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| 1 | Genetics of acute and chronic pancreatitis: An update显示文摘Progress made in identifying the genetic susceptibility underlying acute and chronic pancreatitis has benefitted the clinicians in understanding the pathogenesis of the disease in a better way. The identification of mutations in cationic trypsinogen gene(PRSS1 gene; functional gain mutations) and serine protease inhibitor kazal type 1(SPINK1 gene; functional loss mutations) and other potential susceptibility factors in genes that play an important role in the pancreatic secretory functions or response to inflammation during pancreatic injury has changed the current concepts and understanding of a complex multifactorial disease like pancreatitis. An indi-vidual's susceptibility to the disease is governed by ge-netic factors in combination with environmental factors. Candidate gene and genetic linkage studies have iden-tified polymorphisms in cationic trypsinogen(PRSS1), SPINK1, cystic fibrosis trans-membrane conductance regulator(CFTR), Chymotrypsinogen C(CTRC), Ca-thepsin B(CTSB) and calcium sensing receptor(CASR). Individuals with polymorphisms in the mentioned genes and other as yet identified genes are at an enhanced risk for the disease. Recently, polymorphisms in genes other than those involved in 'intra-pancreatic trypsin regulatory mechanism' namely Claudin-2(CLDN2) andCarboxypeptidase A1(CPA1) gene have also been iden-tified for their association with pancreatitis. With ever growing number of studies trying to identify the genetic susceptibility in the form of single nucleotide polymor-phisms, this review is an attempt to compile the avail-able information on the topic. | VV Ravi Kanth D Nageshwar Reddy | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 7 |
| 2 | Pooled genetic analysis in ultrasound measured non-alcoholic fatty liver disease in Indian subjects:A pilot study显示文摘AIM: To investigate genetic susceptibility in Indian subjects with non-alcoholic fatty liver disease(NAFLD) by performing a pooled genetic study.METHODS: Study subjects(n = 306) were recruited and categorized into NAFLD and control groups based on ultrasound findings of fatty infiltration. Of the 306 individuals, 156 individuals had fatty infiltration and thus comprised the NAFLD group. One hundred and fifty(n = 150) individuals were normal, without fatty infiltration of the liver, comprising the control group. Blood samples, demographic and anthropometric data from the individuals were collected after obtaining informed consent. Anthropometric data, blood glucose, lipids and liver function tests were estimated using standard methods. Genome wide association stud-ies done to date on NAFLD were identified, 19 single nucleotide polymorphisms(SNPs) were selected from these studies that were reported to be significantly associated with NAFLD and genotyping was performed on the Sequenom platform. Student's t test for continuous variables and χ2 test was applied to variant carriers from both groups. Required corrections were applied as multiple testing was done.RESULTS The mean age of the control group was 39.78 ± 10.83 and the NAFLD group was 36.63 ± 8.20 years. The waist circumference of males and females in the control and NAFLD groups were 80.13 ± 10.35; 81.77 ± 13.65 and 94.09 ± 10.53; 92.53 ± 8.27 respectively. The mean triglyceride and alanine transaminase(ALT) levels in the control and NAFLD groups were 135.18 ± 7.77; 25.39 ± 14.73 and 184.40 ± 84.31; 110.20 ± 67.05 respectively. When χ2 test was applied to the number of individuals carrying the variant risk alleles between the control and NAFLD group, a significant association was seen between rs738409 of the patatin-like phospholipase domain containing 3(PNPLA3) gene(P = 0.001), rs2073080 of the PARVB gene(P = 0.02), rs2143571 of SAMM50 gene(P = 0.05) and rs6487679 of the pregnancy zone protein(PZP) gene(P = 0.01) with the disease. Variant single nucleotide polymorphisms(SNPs) in NCAN and PNPLA3 gene were associated with higher levels of ALT, whereas variant SNPs in APOC3, PNPLA3, EFCAB4 B and COL13A1 were associated with high triglyceride levels. Apart from the above associations, rs2073080, rs343062 and rs6591182 were significantly associated with high BMI; rs2854117 and rs738409 with high triglyceride levels; and rs2073080, rs2143571, rs2228603, rs6487679 and rs738409 with high ALT levels.CONCLUSION: Pooled genetic analysis revealed an association of SNPs in PNPLA3, PARVB, SAMM50 and PZP genes with NAFLD. SNPs in NCAN and PNPLA3gene were associated with higher levels of ALT,whereas variant SNPs in APOC3, PNPLA3, EFCAB4 B and COL13A1 were associated with high triglyceride levels. | Vishnubhotla Venkata Ravi Kanth Mitnala Sasikala Padaki Nagaraja Rao Urmila Steffie Avanthi Kalashikam Rajender Rao Duvvuru Nageshwar Reddy | 2014 | World Journal of Hepatology2014，6，6： | 6 |
