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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 4 | COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention 显示文摘 | Mary C C Kenneth J O John V R | 2012 | Biochim Biophys Acta2012，1825，1： | 1 |
| 5 | Pericentral Hepatic Fibrosis and Intracellular Hyalin in Diabetes Mellitus显示文摘 | Kenneth R F alchuk Steven C | 1980 | Gastroente rology1980，78，： | 1 |
| 6 | Late relapses in patients successfully treated for thrombotic thrembocytopenic purpura显示文摘 | Kenneth H S Gail A R Rama C | 1995 | Ann Intern Med1995，122，8： | 1 |
| 7 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 8 | A survey of research in the application of tolerance analysis to the design of mechanical assemblies显示文摘 | KENNETH W C ALAN R P | 1991 | Research in Engineering Design1991，3，11： | 1 |
| 9 | Modeling thermally thick pyrolysis of wood 显示文摘 | KENNETH M B KENNETH W R RUTLAND C J | 2002 | Biomass and Bioenergy2002，22，： | 1 |
| 10 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 11 | Technetium-99m galactosyl-neoglycoalbumin: preparation and preclinical studies显示文摘 | David R Robert C Kenneth A | 1985 | J Nucl Med1985，26，10： | 1 |
| 12 | Mandatory steroid testing of high school athletes:A synthesis of state ini- tiatives and federal constitutional rights显示文摘 | KENNETH J S KEITH M C SHANTEL R K | 2012 | J Legal Aspects Sport2012，，21： | 1 |
| 13 | Wnt/β-catenin Signaling in Normal and Cancer Stem Cells显示文摘 | Kenneth C Valkenburg Carrie R Graveel Cassandra R Zylstra-Diegel | 2011 | Cancers2011，3，： | 1 |
| 14 | Practical guide to the diagnosis of thalassemia显示文摘 | Kenneth WD Boehm C James R | 1996 | Am J M Genetics1996，62，： | 1 |
| 15 | Determination of ammonia based on the electro-oxidation of hydroquinone in dimethylformamide or in the room temperature ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide显示文摘 | Debora Giovanelli Marisa C Buzzeo Nathan S Lawrence Christopher Hardacre Kenneth R Seddon Richard G Compton | 2003 | Talanta2003，，： | 1 |
| 16 | Accurate (PρT) data for methane from (300 to 450) K up to 180 MPa显示文摘 | Diego E C Ivan D M Kenneth R H | 2010 | Chemical Engineer Data2010，55，： | 1 |
| 17 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 18 | Practical guide to the di- agnosis of thalassemia显示文摘 | Kenneth WD Boehm C James R | 1996 | Am J M Genetics1996，62，1： | 1 |
| 19 | The effective and environmental half-life of ^137Cs at Coral Islands at the former US nuclear test site显示文摘 | William L R Cynthia L C Kenneth T B | 2003 | Journal of Environmental Radioactivity2003，69，： | 1 |
| 20 | NOSH-aspirin( NBS- 1120 ), a novel nitric oxide-and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth < i > in vitro and in a xenograft mouse model显示文摘 | MITALI C RAVINDER K KENNETH R O | 2012 | Biochemical and Bio- physical Research Communications2012，419，3： | 1 |
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