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| 1 | Early Paleozoic ridge subduction in the Chinese Altai: Insight from the abrupt change in zircon Hf isotopic compositions显示文摘Zircons were separated from granitoids, gneisses, and sedimentary rocks of the Chinese Altai. Those with igneous characteristics yielded U-Pb ages of 280-2800 Ma, recording a long history of magmatic activity in the region. Zircon Hf isotopic compositions show an abrupt change at ~420 Ma, indicating that prior to that time the magmas came from both ancient and juvenile sources, whereas younger magmas were derived mainly from juvenile material. This may imply that the lithosphere was signifi- cantly modified in composition by a rapid addition of melt from the mantle. We suggest that this dramatic change was due to the onset of ridge subduction, which can account not only for the formation of voluminous granitoids, mafic rocks with complex compositions, and the association of adakite + high-Mg andesite + boninite + Nb-enriched basalt, but also for the coeval high-T, low-P metamorphism. | SUN Min LONG XiaoPing CAI KeDa JIANG YingDe WANG BuYun YUAN Chao ZHAO GuoChun XIAO WenJiao WU FuYuan | 2009 | Science China Earth Sciences2009，52，9： | 33 |
| 2 | Enhancement Expression of bFGF in Chinese Patients with Moyamoya Disease显示文摘Objective To detect the content of the basic fibroblast growth factor in blood samples of patients with Moyamoya disease, and investigate the relationship between Moyamoya disease and the basic fibroblast growth factor. Methods This tissue microarray study included 24 cases of superficial temporal artery samples, 15 cases of Moyamoya disease, and 9 cases of normal arteries as control, and bFGF immunofluorescence assay was applied to test the samples. The number of positive cells and total cells of the muscular layer and the endothelium layer were counted separately in every picture, the positive rates were calculated, and the experimental data were analyzed statistically. Results The bFGF immunofluorescence staining of smooth muscular layer cells, intima cells and endothelial cells from the moyamoya disease group were obviously stronger than that from the control group (P<0.01). Conclusion The enhancement expression of bFGF in the Moyamaya disease group implicates that bFGF plays an important part in the pathogenesis of Moyamoya disease. | ZOU DeWei ZHAO JiZong ZHANG Dong WANG Shuo WANG KeDa ZHANG Yan | 2011 | Biomedical and Environmental Sciences2011，24，1： | 12 |
| 3 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 4 | 持续血液滤过及内毒素吸附治疗外科感染性多器官衰竭(英文)显示文摘目的 :探索持续血液滤过及内毒素直接吸附治疗外科感染性多器官衰竭的有效性。方法 :为 1例外科感染性多器官衰竭患者进行血液持续滤过 ,并利用多粘菌素B结合纤维 (PMX)进行内毒素吸附。PMX治疗每 2 /d ,共 8d。结果 :用上述方法治疗后 ,内毒素和IL 6水平下降 ,病情好转并停用血管活性药物。结论 :持续血液滤过并用PMX吸附内毒素是治疗外科感染性多器官衰竭的有效方法。 | Naoto Matsuno ToshiakiI keda Takeshi Nagao | 2001 | 河南医科大学学报2001，36，3： | 4 |
| 5 | Multi-Method Chronometric Constraints on the Thermal Evolution of the Central Tianshan,NW China显示文摘The Tianshan orogenic belt is a major part of the southern Central Asian Orogenic Belt(CAOB),extending from west to east for over 2500 km through Uzbekistan,Tajikistan,Kyrgyzstan and Kazakhstan to Xinjiang in NW China,and contains the record of multi-phase tectonothermal evolution.Till now,various research methods have been employed to reveal the | YIN Jiyuan CHEN Wen XIAO Wenjiao ZHANG Bin CAI Keda | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 4 |
| 6 | Theoretical study on rotary-sliding disk triboelectric nanogenerators in contact and non-contact modes显示文摘摩擦电 nanogenerator (TENG ) 作为收获技术的一个新、有效的机械精力出现了。在这个工作,为有栅栏结构的旋转滑动的磁盘 TENG 的一个理论模型被构造,包括 dielectric-to-dielectric 和 conductor-to-dielectric 盒子。有限元素方法(女性) 被利用描绘在接触和非接触模式工作的 rotarysliding 磁盘 TENG 的基本物理。磁盘 TENG 的基本性质被发现被象 tribo 表面间距,栅栏数字,和几何尺寸那样的结构的参数控制。从女性的计算,一种近似 V-Q- 关系通过插值方法被造,然后有任意的负担抵抗的 TENG 动态产量特征是数字地计算的。最后,结构的参数和旋转上的力量和匹配的抵抗评估的输出的相关性被揭示。现在的工作提供旋转滑动的磁盘 TENG 的工作原则的深入的理解并且为在特定的应用程序优化 TENG 输出性能用作重要指导。 | Tao Jiang Xiangyu Chen Keda Yang Changbao Han Wei Tang Zhong Lin Wang | 2016 | Nano Research2016，9，4： | 3 |
