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| 1 | 儿童期应用吸入性糖皮质激素治疗对成年身高的影响显示文摘背景在青春期前儿童中,应用吸入性糖皮质激素治疗持续性哮喘可引起生长速度暂时减慢。目前认为开始吸入性糖皮质激素治疗后1~4年所致的身高降低不会降低成年后所达到的身高。方法在儿童哮喘管理计划(试验)的1 041名受试者中,我们测量了943名(90.6%)受试者的成年身高,测量成年身高时的平均年龄为(24.9±2.7)岁。从5~13岁时开始,受试者被随机分配接受每日布地奈德400μg、奈多罗米16 mg或者安慰剂治疗4~6年。我们采用对(受试者在)试验入选时人口学特性、哮喘特点以及身高进行校正的多因素线性回归方法,计算了每个治疗组的成年身高(分别)与安慰剂组相比的差异。结果布地奈德组成年平均身高较安慰剂组低1.2 cm〔95%CI(-1.9,-0.5)〕,奈多罗米组成年平均身高较安慰剂组低0.2cm〔95%CI(-0.9,0.5),P=0.61〕。最初2年内吸入性糖皮质激素的日剂量较大,与成年身高较低相关(剂量每增大1 mg/kg体质量,身高就降低0.1 cm,P=0.007)。布地奈德组与安慰剂组相比成年身高降低与治疗了2年后的身高降低情况相似〔-1.3 cm,95%CI(-1.7,-0.9)〕。在最初的2年内,布地奈德组的生长速度减慢主要发生在青春期前的受试者中。结论青春期前儿童中最初出现的、与应用吸入性糖皮质激素治疗相关的身高降低在成年时仍持续存在,不过身高的降低不是进行性的,也不具有累积性。 | Kelly HW Sternberg AL Lescher R | 2012 | 中国全科医学2012，15，36： | 9 |
| 2 | Overview of recent advances in metastatic triple negative breast cancer显示文摘Metastatic triple negative breast cancer(TNBC)has an aggressive phenotype with a predilection for visceral organs and brain.Best responses to chemotherapy are predominately in the first line.Recent studies have demonstrated improved progression free survival with the combination of atezolizumab/pembrolizumab and chemotherapy in programmed death-ligand 1 positive metastatic TNBC.However,a recent trial in a similar population showed no benefit for atezolizumab and paclitaxel which led to a Food and Drug Administration alert.Two phase III trials(OLYMPIAD and BROCADE3)demonstrated a benefit in progression free survival(PFS)but not overall survival in patients with BRCAassociated metastatic TNBC treated with Olaparib or Talazoparib respectively.For those treated with Talazoparib,the time to deterioration in health related-quality of life was also longer compared to chemotherapy.The BROCADE3 trial demonstrated that the combination of a platinum and veliparib increased PFS in first-line metastatic TNBC but at the cost of increased toxicity.There are no headto-head comparisons of a poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)and platinums.There are unanswered questions regarding the role of PARPi maintenance after platinum therapy as is standard of care in BRCAassociated ovarian cancer.Other areas of therapeutic interest include targeting aberrations in the phosphoinositide 3-kinase pathway,protein kinase B,mammalian target of rapamycin or utilising antibody drug conjugates.This review focusses on recent and emerging therapeutic options in metastatic TNBC.We searched PubMed,clinicaltrials.gov and recent international meetings from American Society of Clinical Oncology,San Antonio Breast Cancer Conference and the European Society of Medical Oncology. | David O'Reilly Maha Al Sendi Catherine M Kelly | 2021 | World Journal of Clinical Oncology2021，12，3： | 5 |
| 3 | Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease显示文摘AIM To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel diseases.METHODS We recruited adolescents and young adults(AYA) with inflammatory bowel diseases(IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRx ANSITION Scale? at least once during the study period(2006-2015). We used the electronic medical record to extract participants' clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition readiness.RESULTS Our sample(n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRx ANSITION Scale? scores(P < 0.01). Many healthcare transition(HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management skills.CONCLUSION This is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions. | Natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts Eniko Rak Maureen Kelly Sandra Kim Miranda AL van Tilburg | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 4 | Pain assessment for children: overcoming challenges and optimizing care 显示文摘 | Ndel AL Kelly BT Samina A | 2011 | Pediatr Emerg Care2011，27，8： | 1 |
