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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Electrochemical characterisation of the porosity and corrosion resistance of electrochemically deposited metal coatings显示文摘 | F.C. Walsh C. Ponce de León C. Kerr S. Court B.D. Barker | 2008 | Surface & Coatings Technology2008，，： | 1 |
| 3 | Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice 显示文摘 | Kerr DE Plaut K Bramley A J | 2001 | Nature Biotech:2001，19，1： | 1 |
| 4 | Randomized phase Ⅲ trial of docetaxel versus vinorebine or ifosfamide in patients with advanced non-small cell lung cancer previously treated with platinum containing chemotherapy regimens 显示文摘 | Fossella F de Vore R Kerr RN | 2000 | J Clin Oncol2000，18，12： | 1 |
| 5 | The fundamentals of fuzzy mathmatical morphology, part 2 : idempotence, convexity and decomposition 显示文摘 | de Bates B Kerre E Gupta M | 2001 | Int J CeneraL Systems2001，23，： | 1 |
| 6 | The impact of standard high - flux polysulfone versus novel high - flux polysulfone dialysis membranes on inflammatory markers: a randomized,single-blinded,controlled clinical trial显示文摘 | Kerr PG Sutherland WH de Jong S | 2007 | Am J Kidney Dis2007，49，： | 1 |
| 7 | Fuzzy preference structures without incomparability显示文摘 | De Baets B Van de Walle B Kerre E | 1995 | Fuzzy Sets and Systems1995，76，： | 1 |
| 8 | Flexible and deployable meteoroid/debris shielding forspacecraft显示文摘 | Christansen E L Kerr J H De La Fuente H M | 1999 | International Journal of Impact Engineering1999，23，1： | 1 |
| 9 | Lysostaphin expression in mammary glands corders protection against staphylococcal infection in transgenic mice显示文摘 | pLAuT K BRAMLEY AJ | 2001 | Nature Biotech2001，19，1： | 1 |
| 10 | Regressions and cures ofmelonoma xenografts following treatment with monoclonal antibody- beta- lactamase conjugate in combination with anticancer prodrugs显示文摘 | Kerr DE Schreiber G J Vrudhula VM | 1995 | Cancer Res1995，55，16： | 1 |
| 11 | Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice显示文摘 | PLAuT K BRAMLEY AJ | 2001 | Nat Biotechnol2001，，19： | 1 |
| 12 | Fuzzy Preference Structures Without Incomparability 显示文摘 | De Baets B De Walle B V Kerre E | 1995 | Fuzzy Sets and Systems1995，76，： | 1 |
| 13 | Alterations of the fine structure and androgen secretion of interstitial cells in the experimentally cryptorchid rat testis显示文摘 | Kerr JB Rich KA De Kretser DM | 1979 | Biol Reprod1979，20，3： | 1 |
| 14 | Ample fields as a basis for possibilitie processes显示文摘 | Janssen H J Cooman G De Kerre E E | 2001 | Fuzzy Sets and Systems2001，120，： | 1 |
| 15 | Fuzzy relations and applications显示文摘 | De Baets B Kerre E E | 1994 | Advances in Electronics and Electron Physics1994，89，： | 1 |
| 16 | Fuzzy preference structures without incomparability显示文摘 | De Baets B Van de Walle B Kerre E | 1995 | Fuzzy Sets and Systems1995，76，： | 1 |
| 17 | Randonmized phase Ⅲ trail of doeetaxel vergus vinorelbine or ifoshmidein patients with advanced non-smaU cell lung cancer previously treated with platinum-containing chemotherapy reg-imens显示文摘 | Fossella F V De Vore R Kerr R N | 2000 | J Clin Oncol2000，18，： | 1 |
| 18 | On (un)suitable fuzzy relations to model approximate equality显示文摘 | De Cock M Kerre E E | 2003 | Fuzzy Sets and Systems2003，133，2： | 1 |
| 19 | A fuzzy impulse noise detection and reduction method显示文摘 | Stefan Schulte Mike Nachtegael Valerie De Witte Dietrich Van der Weken Etienne Kerre | 2006 | IEEE Trans on Image Processing2006，15，5： | 1 |
| 20 | Fuzzy preferences without incomparubilir y显示文摘 | Dc Baets 13 Van de Walle B Kerre E | 1995 | 76: 333- 3481995，76，： | 1 |
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