| 7 | The advance of adjuvant treatment for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a subtype of breast cancer characterized by its highly aggressive behavior,early recurrence,and poor outcomes,when compared with other subtypes.Due to the absence of the estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2 expression,TNBC lacks meaningful biomarkers and an effective therapeutic strategy.Chemotherapy remains the main adjuvant treatment for patients with TNBC.Anthracycline/taxane-based regimens are the standard of care in adjuvant settings.The addition of capecitabine or platinum may offer extra benefits to patients with TNBC,but at the cost of increased toxicity or adverse events.Dose-dense chemotherapy may enhance treatment efficacy in patients who are able to tolerate the treatment regimen,especially in high-risk patients.As a heterogenous disease,TNBC can be classified into several molecular subtypes according to genomic or transcriptional features,which may indicate potential targets for more precise and individualized treatment strategies.With our increased understanding of signal pathways associated with TNBC,as well as the discovery of novel biomarkers indicative of TNBC prognosis,several new therapeutic options are under investigation,and some have already reported good results.In this review,we summarized the current conventional therapeutic strategies and emerging clinical trials regarding adjuvant treatment for TNBC.Furthermore,we evaluated the prognostic value of several potential targets and the progress of targeted therapy in TNBC,both in neoadjuvant and adjuvant settings. | Jingyu Ge Wenjia Zuo Yiyu Chen Zhiming Shao Keda Yu | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
| 8 | Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy显示文摘 | Yamamoto J Kinoshita M | 2006 | Seizure2006，15，： | 1 |
| 9 | Nuclear factor kB(NF-xB) activation by hydrogen peroxide in human epidermal keratino- cytes and the restorative effect of interleukin-10显示文摘 | Keda M Hirose Y Miyoshi K | 2002 | Dermatoi Sci2002，2，： | 1 |
| 10 | The effects of dietary calcium and protein intake on changes in bone mineral density during early and late stages of pregnancy 显示文摘 | ~oneyama K | 2010 | Nippon Koshu Eisei Zasshi2010，57，10： | 1 |
| 11 | Varions application of vesonant pressure sensor chip based on 3 -D micromachining显示文摘 | Kinji Harada Kyoichi Keda | 1999 | Sensors and Actuators1999，73，： | 1 |
| 12 | Involvement of proteolytic enzymes in the lipotropic effect of the pituitary polypeptide hormones显示文摘 | Pankov YA Keda YM Sazina ET | 1986 | Horm Metab Res1986，18，6： | 1 |
| 13 | New protection method for HVDC lines including cables显示文摘 | TA KEDA H A YAKAWA H TSUMENA GA M | 1995 | IEEE Trans on Power Delivery1995，10，4： | 1 |
| 14 | Effects of maturational age of porcine oocytes on the induction of activation and development in vitro following somatic cell nuclear transfer显示文摘 | Keda I Takahashi Y | | 0，，： | 1 |
| 15 | Structural phase transformation and UV-vis characterization of Cr^3+ doped nanosized titanium dioxide显示文摘 | Keda Toshitatsu | 2008 | American Chemical Society2008，112，4： | 1 |
| 16 | Increased solube form of P selectin in patients with unstable angina显示文摘 | I Keda H Mansour M RothleinR | 1995 | Circulation1995，92，： | 1 |
| 17 | Impact of dialysis therapy on insulin resistance in end - stage renal disease comparison of haermodialysis and continuous ambulatory peritioneal dialysis显示文摘 | Kobayashi S Macjimas I Keda T | 2000 | Nephrol Dial Transplant2000，15，1： | 1 |
| 18 | Production Of aldosterone in isolated rat blood vessels显示文摘 | Ta keda Y Miyamorl I YOneda T | 1995 | Hypemntion1995，25，2： | 1 |
| 19 | Frequent occur-rence of apoptosis in an early event in the ontogenesis of human gastric carcinoma 显示文摘 | L Keda M Shomori K Endo K | 1998 | Virchows At1998，32，1： | 1 |
| 20 | Feline host range of canine parvovirus: recent emergence of new antigenic type types in cats 显示文摘 | Keda Y Nakamura K Miyazawa T | 2002 | Emerg Infect Dis2002，8，4： | 1 |
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