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| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | Sensitive Detection of Cold Cesium Molecules Formed on Feshbach Resonances显示文摘 | CHIN C VULETIC V KERMAN A J | 2003 | Phys Rev Lett2003，90，03： | 1 |
| 3 | High-Energy Backward Elastic Proton-Deuteron Scattering and Baryon Resonances显示文摘 | Kerman A K Kisslinger L S | 1969 | Phys Rev1969，180，： | 1 |
| 4 | Methylene Blue as a Novel Electrochemical Hybridization Indicator显示文摘 | Erdem A Kerman K Meric B | 2001 | Eleetroanal2001，13，3： | 1 |
| 5 | Novel hybridization indicator methylene blue for the electrochemical detection of short DNA sequences related to the hepatitis B virus显示文摘 | Erdem A Kerman K Meric B | | 0，，： | 1 |
| 6 | The scattering of fast nucleons from nuclei显示文摘 | KERMAN A K McMANUS H THALER R M | 1959 | Ann Phys1959，8，： | 1 |
| 7 | Clinical experience and incidence pneumonia using closed versus open suction- system显示文摘 | kerman E Larsson C Ersson A | 2014 | Nurs Crit Care2014，19，： | 1 |
| 8 | Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas显示文摘 | Carneiro A Bendahl PO (A)kerman M | 2011 | J Clin Pathol2011，64，8： | 1 |
| 9 | Impossible 'mental rotation' problems A mismeasure of women's spatial abilities? 显示文摘 | Kerman D D Wise J C Elizabeth A Harwood | 2000 | Learning and Individual Differences2000，，9： | 1 |
| 10 | Beyond Optical Molasses:3D Raman Sideband Cooling of Atomic Cesium to High Phase-Space Density显示文摘 | KERMAN A J VULETIC V CHEN C | 2000 | Phys Rev Lett2000，84，： | 1 |
| 11 | Methylene blue as a novel electrochemical hybridization indicator 显示文摘 | Erdem A Kerman K Merie B | 2001 | E- lectroanalysis2001，13，3： | 1 |
| 12 | Role of metal ions in ligand receptor interaction:insights from structural studies显示文摘 | Ananthanarayanan V.S Kerman A | | 0，，1： | 1 |
| 13 | Carbon dioxide corrosion in oil gas production --A compendium critical review of corrosion science and engineering显示文摘 | KERMAN M B MORSHED A | 2003 | Corrosion2003，59，8： | 1 |
| 14 | Brainstem Substrates of Sympatho-motor Circuitry Identified Using Trans-synaptic Tracing with Pseudorabies Virus Recombinants 显示文摘 | KERMAN I A ENQUIST L W WATSON S J | 2003 | Neuroscience2003，23，11： | 1 |
| 15 | Does melatonin protect or treat brain damage from traumatic oxidative stress显示文摘 | Kerman M Cirak B Ozguner MF Dagtekin A Sutcu R Altuntas I Delibas N | | 0，，： | 1 |
| 16 | Carbon dioxide corrosion in oil gas production-a compendium critical review of corrosion science and engineering显示文摘 | Kerman M B Morshed A | 2003 | Corrosion2003，59，8： | 1 |
| 17 | 781 Mbit/s photon-counting optical communication using a superconducting nanowire detector显示文摘 | Bryan S Robinson Andrew J Kerman Eric A Dauler | | 0，，04： | 1 |
| 18 | The rhizosphere and PAH amendment mediate impacts on functional and structural bacterial diversity in sandy peat soil显示文摘 | YRJ(A)L(A) K KESKINEN A K (A)KERMAN M L | 2010 | Environmental Pollution2010，158，5： | 1 |
| 19 | Carbon Dioxide Corrosion in Oil and Gas Production-A Compendium 显示文摘 | KERMAN! M B MORSHED A | 2003 | Corrosion2003，59，08： | 1 |
| 20 | Gut microbiota and inflammatory bowel disease:the role of antibiotics in disease management 显示文摘 | KERMAN D H DESHPANDE A R | 2014 | Postgraduate Medicine2014，126，4： | 1 |
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