| 3 | Clinical-radiological-pathological correlation of cavernous sinus hemangioma: Incremental value of diffusion-weighted imaging显示文摘AIM To elucidate the clinical, magnetic resonance imaging(MRI), pathological features of these lesions and asses the incremental value of diffusion-weighted imaging(DWI) in diagnosing them.METHODS Fifteen consecutive patients(11 females and 4 males; mean age 40.93 years; age range 13-63 years) with cavernous sinus hemangiomas(CSH) who underwent examination between November 2008 and May 2016 were included for the analysis. MRI, clinical and surgical findings of each patient was retrospectively reviewed. DWI were also analysed and mean-apparent diffusion coefficient(ADC) value was calculated. Eleven patients underwent surgical removal of the lesion and 2 patients had biopsy only. Diagnosis of CSH was confirmed histologically in 13 patients.RESULTS Eleven patients(73%) presented with headaches and 10(66%) had cranial nerve involvement. Extra cavernous sinus extension was noted in 14(94%). Surgery was performed in 13(87%) and post-operative radiation was given to 4(28%) patients. Thirteen patients remained asymptomatic on follow up. Three conspicuous imaging features were highly suggestive of the diagnosis: Lack of diffusion restriction(100%), homogeneous hyperintensity on T2 weighted image sequences(93.3%) and intense post-contrast enhancement(100%). The mean ADC was 1.82 × 10-3 ± 0.2186 cm2/s.CONCLUSION T1-weighted hypointensity with homogeneous hyperintensity on T2-weighted sequences, intense enhancement and absence of hemosiderin within the lesion on GRE sequence favour the diagnosis. Facilitated diffusion on DWI differentiates CSH from other solid cavernous sinus lesions and significantly improves the diagnostic accuracy, a critical factor for planning surgery. | Abhishek Mahajan Vedula Rajni Kanth Rao Gudipati Anantaram Ashwin M Polnaya Sandeep Desai Paresh Desai Rammohan Vadapalli Manas Panigrahi | 2017 | World Journal of Radiology2017，9，8： | 4 |
| 4 | Antimicrobial Activity of Ulva reticulata and Its Endophytes显示文摘Seaweeds are known to exhibit various antimicrobial properties,since it harbours an enormous range of indigenous bioactive compounds.The emergence of drug resistant strains has directed to the identification of prospective metabolites from seaweed and its endophytes,thereby exploiting the properties in resisting bacterial diseases.The current study was aimed to assess the antimicrobial activity of extracts obtained from Ulva reticulate,for which metabolites of Ulva reticulata and its endophytes were extracted and assessed against human pathogens like Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,Salmonella typhi,and Bacillus subtilis.It was observed that the hexane extract of isolate VITDSJ2 was effective against all the tested pathogens but a significant inhibition was observed for Staphylococcus aureus and Escherichia coli.Further,Gas chromatography coupled with Mass spectroscopy(GC-MS) revealed the existence of phenol,3,5-bis(1,1-dimethylethyl) in the crude hexane extract which is well-known to possess antibacterial activity.The effective isolate VITDSJ2 was identified to be the closest neighbour of Pseudomonas stutzeri by phenotypic and genotypic methods.The crude extracts of the seaweed Ulva reticulata was also screened for antibacterial activity and the hexane extract was effective in showing inhibition against all the tested pathogens.The compound in the crude extract of Ulva reticulata was identified as hentriacontane using GC-MS.The extracts obtained from dichloromethane did not show significant activity in comparison with the hexane extracts.Hence the metabolites of Ulva reticulata and the bacterial secondary metabolites of the endophytes could be used in the treatment of bacterial infections. | Dhanya K.I. Swati V.I. Vanka Kanth Swaroop Osborne W.J. | 2016 | Journal of Ocean University of China2016，15，2： | 3 |
