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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury显示文摘Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure,a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury.Inflammasomes are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines,such as interleukin-1β and interleukin-18.These cytokines play a pivotal role in facilitating innate immune responses and inflammation.Among various inflammasome complexes,the NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is the best characterized,a crucial role for NLRP3 has been demonstrated in various brain diseases,including traumatic brain injury.Several recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain injury.Even more important,blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain injury.In this review,we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 inflammasome.Moreover,we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI,and current advances and challenges in potential NLRP3-targeted therapies.A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes. | Saifudeen Ismael Heba A.Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat | 2021 | Neural Regeneration Research2021，16，1： | 5 |
| 3 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver显示文摘Dear Editor,The sodium taurocholate(TC)co-transporting polypeptide NTCP(SLC10A1)is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma into the cytoplasm of liver cells.NTCP was originally cloned from rat and demonstrated to be localized in the basolateral membrane.1 Its activity is a key component of bile acid homeostasis and enterohepatic circulation of bile salts(Fig.1a),a process that includes at least three additional transporter proteins,namely BSEP,ASBT and OSTα/β.2,3 In addition to its role in mediating bile salt uptake,NTCP also serves as the receptor of the human hepatitis B and D viruses.4 The mechanism by which NTCP recognizes and transports bile salts is not understood,in part because no structural insight into the interaction of NTCP with its substrates is available.While recent studies reported structures of NTCP bound to inhibitory nanobodies5 or Fab fragments,6,7 no substrate-binding pockets were identified. | Hongtao Liu Rossitza N.Irobalieva Rose Bang-Sørensen Kamil Nosol Somnath Mukherjee Parth Agrawal Bruno Stieger Anthony A.Kossiakoff Kaspar P.Locher | 2022 | Cell Research2022，32，8： | 2 |
| 4 | River Rafting in Mountainous Regions of Uttarakhand:Impacts,Suggested Mitigation Measures and Sustainability显示文摘Uttarakhand state in India is well known for its mountainous ecosystems,traditional communities and a variety of ecotourism destinations.Among various tourism activities,River Rafting along the banks of the Ganges River has increased tremendously for two decades,and has had unprecedented impacts on the traditional communities and the bio-diversity.Therefore,it is meaningful to do a comprehensive study on the various impacts associated with river rafting so as to suggest the pathways to achieve the environmental sustainability in this region.In this study,we collected primary data from randomly selected population units across all stake holders such as local people(n = 100),and camp personnel(n = 22),through a pre-tested questionnaire survey between August 2009 and May 2010.The questionnaire contains issues on culture,social,economic,institutional and associated perceived impacts on pollution and biodiversity including views for sustainability.Secondary information was also collected from various sources and government records to supplement and strengthen the analysis.The impacts were analyzed qualitatively through a ranking mechanism to facilitate the decision making process.The perception of the interviewee about the various possible impacts of rafting was discussed with mitigating mechanism.The ranking analysis as percollected data reveals that economy and education of local community was improved significantly;however aquatic and terrestrial fauna,social cohesion and pollution(water,air,land) were significantly deteriorated.The results show that the existing practices are not sufficient to address the adverse impacts.Improvement in practices is necessary,mainly in the policy regime.Based on the analysis,some measures are recommended on how to protect community interest and environment with the development of river rafting as an ecotourism opportunity. | Parth Sarathi MAHAPATRA Rajiv PANDEY Sonali PRADHAN | 2012 | Journal of Mountain Science2012，9，4： | 2 |
