|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resistance to conventional chemotherapies. Kras mutation is a well-defined hallmark of pancreatic cancer, with over 95% of cases harbouring Kras mutations that give rise to constitutively active forms of Kras. As important down-stream effectors of Kras, p21-activated kinases(PAKs) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance. Immunotherapy is now emerging as a promising treatment modality in the era of personalized anti-cancer therapeutics. In this review, basic knowledge of PAK structure and regulation is briefly summarised and the pivotal role of PAKs in Kras-driven pancreatic cancer is highlighted in terms of tumour biology and chemoresistance. Finally, the involvement of PAKs in immune modulation in the tumour microenvironment is discussed and the potential advantages of targeting PAKs are explored. | Kai Wang Graham S Baldwin Mehrdad Nikfarjam Hong He | 2018 | World Journal of Gastroenterology2018，24，33： | 7 |
| 2 | PELIMINARY ANALYSES FOR CROP WATER CONSUMPTION BY USING LYSIMETER显示文摘This paper deliberates on the issue of water consumption (evapotranspiration, ET) of three main crops in North China: wheat, corn and bean, which is mainly related to three factors as indicated by the definition of SPAC system. Water consumption was measured on daily and sometimes hourly basis by Lysimeter, which can be adjusted to have the same groundwater level as that in the field, thus the measurement could serve as representative of crop water consumption for adjacent area. The consumption period for three crops has been analyzed and cumulative deviation from the mean of daily evapotranspiration been used to divide the whole growing period into several parts, which are related to but different from the growing periods. The serial correlation coefficients for varied lag time have been calculated to verify that the process of daily ET is not random, and therefore the cumulative daily consumption has been simulated by polynomial method, which gives relative good results. Finally, the effort has been made to investigate the relation of crop yield and water consumption and water use efficiency based on a time series of seven years. | Chen Jianyao Wu Kai Institute of Geography, CAS, Beijing 10010 People’s Republic of China | 1997 | Journal of Geographical Sciences1997，7，3： | 6 |
| 3 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 4 | Time delay compensation in active closed-loop structural control显示文摘 | Kai Q J S Kuand | 1995 | Mechanics Research Communications1995，22，2： | 2 |
| 5 | Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct 显示文摘 | Necula M Kayed R Milton S | 2007 | J Biol Chem2007，282，10： | 1 |
| 6 | Identification and characterization of a novel human type Ⅱ diacylglycerol kinase, DGKK显示文摘 | Imai S Kai M Yasuda S | 2005 | Journal of Biological Chemistry2005，280，39： | 1 |
| 7 | Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines显示文摘 | Kai K D'Costa S Sills RC | | 0，，1： | 1 |
| 8 | Source and tectonic implications of tonalite-trondhjemite magmatism in the Klarnath Mountains 显示文摘 | Barnes C G Petersen S W Kistler R W Murray R Kays M A | 1996 | Contrib Mineral Petrol1996，123，1： | 1 |
| 9 | Rapid uptake of 15N-ammonium and glycine- 13C, 15N by arbuscular and ericoid mycorrhizal plants native to a Northern California coastal pygmy forest显示文摘 | Kai C R Caroline S 13 | 2007 | Soil Biology and Biochemistry2007，39，10： | 1 |
| 10 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 11 | Surgical indications to maintain quality of life in elderly patients with ruptured intracranial aneurysms显示文摘 | YANO S HAMADA J KAI Y | 2003 | Neurosurgery2003，52，5： | 1 |
| 12 | Elastic modulus of single cellulose microfibrils from tunicate measured by atomic force microscopy 显示文摘 | lwamoto S Kai W Isogai A | 2009 | Biomacromolecules2009，10，9： | 1 |
| 13 | Inhibition of photosynthesis by ethylene-a stomatal effect显示文摘 | James E Pallas J R Kays S J | 1982 | Plant Physiology1982，70，2： | 1 |
| 14 | Autoregulation of microRNA biogenesis by let-7 and Argonaute显示文摘 | Zisoulis D G Kai Z S Chang R K | 2012 | Nature2012，486，7404： | 1 |
| 15 | Feasibility of laparoscopic py- loromyotomy under spinal anesthesia 显示文摘 | Islam S Larson SD Kays DW | 2014 | J Pediatr Surg2014，49，10： | 1 |
| 16 | Anterior eruciate ligament recon- struction with LARS artificial ligament: a multicenter study with 3 to 5 year follow-up显示文摘 | Kai G Chen S Wang L | 2010 | Arthroscopy2010，26，4： | 1 |
| 17 | Studies on the optimization of stem hull form based on a potential flow solver 显示文摘 | SUZUKI K Z KAI H S KASHIWABARA S T | 2005 | Marine Science and Technology2005，10，： | 1 |
| 18 | Dielectric spectroscopy of honeydew melons from 10 MHz to 118 GHz for quality sensing显示文摘 | Nelson S O Trabelsi S Kays S J | 2006 | Transactions of the ASABE2006，49，6： | 1 |
| 19 | Synthesis and evaluation of a ruthenium-copper oxide/silica catalyst derived from microemulsion processing显示文摘 | Zhang Kai Chew C Kawi S | 2000 | Catal Lett2000，64，24： | 1 |
| 20 | Characterization of biomass-based flash pyrolysis oils显示文摘 | Kai Sioila Eeva Kcoppala Leena Fagerna s | 1998 | BiomassandBioenergy1998，14，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员