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| 1 | Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia显示文摘AIM To study liver stiffness(LS) during pregnancy and its association with complications during pregnancy.METHODS In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, respectively.RESULTS In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor. | Franziska J Ammon Anna Kohlhaas Omar Elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 2 | 快速演变的三板块边界上的一次大地震破裂显示文摘2007年4月1日,一次大海啸地震(MW8.1)使得所罗门群岛俯冲带在一个三联点处破裂。在这个三联点上,澳大利亚板块、所罗门海-伍德拉克盆地板块在不同滑动方向上同时向太平洋板块俯冲。大地震过程中,相关的滑动方向突变使得太平洋板块上部收敛滞弹性变形,这就产生了Simbo俯冲断层之上弧前的局部隆起,潜在地放大了局地海啸振幅。地震周期过程中的弹性形变似乎主要通过上冲的太平洋弧前来调节。这次地震显示了极其年轻的俯冲大洋岩石圈的孕震潜力和横贯坚实地质边界的破裂能力,也显示了引起隆起和海啸的复杂同震滑动的后果。 | Kevin P Furlong Thorne Lay Charles J Ammon 吴清 | 2010 | 国际地震动态2010，，5： | 2 |
| 3 | The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells显示文摘与正规象 ubiquitin 一样蛋白质不同, Hub1 不形成共有原子价与底层结合,但是 proteinsnon-covalently 绑。在 Saccharomyces cerevisiae, Hub1 与 spliceosomes 联系并且调停,没有影响通常拼接的 pre-mRNA SRC1 的其他的拼接。人的 Hub1 高度类似于它的酵母相当或相同的事物,而是它的细胞的 functionremains 大部分未经勘探。这里,我们证明人的 Hub1 作为在酵母绑在 spliceosomal 蛋白质 Snu66;然而, unlikeits S。cerevisiae 相当或相同的事物,人的 Hub1 为生存能力是必要的。在 Hub1 导致的人的 vivo 弄空延长了各种各样的细胞的缺点,包括拼接的点缀畸形,部分原子 retentionof mRNAs,有丝分裂的大祸,并且因而由 apoptosis 的房间死亡。然而, Hub1 弄空的早后果仅仅是严重 splicingdefects 为特定拼接地点导致 exon 跳过和 intron 保留。因此,象 ubiquitin 一样 proteinHub1 不是为拼接,而是其他的拼接的 spliceosome performanceand facilitator 的一个调节的人通常需要的一个正规 spliceosomal 因素。 | Tim Ammon Shravan Kumar Mishra Kaja Kowalska Grzegorz M. Popowicz Tad A. Holak Stefan Jentsch | 2014 | Journal of Molecular Cell Biology2014，8，4： | 2 |
| 4 | Pharmacology of curcuma longa显示文摘 | Ammon HPT Wahl MA | 1991 | Planta Med1991，57，1： | 1 |
| 5 | Pharmacology of Curcuma longa显示文摘 | Ammon H Wahl M | 1991 | Planta Med1991，57，1： | 1 |
| 6 | Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit Gram-negative sepsis显示文摘 | Lin Y Leach WJ Ammons W S | 1996 | Antimicrob Agents Chemother1996，40，1： | 1 |
| 7 | The Role of Technology in the Shift towards Open Innovation:the Case of Procter & Gamble显示文摘 | Mark Dodgson1 David Gann2 and Ammon Salter | 2006 | R&D Management2006，36，3： | 1 |
| 8 | Monitoring results of the effectiveness of surge arrester spacings on distribution line protection 显示文摘 | SHORT T A AMMON R H | 1999 | IEEE Transactions on Power Delivery1999，14，3： | 1 |
| 9 | Gabapentin enhances the analgesic effect of morphine in healthy volunteers显示文摘 | Eckhardt K Ammon S Hofmann U Riebe A Gugeler N Mikus G | 2000 | Anesth Analg2000，91，： | 1 |
| 10 | Tumours of the limbic and paralimbic systems 显示文摘 | Yasargil MG von Ammon K Cavazos E | 1992 | Acta Neurochir1992，118，： | 1 |
| 11 | Pharmacology of curcuma longa显示文摘 | Ammon HP Wahl MA | 1991 | Planta Med1991，57，： | 1 |
| 12 | Crataegus Toxicology and Pharmacology显示文摘 | AMMON HPT HAENDEL M | 1981 | Planta Med(S0378-8741)1981，43，2： | 1 |
| 13 | Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata 显示文摘 | Ammon HPT Mack T Singh GB | 1991 | Planta Med1991，57，3： | 1 |
| 14 | The economic benefits publicly funded research显示文摘 | Ammon J Salter Ben R Martin | 2000 | Research Policy2000，，30： | 1 |
| 15 | An optimization model for production costing in electronic utilities 显示文摘 | Ammons J C McGinnis L F | 1983 | Management Science1983，29，30： | 1 |
| 16 | A real-time intrusion system based on learning program behavior显示文摘 | Ammons G Bodik R Larus J R | 2002 | ACM SIGPLAN NOTICES2002，，01： | 1 |
| 17 | Randomized trial of warfarin,aspirin,and clopidogrel in patients with chronic heart failure:the Warfarin and Antiplatelet Therapy in Chronic Heart Failure(WATCH)trial显示文摘 | Massie BM Collins JF Ammon SE WATCH Trial Investigators | 2009 | Circulation2009，119，： | 1 |
| 18 | Observing preferential flow paths beneath West Tennessee's loess terrains using ground penetrating radar 显示文摘 | Yoder R E Ammons D T | 1997 | Tennessee Agri Science1997，181，： | 1 |
| 19 | Pharmacology of Curcuma longa显示文摘 | Ammon HPT Wahl MA | 1991 | Planta Med1991，57，： | 1 |
| 20 | Transmission dynamics of the great influenza pandemic of 1918 in Geneva, Switzerland: assessing the effects of hypothetical interventions 显示文摘 | Chowell G Ammon CE Hengartner NW | 2006 | J Theor Biol2006，241，2： | 1 |
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