| 5 | XML-based mobile agents显示文摘 | ROBERT S THARAM D PARTH P YURI V | 2005 | IEEE Computer Society Proceedings of the International Conference on Information Technology:Coding and Computing (ITCC''05)2005，11，： | 1 |
| 6 | A search-free near-field source localization method with exact signal model显示文摘Most of the near-field source localization methods are developed with the approximated signal model,because the phases of the received near-field signal are highly non-linear.Nevertheless,the approximated signal model based methods suffer from model mismatch and performance degradation while the exact signal model based estimation methods usually involve parameter searching or multiple decomposition procedures.In this paper,a search-free near-field source localization method is proposed with the exact signal model.Firstly,the approximative estimates of the direction of arrival(DOA)and range are obtained by using the approximated signal model based method through parameter separation and polynomial rooting operations.Then,the approximative estimates are corrected with the exact signal model according to the exact expressions of phase difference in near-field observations.The proposed method avoids spectral searching and parameter pairing and has enhanced estimation performance.Numerical simulations are provided to demonstrate the effectiveness of the proposed method. | PAN Jingjing SINGH Parth Raj MEN Shaoyang | 2021 | Journal of Systems Engineering and Electronics2021，32，4： | 1 |
| 7 | Temperature induced structural, electrical and optical changes in solution processed perovskite material: Application in photovoltaics显示文摘 | Brijesh Tripathi Parth Bhatt P. Chandra Kanth Pankaj Yadav Bhakti Desai Manoj Kumar Pandey Manoj Kumar | 2014 | Solar Energy Materials and Solar Cells2014，，： | 1 |
| 8 | Matenaal- child oral health behaviors and caries experience in the child 显示文摘 | Parth G Yoon RK Chussid S | 2009 | J Clin Pediatr Dent2009，34，2： | 1 |
| 9 | The arrestin domain-containing3 protein regulates body mass and energy expenditure显示文摘 | Parth P Valur E Eric E S | 2011 | Cell Metabolism2011，14，： | 1 |
| 10 | Calculation of the BOa triangle to BO4 tetrahedron ratio in borates显示文摘 | Parthe E | 2002 | Zeitschrift ftir Kristallographie2002，217，： | 1 |
| 11 | Thioredoxin-independent regulation of metabolism by theα-arrestin proteins显示文摘 | Parth P William A C Kiersten C | 2009 | Journal of Biological Chemistry2009，284，24： | 1 |
| 12 | New examples of crystallized and amorphous borates where the ratio of BO3 triangle to BO4 tetrahedron can be caulat- ed from the chemical formula显示文摘 | Parthe E | 2004 | Journal of Alloys and Com- pounds2004，367，12： | 1 |
| 13 | Structure of YA1Ge and isotypie rare-earth-aluminum germanides 显示文摘 | ZHAO Jing-tai PARTHE E | 1990 | Aeta Crystallographiea C1990，46，： | 1 |
| 14 | Fate of the teratogenic andcarcinogenic ochratoxin A in human perfused placenta显示文摘 | Woo CS ’ PartH Myllynen P | 2012 | ToxicolLett2012，208，1： | 1 |
| 15 | Trigonal B2O3 with higher space-group symmetry: Results of a reevaluation显示文摘 | EFFENBERGER H LENGAUER C L PARTHéE | 2001 | Monatshefte für Chemie2001，132，12： | 1 |
| 16 | Pyrolysis of an alkyltin/polymer mixture to form a tin/carbon composite for use as an anode in lithium-ion batteries显示文摘 | Parth Patel Ⅱ-Seok Kim | 2004 | J Power Sources2004，135，： | 1 |
| 17 | Hydroxyethl starch deposits in human skin-a model for pruritus显示文摘 | Jurecka W Szepfalusi Z Parth E | 1993 | Arch Dermatol Res1993，258，： | 1 |
| 18 | Association of Complications With Blood Transfusions in Pediatric Cardiac Surgery Patients显示文摘 | Amit Iyengar Christopher N. Scipione Parth Sheth Richard G. Ohye Lori Riegger Edward L. Bove Eric J. Devaney Jennifer C. Hirsch-Romano | 2013 | The Annals of Thoracic Surgery2013，，： | 1 |
| 19 | Mechanical Control of Tissue Morphogenesis显示文摘 | Parth Patwari Richard T. Lee | 2008 | Circulation Research2008，，3： | 1 |
| 20 | Laplacian Eigenmaps for Di- mensionality Reduction and Data Representation 显示文摘 | Mikhail B Parth N | 2003 | Neural Computation2003，15，6： | 1 |
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