文摘 | Kerr E Gerzoff R Krein S | 2004 | Annals of Internal Medicine2004，141，4： | 1 |
| 9 | Controlled Clinical Trial of Dichloroacetate for Treatment of Congenital Lactic Acidosis in Children显示文摘 | Stacpoole P W Kerr D S Barnes C | 2006 | Pediatrics2006，117，15： | 1 |
| 10 | Delaying surgery after neoad-juvant chemoradiotherapy for rectal cancer may reduce postoperative morbidity without compromising prognosis显示文摘 | Kerr SF Norton S Glynne-Jones R | 2008 | Br J Surg2008，95，12： | 1 |
| 11 | Wound healing dressings and drug delivery systems: A review显示文摘 | Joshua S B Kerr H M Howard N E S | 2008 | J Pharma- ceutical Sci2008，97，8： | 1 |
| 12 | Autonomic function is impaired in elderly stroke survivors 显示文摘 | McLaren A Kerr S Allan L | 2005 | Stroke2005，36，5： | 1 |
| 13 | Moving mass trim control for aerospace vehicles显示文摘 | Sturgis B R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 14 | Manure composition of swine as affected by dietary protein and cellulose concentrations显示文摘 | Kerr B J Ziemer C J Trabue S L | 2006 | Journal of Animal Science2006，84，6： | 1 |
| 15 | Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart显示文摘 | HALESTRAP AP KERR PM JAVADOV S | 1998 | Biochim Biophys Acta1998，1366，12： | 1 |
| 16 | Moving mass trim control for aerospace vehicles显示文摘 | Robinett III R D Sturgis R R and Kerr S A | 1996 | Journal of Guidance Control and Dynamics1996，19，5： | 1 |
| 17 | Tradable carbon permit auctionshow and why to auction not grandfather 显示文摘 | Cramton P Kerr S | 2002 | Energy Policy2002，30，4： | 1 |
| 18 | Aerobic and anaerobic swimming performance of individual Atlantic Cod 显示文摘 | Reidy S P Kerr S R Nelson J A | 2002 | Journal of Experimental Biology2002，203，2： | 1 |
| 19 | Tradeable carbon permit auctiors-how and why to auction not grandfather显示文摘 | CRAMTON P KERR S | | 0，，04： | 1 |
| 20 | Monitoring Vege- tation Cover Across Semi - arid Regions: Comparison of Re- mote Observations From Various Scales 显示文摘 | Leprieur C Kerr Y H Mastorchio S | 2000 | INT J REMOTE SENS2000，21，2： | 1 |
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