| 5 | Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management显示文摘Genetics plays an important role in determining the susceptibility of an individual to develop a disease. Complex, multi factorial diseases of modern day(diabetes, cardiovascular disease, hypertension and obesity) are a result of disparity between the type of food consumed and genes, suggesting that food which does not match the host genes is probably one of the major reasons for developing life style diseases. Non-alcoholic fatty liver is becoming a global epidemic leading to substantial morbidity. While various genotyping approaches such as whole exome sequencing using next generation sequencers and genome wide association studies have identified susceptibility loci for non-alcoholic fatty liver disease(NAFLD) including variants in patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 genes apart from others; nutrient based studies emphasized on a combination of vitamin D, E and omega-3 fatty acids to manage fatty liver disease. However majority of the studies were conducted independent of each other and very few studies explored the interactions between the genetic susceptibility and nutrient interactions. Identifying such interactions will aid in optimizing the nutrition tailor made to an individual's genetic makeup, thereby aiding in delaying the onset of the disease and its progression. The present topic focuses on studies that identified the genetic susceptibility for NAFLD, nutritional recommendations, and their interactions for better management of NAFLD. | Vishnubhotla Venkata Ravi Kanth Mitnala Sasikala Mithun Sharma Padaki Nagaraja Rao Duvvuru Nageshwar Reddy | 2016 | World Journal of Hepatology2016，8，20： | 3 |
| 6 | Evaluation of anti–inflammatory and analgesic potential of methanol extract of Tectona grandis flowers显示文摘 | S Ramachandran B Rajini kanth A Rajasekaran KT Manisenthil Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，，2： | 2 |
| 7 | 显示文摘 | Krishnaveni T Rajini Kanth B Rama V S | 2006 | Journal of Alloys and Compounds2006，414，12： | 1 |
| 8 | A new catalytic enantioselective reducing reagent system from (-)-a,a-diphenylpyrrolidinemethanol and 9-borabicyc10nonane, especially effective for hindered and substituted aralkylketones 显示文摘 | Kanth JVB Brown HC | 2002 | Tetrahedron2002，58，： | 1 |
| 9 | Finite element analysis of fir-tree region in turbine dises显示文摘 | Meguid S A Kanth P S Czekanski A | 2000 | Finite Elements in Analysis and Design2000，35，4： | 1 |
| 10 | FiniteElement Analysis of Fr-Tree Region in Turbine Discs显示文摘 | MEGUID SA KANTH PS CZEKANSKI A | 2000 | Finite Elem And Design2000，5，4： | 1 |
| 11 | Genetic interactions between MTHFR(C677T),methionine synthase(A2756G,C2758G)variants with vitamin B12 and folic acid determine susceptibility to premature coronary arterydisease in Indian population显示文摘 | Kanth VV Golla JP Sastry BK | 2011 | J Cardiovasc Dis Res2011，2，3： | 1 |
| 12 | Temperature induced structural, electrical and optical changes in solution processed perovskite material: Application in photovoltaics显示文摘 | Brijesh Tripathi Parth Bhatt P. Chandra Kanth Pankaj Yadav Bhakti Desai Manoj Kumar Pandey Manoj Kumar | 2014 | Solar Energy Materials and Solar Cells2014，，： | 1 |
| 13 | Optical properties of Nd 3+ doped bismuth zinc borate glasses显示文摘 | B. Shanmugavelu V. Venkatramu V.V. Ravi Kanth Kumar | 2014 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2014，，： | 1 |
| 14 | Finite element analysis of fir-tree region in turbine discs显示文摘 | Meguid S A Kanth P S Czekanski A | 2000 | Finite Elements in Analysis and Design2000，35，4： | 1 |
| 15 | Convenient methods for the reduction of amide,nitriles,carboxylic esters,acids and hydroboration of alkenes using NaBH4/I2 system显示文摘 | Bahanu Prasad A S Bhaskar Kanth J V Periasamy M | 1992 | Tetrahedron1992，48，22： | 1 |
| 16 | Mariappan Periasamy, Convenient methods for the reduction of amides, nitriles,carboxylic esters, acids and hydrobiration of alkenes using NaBH4/I2 system显示文摘 | Bhanu Prasad A S Bhaskar Kanth J V | 1992 | Tetrahedron1992，48，22： | 1 |
| 17 | Convenient methods for the reduction of amides, nitriles, carboxylic esters, acids and hydroboration of alkenes using NaBHJ]z system显示文摘 | Prasad A S B Kanth J V B Periasamy M | 1992 | Tetrahed- ron1992，48，22： | 1 |
| 18 | A boy with acute urinary retention: a Mullerian duct remnant (2006: 3b) 显示文摘 | Verma SK Shetty BS Kanth L | 2006 | Eur Radiol2006，16，6： | 1 |
| 19 | Novel methylcellulose-grafted-acrylamide/gelatin microspheres for controlled release of nifedipine 显示文摘 | Babu V R Kanth V R Mukund J M | 2010 | Journal of Ap- plied Polymer Science2010，115，6： | 1 |
| 20 | Convenient methods for the reduction of amides, nitriles, carboxylic esters, acids and hydroboration of alkenes using NaBH4/12 system显示文摘 | Prasad A S Kanth J V Periasamy M | 1992 | Tetrahedron1992，48，22： | 1 |
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