| 5 | The intention of advanced prac- tice registered nurses to remain in positions at family planning clinics serving low-income women显示文摘 | Cheng AL Kelly P J Carlson K | 2014 | J Prof Nurs2014，30，1： | 1 |
| 6 | High-pressure- homogenised cream liqueurs: Emulsification and stabilization efficiency 显示文摘 | Heffernan S P Kelly AL Mulvihill D M | 2009 | Journal of Food Engineering2009，95，： | 1 |
| 7 | Pedicle Subtraction Osteotomy in the Cervical Spine显示文摘 | Wollowick AL Kelly MP Riew KD | 2012 | Spine2012，37，5： | 1 |
| 8 | Antitumor activity ofsuberoylanilide hydroxamic acid against thyroid cancer cell lines invitro and in vivo显示文摘 | Luong QT 0/Kelly J Braunstein GD ei al | 2006 | Clin Cancer Res2006，12，18： | 1 |
| 9 | Novel insights on interactions between folate and lipid metabolism显示文摘 | Robin P. Silva Karen B. Kelly Ala Al Rajabi René L. Jacobs | 2014 | BioFactors2014，，3： | 1 |
| 10 | Kinetics of changes in plasmin activity and proteolysis on heating milk显示文摘 | Crudden A Oliveira JC Kelly AL | | 0，，04： | 1 |
| 11 | The role of systemic inflammatory biomarkers to predict mortality in chronic obstructive pulmonary disease显示文摘 | Kelly E Owen CA Pinto-Plata V et ' al | 2013 | Expert Rev Respir Med2013，7，1： | 1 |
| 12 | Turpie AG Prophylaxis of venous thromboembolism in stroke patients显示文摘 | Kelly J Rudd A Lewis RR e al | 1997 | Semin Thromb Hemost1997，23，2： | 1 |
| 13 | Effect of in- haled glucocorticoids in childhood on adult height显示文摘 | Kelly HW Sternberg AL Lescher R | 2012 | N Engl J Med2012，367，10： | 1 |
| 14 | The past and presentthreat of rickettsial diseases to military medicine and internationalpublic health显示文摘 | Kelly DJ Richards AL Temenak J | 2002 | Clin Infect Dis2002，34，4： | 1 |
| 15 | Expression of HLA-DR antigegent on bile duct epithelium in primary sclerosing cholangitis显示文摘 | Chapman RW Kelly PMA Heryrt A et al | 1988 | Gut1988，29，4： | 1 |
| 16 | Evidence - based nursing: Making changes in the clinical practice through the collaboration of nursing students and practicing nurses 显示文摘 | Kelly EK Hunley AL Wegner JL | 2005 | Appl Nuts Res2005，18，4： | 1 |
| 17 | xylA cloning andsequencing and biochemical characterization of xylose isomerasefrom Thermotoga neapolitana显示文摘 | Vieille C Hess J M Kelly R M al | 1995 | Appl Environ Microbiol1995，61，5： | 1 |
| 18 | Inhaled corticosteroids in children: effects on bone mineral density and growth 显示文摘 | Fuhlbrigge AL Kelly HW | 2014 | Lancet Respir Med2014，2，6： | 1 |
| 19 | Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke显示文摘 | Han HS Karabiyikoglu M Kelly S et al | 2003 | J Cereb Blood Flow Metab2003，23，： | 1 |
| 20 | Distinguishing between ad- justment disorder and depressive episode in clinical practice: The role of personality disorder 显示文摘 | Doherty AM Jabbar F Kelly BD ct al | 2014 | J Affect Disord2014，168，： | 1 |
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